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Bile Acids, the Microbiome and Metabolic Disease-Implications for Surgery

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Metabolic Syndrome and Diabetes

Abstract

Perhaps one of the most exciting frontiers of medicine is the exploration of the human gut flora, or the microbiome. While it remains with significant possibility as a target for future therapeutics, defining a healthy microbiome and pathologic variant remains enigmatic. Remarkable changes in the microbiome are observed after bariatric surgery which may be a key in understanding and linking microbial shifts with functionality and metabolic phenotype. Herein, we review our current understanding of the gut microbiome as it relates to obesity and Type 2 Diabetes Mellitus, and changes that follow bariatric surgery.

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Authors and Affiliations

  1. Department of Surgery, University of Minnesota, 420 Delaware St. SE, MMC 195, Minneapolis, MN, 55455, USA

    Cyrus Jahansouz M.D.

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  1. Cyrus Jahansouz M.D.
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Correspondence to Cyrus Jahansouz M.D. .

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  1. Department of Surgery, NYU School of Medicine, New York, New York, USA

    Marina Kurian

  2. Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA

    Bruce M. Wolfe

  3. Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA

    Sayeed Ikramuddin

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Jahansouz, C. (2016). Bile Acids, the Microbiome and Metabolic Disease-Implications for Surgery. In: Kurian, M., Wolfe, B., Ikramuddin, S. (eds) Metabolic Syndrome and Diabetes. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3220-7_6

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