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The Use of Silk in Nanomedicine Applications

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Nanomedicine

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Biopolymers made up of silk proteins have been used in numerous drug delivery applications and represent an excellent source of natural biomaterials. In particular silk fibroin has proved valuable as a building block for nanomedicines and drug delivery implants, owing to its favorable biocompatibility, degradation, stabilization and controllability. In this chapter we will discuss the various sources of silk biomaterial and how this naturally occurring biopolymer has been utilized in the development of nanomedicines and implantable drug delivery systems, demonstrating how silk is a unique biological template which has opened up many possibilities for the generation of functional biomaterials and drug delivery systems in a green and cost-effective manner.

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Acknowledgements

This work was supported by a Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C, from the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). This work was also supported by NIH grants CA151884 and the David Koch-Prostate Cancer Foundation Award in Nanotherapeutics.

Conflict of interest statement Dr. Farokhzad declares financial interests in BIND Therapeutics, Selecta Biosciences, Tarveda Therapeutics and Playcon Therapeutics, four biotechnology companies developing nanoparticle technologies for medical applications. All other authors declare no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Raymond Chiasson, Moaraj Hasan, Qusai Al Nazer, Omid C. Farokhzad & Nazila Kamaly

  2. Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, 2800 Kgs., Lyngby, Denmark

    Nazila Kamaly

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  1. Raymond Chiasson
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  2. Moaraj Hasan
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  3. Qusai Al Nazer
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  4. Omid C. Farokhzad
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Correspondence to Omid C. Farokhzad .

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  1. Department of Molecular Biology and Gen, Interdisciplinary Nanoscience Center (i, Aarhus, Denmark

    Kenneth A. Howard

  2. Department of Biomedicine, Biophysical I, Aarhus University, Aarhus, Denmark

    Thomas Vorup-Jensen

  3. Britannia Bldg, 2nd Fl, Rm 226, Tel-Aviv Univ, Dept Cell Research, Tel-Aviv, Israel

    Dan Peer

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Chiasson, R., Hasan, M., Al Nazer, Q., Farokhzad, O.C., Kamaly, N. (2016). The Use of Silk in Nanomedicine Applications. In: Howard, K., Vorup-Jensen, T., Peer, D. (eds) Nanomedicine. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3634-2_11

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