Abstract
Early detection has led to significant gains in cancer-free survival rates for kidney cancer patients, and the preservation of renal function has emerged as an important objective. Diabetes and hypertension are important independent risk factors for the development of renal cell carcinoma, so the corresponding diabetic and/or hypertensive kidney injuries are commonly encountered. With the number of kidney cancer survivors approaching 350,000 in the USA, further gains in the clinical outcomes for kidney cancer can be achieved with additional attention on the harmful impact of nonneoplastic kidney diseases and improved coordination between urologists, nephrologists, and pathologists during the management of these patients.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAbbreviations
- CKD:
-
Chronic kidney disease
- EM:
-
Electron microscopy
- FSGS:
-
Focal segmental glomerulosclerosis
- IF:
-
Immunofluorescence
- NSS:
-
Nephron-sparing surgery
- RCC:
-
Renal cell carcinoma
- RN:
-
Radical nephrectomy
- PN:
-
Partial nephrectomy
- TMA:
-
Thrombotic microangiopathy
References
Patard J-J. Incidental renal tumours. Curr Opin Urol. 2009;19(5):454–8.
Pichler M, Hutterer GC, Chromecki TF, Jesche J, Kampel-Kettner K, Pummer K, et al. Renal cell carcinoma stage migration in a single European centre over 25 years: effects on 5- and 10-year metastasis-free survival. Int Urol Nephrol. 2012;44(4):997–1004.
Lau WKO, Blute ML, Weaver AL, Torres VE, Zincke H. Matched comparison of radical nephrectomy vs nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney. Mayo Clin Proc. 2000;75(12):1236–42.
Tan H-J, Norton EC, Ye Z, Hafez KS, Gore JL, Miller DC. Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. J Am Med Assoc. 2012;307(15):1629–35.
Jewett MAS, Mattar K, Basiuk J, Morash CG, Pautler SE, Siemens DR, et al. Active surveillance of small renal masses: progression patterns of early stage kidney cancer. Eur Urol. 2011;60(1):39–44.
Campbell SC, Novick AC, Belldegrun A, Blute ML, Chow GK, Derweesh IH, et al. Guideline for management of the clinical T1 renal mass. J Urol. 2009;182(4):1271–9.
Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–305.
The National Kidney Foundation: News [Internet]. http://www.kidney.org/news/newsroom/factsheets/FastFacts.cfm. Cited 31 Jan 2014.
Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006;7(9):735–40.
Rifkin DE. Doctors without metaphors. Am J Kidney Dis. 2009;54(5):A35–6.
Denton MD, Magee CC, Ovuworie C, Mauiyyedi S, Pascual M, Colvin RB, et al. Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis. Kidney Int. 2002;61(6):2201–9.
Lowrance WT, Ordoñez J, Udaltsova N, Russo P, Go AS. CKD and the risk of incident cancer. J Am Soc Nephrol. 2014;25(10):2327–34.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;3:1–150.
Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis. 2014;63(5):713–35.
Henriksen KJ, Meehan SM, Chang A. Non-neoplastic renal diseases are often unrecognized in adult tumor nephrectomy specimens: a review of 246 cases. Am J Surg Pathol. 2007;31(11):1703–8.
Salvatore SP, Cha EK, Rosoff JS, Seshan SV. Nonneoplastic renal cortical scarring at tumor nephrectomy predicts decline in kidney function. Arch Pathol Lab Med. 2013;137(4):531–40.
Srigley JR, Amin MB, Delahunt B, Campbell SC, Chang A, Grignon DJ, et al. Protocol for the examination of specimens from patients with invasive carcinoma of renal tubular origin. Arch Pathol Lab Med. 2010;134(4):e25–30.
Algaba F, Delahunt B, Berney DM, Camparo P, Compérat E, Griffiths D, et al. Handling and reporting of nephrectomy specimens for adult renal tumours: a survey by the European Network of Uropathology. J Clin Pathol. 2012;65(2):106–13.
Nasr SH, Galgano SJ, Markowitz GS, Stokes MB, D’Agati VD. Immunofluorescence on pronase-digested paraffin sections: a valuable salvage technique for renal biopsies. Kidney Int. 2006;70(12):2148–51.
Van der Ven K, Nguyen TQ, Goldschmeding R. Immunofluorescence on proteinase XXIV-digested paraffin sections. Kidney Int. 2007;72(7):896.
Nasr SH, Markowitz GS, Valeri AM, Yu Z, Chen L, D’Agati VD. Thin basement membrane nephropathy cannot be diagnosed reliably in deparaffinized, formalin-fixed tissue. Nephrol Dial Transplant. 2007;22(4):1228–32.
Bonsib SM, Pei Y. The non-neoplastic kidney in tumor nephrectomy specimens: what can it show and what is important? Adv Anat Pathol. 2010;17(4):235–50.
Zucchetto A, Dal Maso L, Tavani A, Montella M, Ramazzotti V, Talamini R, et al. History of treated hypertension and diabetes mellitus and risk of renal cell cancer. Ann Oncol. 2007;18(3):596–600.
Bijol V, Mendez GP, Hurwitz S, Rennke HG, Nosé V. Evaluation of the nonneoplastic pathology in tumor nephrectomy specimens: predicting the risk of progressive renal failure. Am J Surg Pathol. 2006;30(5):575–84.
Markowitz GS, Lin J, Valeri AM, Avila C, Nasr SH, D’Agati VD. Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking. Hum Pathol. 2002;33(8):826–35.
Chow WH, Gridley G, Fraumeni JF, Järvholm B. Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med. 2000;343(18):1305–11.
Choi MY, Jee SH, Sull JW, Nam CM. The effect of hypertension on the risk for kidney cancer in Korean men. Kidney Int. 2005;67(2):647–52.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media New York
About this chapter
Cite this chapter
Chang, A., Bijol, V. (2016). Nonneoplastic Kidney Diseases in the Setting of a Renal Mass. In: Hansel, D., Kane, C., Paner, G., Chang, S. (eds) The Kidney. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3286-3_13
Download citation
DOI: https://doi.org/10.1007/978-1-4939-3286-3_13
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-3285-6
Online ISBN: 978-1-4939-3286-3
eBook Packages: MedicineMedicine (R0)