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Regenerative Medicine for Degenerative Muscle Diseases pp 295–307Cite as

miRNAs in Muscle Diseases

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Since their first characterization in 1990, miRNAs, the small RNAs that can inhibit gene expression, have been studied extensively. Important roles of miRNAs have been found in cancer, heart disease, obesity, nervous system, and lately muscle diseases. In this chapter, we will review the roles of miRNAs in muscle repair and special pathology aspect of myopathies and then correlate these roles into potential therapeutic approaches for muscle diseases. We will also analyze the advantages and the caution needed when using miRNAs in targeting muscle dystrophies.

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Authors and Affiliations

  1. Departments of Biochemistry, Biology, Bioengineering, Genome Sciences, Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, 98109, USA

    Diem-Hang Nguyen-Tran & Hannele Ruohola-Baker

  2. Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, 32608, USA

    Diem-Hang Nguyen-Tran

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  1. Diem-Hang Nguyen-Tran
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  2. Hannele Ruohola-Baker
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Correspondence to Hannele Ruohola-Baker .

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Editors and Affiliations

  1. Department of Rehabilitation Medicine, University of Washington Department of Rehabilitation Medicine, WINSTON SALEM, North Carolina, USA

    Martin K. Childers

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Nguyen-Tran, DH., Ruohola-Baker, H. (2016). miRNAs in Muscle Diseases. In: Childers, M. (eds) Regenerative Medicine for Degenerative Muscle Diseases. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3228-3_11

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