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Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells

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Circulating Tumor Cells

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

Very little is known about the molecular biology of CTCs. The paucity of information can be largely attributed to the technical hurdles in isolating these extremely rare cells. Despite these challenges, there is a pressing need to elucidate the molecular characteristics of these tumor cells. In this chapter, we highlight recent studies on genome-wide gene copy number analysis of CTCs and comparisons with primary tumors. These initial studies serve as groundwork for future efforts in discovery and development of novel CTC-based genomic biomarkers. Further molecular profiling of CTCs may provide novel insights into mechanisms of disease progression and tumor evolution, and open new avenues for personalized treatment.

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Author information

Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA

    Mark Jesus M. Magbanua M.S. Ph.D.

  2. Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA

    Mark Jesus M. Magbanua M.S. Ph.D.

  3. Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, 4th Floor, San Francisco, CA, 94115-3010, USA

    John W. Park M.D.

Authors
  1. Mark Jesus M. Magbanua M.S. Ph.D.
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  2. John W. Park M.D.
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Corresponding author

Correspondence to John W. Park M.D. .

Editor information

Editors and Affiliations

  1. Jackson Memorial Hospital, University of Miami, Miami, Florida, USA

    Richard J. Cote

  2. University of Miami, Miami, Florida, USA

    Ram H. Datar

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Magbanua, M.J.M., Park, J.W. (2016). Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells. In: Cote, R., Datar, R. (eds) Circulating Tumor Cells. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3363-1_10

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  • DOI: https://doi.org/10.1007/978-1-4939-3363-1_10

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  • Print ISBN: 978-1-4939-3361-7

  • Online ISBN: 978-1-4939-3363-1

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