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The Application of Nanotechnology for Implant Drug Release

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Nanomedicine

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

The use of medical implants is a cornerstone of modern medicine. All implants face, however, a number of challenges including infection and inflammation which cause many of them to fail. In addition, tissue engineering implants must also direct stem cell differentiation and tissue regeneration in order to work properly. These problems may be overcome using drugs that are delivered directly from the implant. For this to work the drugs have to be protected until they have performed their function, their release must be timed with when they are needed, they may have to affect specific regions of an implant only and some drugs must be delivered to specific sub-cellular locations in certain cells types. This chapter explores how various forms of nanotechnology may be employed to reach these goals and reviews many of the studies that have used nanotechnology for different implant mediated drug release applications.

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Authors and Affiliations

  1. The Maersk Mc-Kinney Moller Institute and Department of Chemical Engineering, Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Allé 1, 5230, Odense M, Denmark

    Morten Østergaard Andersen

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  1. Morten Østergaard Andersen
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  1. Department of Molecular Biology and Gen, Interdisciplinary Nanoscience Center (i, Aarhus, Denmark

    Kenneth A. Howard

  2. Department of Biomedicine, Biophysical I, Aarhus University, Aarhus, Denmark

    Thomas Vorup-Jensen

  3. Britannia Bldg, 2nd Fl, Rm 226, Tel-Aviv Univ, Dept Cell Research, Tel-Aviv, Israel

    Dan Peer

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Andersen, M.Ø. (2016). The Application of Nanotechnology for Implant Drug Release. In: Howard, K., Vorup-Jensen, T., Peer, D. (eds) Nanomedicine. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3634-2_13

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