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Radionuclide Imaging of Thyroid Nodules

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Thyroid Cancer

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Abstract

Thyroid scintigraphy has been used for many years to evaluate thyroid nodules. The clinical value of thyroid scintigraphy has been established based on the knowledge that (1) functioning nodules have not only increased radioiodine uptake relative to normal functioning thyroid tissue but also have a low probability of malignancy and (2) thyroid cancers have no or very low radioiodine accumulation relative to normal thyroid tissue. This chapter presents an overview of thyroid scintigraphy in the evaluation of thyroid nodules (see Table 24.1).

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References

  1. Society of Nuclear Medicine Procedure Guideline for Thyroid Scintigraphy, version 2.0, approved February 7, 1999. Procedure Guidelines Manual, Society of Nuclear Medicine, 2003:29–32.

    Google Scholar 

  2. McKitrick WL, Park HM, Kosegi JE. Parallax error in pinhole thyroid scintigraphy: a critical consideration in the evaluation of substernal goiters. J Nucl Med. 1985;26:418–20.

    CAS  PubMed  Google Scholar 

  3. Borner W, Lautsch M, et al. Die diagnostiche bedeutung des “kalten Knotens” im schilddrusenszintigramm. Med Welt. 1965;17:892–7.

    Google Scholar 

  4. Ashcraft MW, Van Herle AJ. Management of thyroid nodules. II. Scanning techniques, thyroid suppressive therapy, and fine needle aspiration. Head Neck Surg. 1981;3:296–322.

    Google Scholar 

  5. Sandler MP, Coleman RE, Patton JA, et al. Diagnostic nuclear medicine. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2003.

    Google Scholar 

  6. Mulnar GD, Childs DS, Wollner LB. Histologic evidence of malignancy in a thyroid gland bearing a “hot” nodule. J Clin Endocrinol Metab. 1958;18:1132–4.

    Article  Google Scholar 

  7. Becker FO, Economou PH, Schwartz TB. The occurrence of carcinoma in “hot” thyroid nodules: report of two cases. Ann Intern Med. 1963;58:877–82.

    Article  CAS  PubMed  Google Scholar 

  8. Dische S. The radioisotope scan applied to the detection of carcinoma in the thyroid swellings. Cancer. 1963;17:473–9.

    Article  Google Scholar 

  9. McLaughlin RP, Scholz DA, McConahey WM, et al. Metastatic thyroid carcinoma with hyperthyroidism: two cases with functioning metastatic follicular thyroid carcinoma. Mayo Clin Proc. 1970;45:328–35.

    CAS  PubMed  Google Scholar 

  10. Meier DA, Hamburger JI. An autonomously functioning thyroid nodule, cancer, and prior radiation. Arch Surg. 1971;12:759–61.

    Article  Google Scholar 

  11. Ghose MK, Genuth SM, Abellera RM, et al. Functioning primary thyroid carcinoma and metastases producing hyperthyroidism. J Clin Endocrinol Metab. 1971;33:639–46.

    Article  Google Scholar 

  12. Fujimoto Y, Oka A, Nagataki S. Occurrence of papillary carcinoma in hyperfunctioning thyroid nodule report of a case. Endocrinol Japanonica. 1972;19:371–4.

    Article  CAS  Google Scholar 

  13. Hamburger JI. Solitary autonomously functioning thyroid lesions. Am J Med. 1975;58:740–9.

    Article  CAS  PubMed  Google Scholar 

  14. Turner JW, Spencer RP. Thyroid carcinoma presenting as a pertechnetate “hot” nodule, but without I131 uptake; case report. J Nucl Med. 1976;17:22–3.

    CAS  PubMed  Google Scholar 

  15. Livada DP, Kotoulad OB, Bouropoulos V, Sfonouris J, et al. The coexistence of thyroid malignancy with autonomous hot nodules of the thyroid. Clin Nucl Med. 1977;2:350–4.

    Article  Google Scholar 

  16. Raikar UR, Ganatra RD, Raghunath B. Thyroid carcinoma in an autonomously functioning nodule. J Nucl Med. 1977;18:1001–2.

    Google Scholar 

  17. Wolfstein RS. Enigma of the “hyperfunctioning” thyroid carcinoma resolved? J Nucl Med. 1978;19:441–2.

    CAS  PubMed  Google Scholar 

  18. Blitzer A. Thyroid carcinoma in a patient with a coexisting functional adenoma. Otolaryngol Head and Neck Surg. 1979;87:768–74.

