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Regenerative Rehabilitation: Synergizing Regenerative Medicine Therapies with Rehabilitation for Improved Muscle Regeneration in Muscle Pathologies

  • Kristen Stearns-Reider
  • Fabrisia Ambrosio
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

With recent advances in the understanding of the molecular basis for tissue regeneration, regenerative medicine therapies for a host of musculoskeletal disorders are becoming available at an ever increasing pace. One promising area for the application of such therapies is toward the regeneration of skeletal muscle tissue. A host of disorders and pathologies contribute to the loss of skeletal muscle, including muscular dystrophies, acute trauma, tumor resection, and age-related sarcopenia. While some of these disorders have a relatively mild impact on the loss of muscle strength and function, others are so severe that they lead to the need for limb amputation or, in the worst cases, death. Therefore, regenerative medicine strategies are critical for the treatment of many musculoskeletal disorders.

Keywords

Duchenne Muscular Dystrophy Mechanical Stimulation Muscle Regeneration Muscle Satellite Cell PLGA Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Integrative Biology and PhysiologyUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Department of Physical Medicine and RehabilitationUniversity of PittsburghPittsburghUSA
  3. 3.McGowan Institute for Regenerative Medicine, University of PittsburghPittsburghUSA

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