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Metabolic Acidosis pp 77–86Cite as

The Physiology of the Metabolic Acidosis of Chronic Kidney Disease (CKD)

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Abstract

The kidney is the main organ responsible for excreting the “fixed” acid that continuously challenges acid–base balance. Clinicians diagnose metabolic acidosis in patients with supportive histories and appropriate changes in serum acid–base parameters. Metabolic acidosis is a common complication of chronic kidney disease (CKD) and typically is observed in patients with severe rather than modest reductions in kidney function. Understanding the physiology of the metabolic acidosis of CKD informs treatment strategies and provides insights into mechanisms for some CKD complications. The high-acid-producing diets typical of industrialized societies appear to increase the risk for metabolic acidosis at a given level of kidney function, suggesting the potential for dietary acid reduction as a treatment strategy.

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Authors and Affiliations

  1. Baylor Scott and White Health, Texas A&M Health Sciences Center College of Medicine, 2401 South 31st Street, Temple, TX, 76508, USA

    Nimrit Goraya M.D.

  2. Baylor Scott and White Health, Department of Internal Medicine, Texas A&M Health Sciences Center College of Medicine, 2401 South 31st Street, Temple, TX, 76508, USA

    Donald E. Wesson M.D., M.B.A.

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  1. Nimrit Goraya M.D.
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  2. Donald E. Wesson M.D., M.B.A.
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Correspondence to Donald E. Wesson M.D., M.B.A. .

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Editors and Affiliations

  1. Baylor Scott & WhiteHealth Dept Int Med., Texas A&M Health Sci. Cent. Collg of Med, Temple, Texas, USA

    Donald E. Wesson

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Goraya, N., E. Wesson, D. (2016). The Physiology of the Metabolic Acidosis of Chronic Kidney Disease (CKD). In: E. Wesson, D. (eds) Metabolic Acidosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3463-8_8

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  • DOI: https://doi.org/10.1007/978-1-4939-3463-8_8

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