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Membrane Protein Folding and Structure

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Ion Channels and Transporters of Epithelia in Health and Disease

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Seminal structural and biochemical studies demonstrated that proteins are organized by specific structural elements and that the information necessary to form these ordered structures is encoded in the polypeptide chain. Questions related to the mechanisms of protein folding for both soluble and transmembrane proteins remain a large field of research utilizing a combination of biochemical, biophysical, genetic, and large-scale computational approaches. Understanding these processes has broad implications for the functional identification of unknown and putative proteins found in sequenced genomes, for the characterization of disease-causing mutations identified in genetic studies, and for rational design and protein engineering efforts to introduce novel biological function. This chapter will outline the basic principles related to transmembrane protein folding and provide an overview of transmembrane protein structure determination.

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  1. Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Dr., 519 Bridgeside Point II, Pittsburgh, PA, 15219, USA

    Liang Zhang & Patrick H. Thibodeau

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  1. Department of Physiology, University of Otago , Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Daniel C Devor

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Zhang, L., Thibodeau, P.H. (2016). Membrane Protein Folding and Structure. In: Hamilton, K., Devor, D. (eds) Ion Channels and Transporters of Epithelia in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3366-2_8

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