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Microfluidics-based Single Cell Analytical Platforms for Characterization of Cancer

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Nanomedicine

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Individual cancer cells in a tumor are very diverse both genetically and functionally. Moreover, in many cancers, whether a tumor flourishes or dies after a given treatment depends on a small fraction of cells in the tumor, for instance, the cancer stem cells, rather than the bulk population. Traditionally, scientists only obtain averaged information from the entire population of cells in a bulk tumor, but it is critical to develop an effective and user-friendly platform capable of interrogating single cells in order to understand and treat the disease better. This chapter reviews recent progress of microfluidics-based tools for single cell analysis that are relevant for cancer characterization, as well as how nanotechnology may advance the analysis with improved signal responses. We hope that this general introduction may catalyze the adoption of these advanced single-cell analysis approaches for cancer studies.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark

    Emil Laust Kristoffersen, Morten Leth Jepsen, Birgitta R. Knudsen & Yi-Ping Ho

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  1. Emil Laust Kristoffersen
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  2. Morten Leth Jepsen
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  3. Birgitta R. Knudsen
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  4. Yi-Ping Ho
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Correspondence to Yi-Ping Ho .

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Editors and Affiliations

  1. Department of Molecular Biology and Gen, Interdisciplinary Nanoscience Center (i, Aarhus, Denmark

    Kenneth A. Howard

  2. Department of Biomedicine, Biophysical I, Aarhus University, Aarhus, Denmark

    Thomas Vorup-Jensen

  3. Britannia Bldg, 2nd Fl, Rm 226, Tel-Aviv Univ, Dept Cell Research, Tel-Aviv, Israel

    Dan Peer

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Kristoffersen, E.L., Jepsen, M.L., Knudsen, B.R., Ho, YP. (2016). Microfluidics-based Single Cell Analytical Platforms for Characterization of Cancer. In: Howard, K., Vorup-Jensen, T., Peer, D. (eds) Nanomedicine. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3634-2_5

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