    Article  CAS  Google Scholar 

  19. Khan O, Ell PJ, Maclennan KA, Kurtz A, et al. Thyroid carcinoma in an autonomously hyperfunctioning thyroid nodule. Postgrad Med J. 1981;57:172–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Hoving J, Piers DA, Vermey A, et al. Carcinoma in hyperfunctioning thyroid nodule in recurrent hyperthyroidism. Eur J Nucl Med. 1981;6:131–2.

    Article  CAS  PubMed  Google Scholar 

  21. Sandler MP, Fellmeth B, Salhany KE, et al. Thyroid carcinoma masquerading as a solitary benign hyperfunctioning nodule. Clin Nucl Med. 1988;13:410–5.

    Article  CAS  PubMed  Google Scholar 

  22. Rubenfeld S, Wheeler TM. Thyroid cancer presenting as a hot thyroid nodule: report of a case and review of the literature. Thyroidology. 1988;1:63–8.

    PubMed  Google Scholar 

  23. DeRosa G, Testa A, Maurizi M, et al. Thyroid carcinoma mimicking a toxic adenoma. Eur J Nucl Med. 1990;17:179–84.

    Article  CAS  Google Scholar 

  24. Castelli V, Moscogiuri D, Taviani AP, et al. Occurrence of papillary carcinoma in a hyperfunctioning thyroid nodule: report of a case and diagnostic considerations. Thyroidol Clin Exp. 1994;6:69–72.

    CAS  PubMed  Google Scholar 

  25. Das AB, Alam MN, Haq SA, et al. Solitary thyroid nodule: a study of 100 cases. Bangladesh Med Res Clin Bull. 1996;22:12–8.

    CAS  Google Scholar 

  26. Sato Y, Sakurai A, Miyamoto T, Hiramatsu K, et al. Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. Endocr J. 1998;45:61–7.

    Article  CAS  PubMed  Google Scholar 

  27. Cirillo Jr RL, Pozderac RV, Caniano DA, et al. Metastatic pure papillary thyroid carcinoma presenting as a toxic hot nodule. Clin Nucl Med. 1998;23:345–9.

    Article  PubMed  Google Scholar 

  28. Appetecchia M, Ducci M. Hyperfunctioning differentiated thyroid carcinoma. J Endocrinol Invest. 1998;21:189–92.

    Article  CAS  PubMed  Google Scholar 

  29. Valenti TM, Macchia E, Pisa R, et al. Toxic adenoma and papillary thyroid carcinoma in a patient with Graves disease. J Endocrinol Invest. 1999;22:701–4.

    Article  CAS  PubMed  Google Scholar 

  30. Mircescu H, Parma J, Huot C, et al. Hyperfunctioning malignant thyroid nodule in an 11-y.o. J Pediatr. 2000;137:585–7.

    Article  CAS  PubMed  Google Scholar 

  31. Lupi A, Orsolon P, Cerisara D, Migliorati Deantoni G, Dri VA. “Hot” carcinoma of the thyroid. Minerva Endocrinol. 2002;27:53–6.

    CAS  PubMed  Google Scholar 

  32. Logani S, Osei SY, LiVolsi VA, et al. Fine-needle aspiration of follicular variant of papillary carcinoma in a hyperfunctioning thyroid nodule. Diagn Cytopathology. 2001;25:80–1.

    Article  CAS  Google Scholar 

  33. Yaturu S, Fowler MR. Differentiated thyroid carcinoma with functional autonomy. Endocr Pract. 2002;8:36–9.

    Article  PubMed  Google Scholar 

  34. Dell’Erba L, Gerundini P, Caputo M, et al. Association of hyperfunctioning thyroid adenoma with thyroid cancer resenting as “trapping only” nodule at 99mTcO4 – scintigraphy. J Endocr Invest. 2003;26:1124–7.

    Article  PubMed  Google Scholar 

  35. Pucci A, Suppo M, Lucchesi G, et al. Papillary thyroid carcinoma presenting as a solitary soft tissue arm metastasis in an elderly hyperthyroid patient. Case report and review of the literature. Virchows Arch. 2006;448:857–61.

    Article  PubMed  Google Scholar 

  36. Nishida A, Hirano S, Asato R, et al. Multifocal hyper functioning thyroid carcinoma without metastases. Auris Nasus Larynx. 2008;35:432–6.

