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Edge-to-Edge Repair (MitraClip), Degenerative

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Catheter Based Valve and Aortic Surgery

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Abstract

The MitraClip device was conceived of as a percutaneous method to mimic the surgical edge-to-edge or double-orifice mitral repair. A surgical double-orifice repair was initially utilized in patients with degenerative mitral regurgitation (MR), involving prolapse of the middle scallops of the line of mitral coaptation. The EVEREST II pivotal trial compared MitraClip with surgical mitral repair or replacement in a predominantly degenerative MR population and demonstrated that surgical repair is more effective at reducing MR than MitraClip, but that the MitraClip device achieved similar levels of clinical efficacy and left ventricular remodeling and is, as was expected, safer than surgical approaches. Clinical uptake of MitraClip in commercial international practice has been used mostly among high-risk patients with functional MR with similar efficacy and safety, and over 25,000 patients have been treated. The evidence base for use of MitraClip now includes the EVEREST trials and prospective registry data for over 5000 patients. This review summarizes this database.

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Authors and Affiliations

  1. Cardiac Catheterization Laboratory, Cardiology Division, Evanston Hospital, NorthShore University HealthSystem, Walgreen Building 3rd Floor, 2650 Ridge Avenue, Evanston, IL, 60201, USA

    Mohammad Sarraf MD & Ted Feldman MD, MSCAI, FACC, FESC

Authors
  1. Mohammad Sarraf MD
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  2. Ted Feldman MD, MSCAI, FACC, FESC
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Corresponding author

Correspondence to Ted Feldman MD, MSCAI, FACC, FESC .

Editor information

Editors and Affiliations

  1. Department of Surgery, Advanced Cardiac Valve Center, Universit, Charlottesville, Virginia, USA

    Gorav Ailawadi

  2. Department of Surgery, University of Virginia, Charlottesville, Virginia, USA

    Irving L. Kron

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Sarraf, M., Feldman, T. (2016). Edge-to-Edge Repair (MitraClip), Degenerative. In: Ailawadi, G., Kron, I. (eds) Catheter Based Valve and Aortic Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3432-4_13

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  • DOI: https://doi.org/10.1007/978-1-4939-3432-4_13

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-3430-0

  • Online ISBN: 978-1-4939-3432-4

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