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Remodeling of Mitochondria in Apoptosis

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Mitochondria and Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

Abstract

This chapter addresses the cellular remodeling that occurs in apoptosis with a focus on the structural changes to mitochondria, which sit in the center of the apoptotic pathway. Accumulating evidence points to the intricate timing and complex interplay of six events involved with the complete release of cytochrome c, called the execution phase or “point of no return” of apoptosis: (1) the activation of specific signaling pathways converging on mitochondria, (2) the arrival and interplay of DRP1, tBID, BAX and BAK at the mitochondrial outer membrane, (3) ER-actin filament-mitochondria association leading to mitochondrial fission remodeling, (4) the opening of crista junctions triggered by disassembly of OPA1 oligomers, (5) the dissolution of the cardiolipin–cytochrome c association leading to passage of cytochrome c from the intracristal space to the intermembrane space, and (6) the formation of mitochondrial outer membrane pores for the relatively rapid and complete release of cytochrome c from the intermembrane space to the cytosol. Each of these six events is a checkpoint for strategies that would enhance or impede apoptotic progression.

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Authors and Affiliations

  1. Center for Research in Biological Systems, National Center for Microscopy and Imaging Research, University of California at San Diego, La Jolla, CA, 92093-0608, USA

    Guy A. Perkins & Mark H. Ellisman

  2. Department of Neurosciences, University of California at San Diego, La Jolla, CA, 92093-0608, USA

    Mark H. Ellisman

  3. Department of Bioengineering, University of California at San Diego, La Jolla, CA, 92093-0608, USA

    Mark H. Ellisman

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  1. Guy A. Perkins
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  2. Mark H. Ellisman
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Correspondence to Guy A. Perkins .

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  1. Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    David M. Hockenbery

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Perkins, G.A., Ellisman, M.H. (2016). Remodeling of Mitochondria in Apoptosis. In: Hockenbery, D. (eds) Mitochondria and Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3612-0_5

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