    Article  PubMed  Google Scholar 

  37. Tfayli HM, Teot LA, Indyk JA, et al. Papillary thyroid carcinoma in an autonomous hyperfunctioning thyroid nodule: case report and review of the literature. Thyroid. 2010;20:1029–32.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Bommireddipalli S, Goel S, Gadiraju R, et al. Follicular variant of papillary thyroid carcinoma presenting as a toxic nodule by I-123 scintigraphy. Clin Nucl Med. 2010;35:770–5.

    Article  PubMed  Google Scholar 

  39. Azevedo MF, Casulari LA. Hyperfunctioning thyroid cancer: a 5 yr follow up. Arq Bras Endocrinol Metab. 2010;54:78–80.

    Article  Google Scholar 

  40. Hernan-Martinez J, Uzcategui M, Corder E, et al. Hyperthyroidism, hyperfunctioning thyroid nodule, and thyroid cancer in a young female: a rare and unusual coexistence. P R Health Sci J. 2010;29:78–82.

    PubMed  Google Scholar 

  41. Schneider MT, Glister O, Hall JP, Acio E, Kulkarni KP, Tran AT, Van Nostrand D. Thyroid cancer in functioning thyroid nodules. Presented at the 2012 ACNM Mid-Winter meeting.

    Google Scholar 

  42. Kusic Z, Becker DV, Saenger EL, et al. Comparison of technetium99m and iodine-123 imaging of thyroid nodules: correlation with pathologic findings. J Nucl Med. 1990;31:393–9.

    CAS  PubMed  Google Scholar 

  43. Ryo UY, Vaidya PV, Schneider AB, et al. Thyroid imaging agents: a comparison of I-123 and Tc-99m pertechnetate. Radiology. 1983;148:819–22.

    Article  CAS  PubMed  Google Scholar 

  44. Erjavec M, Movrin T, Auersperg M, Golough R. Comparative accumulation of 99mTc and 131I in thyroid nodules: case report. J Nucl Med. 1977;18:346–7.

    Google Scholar 

  45. Dos Remedios LV, Weber PM, Jasko IA. Thyroid scintiphotography in 1,000 patients: rational use of 99mTC and 131-I compounds. J Nucl Med. 1971;12:673–7.

    PubMed  Google Scholar 

  46. Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology. Thyroid carcinoma. Follicular Thyroid Carcinoma. V.1.2010.

    Google Scholar 

  47. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.

    Article  PubMed  Google Scholar 

  48. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JWA, Wiersinga W, the European Thyroid Cancer Taskforce. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol. 2006;154:787–803.

    Article  CAS  PubMed  Google Scholar 

  49. Wartofsky L, Van Nostrand D, Bloom G. Thyroid cancer: a guide for patients. Baltimore: Keystone Press; 2004. p. 15–31.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Nuclear Medicine Research, MedStar Research Institute and Washington Hospital Center, Georgetown University School of Medicine, Washington Hospital Center, 110 Irving Street, N.W., Suite GB 60F, Washington, DC, 20010, USA

    Douglas Van Nostrand MD, FACP, FACNM

  2. Cardiovascular/Metabolic, Boehringer Ingelheim, Chicago, IL, USA

    Mark Schneider MD

  3. Division of Nuclear Medicine, Department of Medicine, MedStar Washington Hospital Center, Washington, DC, USA

    Elmo R. Acio MD

Authors
  1. Douglas Van Nostrand MD, FACP, FACNM
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  2. Mark Schneider MD
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  3. Elmo R. Acio MD
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Corresponding author

Correspondence to Douglas Van Nostrand MD, FACP, FACNM .

Editor information

Editors and Affiliations

  1. Department of Medicine, MedStar Washington Hospital Center Georgetown University School of Medicine, Washington, DC, USA

    Leonard Wartofsky

  2. Nuclear Medicine Research MedStar Research Institute and Washington Hospital Center, Georgetown University School of Medicine Washington Hospital Center, Washington, DC, USA

    Douglas Van Nostrand

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Van Nostrand, D., Schneider, M., Acio, E.R. (2016). Radionuclide Imaging of Thyroid Nodules. In: Wartofsky, L., Van Nostrand, D. (eds) Thyroid Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3314-3_24

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  • DOI: https://doi.org/10.1007/978-1-4939-3314-3_24

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