Abstract
The survival of our ancestors was highly dependent on hunting, gathering”: and fighting, behaviors that demanded intense physical activity. A sedentary lifestyle in that environment would certainly result in the elimination of the individuals. This situation imposed a selective pressure directed to adaptations of human physiology to a high capacity of physical activity, resulting in the development of a very efficient locomotor system, in which the skeletal muscles correspond to about 40 % of the body mass and account for a great proportion of the average energy consumption of the organism. The present-day sedentarism is dissonant with the human genetic background selected to favor a physically active lifestyle and probably consists in one of the main causes of the increasing incidence of modern chronic diseases, such as hypertension, obesity, and insulin resistance.
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Selected Bibliography
Atkinson DE (1968) The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 7:4030–4034
Harris DA (1998) Getting to grips with contraction: the interplay of structure and biochemistry. Trends Biochem Sci 23:84–87
Huxley HE (2005) Memories of early work on muscle contraction and regulation in the 1950’s and 1960’s. Biochem Biophys Res Commun 369:34–42
Kiens B (2006) Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 86:205–243
Oakhill JS, Scott JW, Kemp BE (2012) AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab 23:125–132
Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457–465
Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL (2001) Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins 43:175–185
Rose AJ, Richter EA (2005) Skeletal muscle glucose uptake during exercise: how is it regulated? Physiology 20:260–270
Szent-Gyorgyi AG (2004) The early history of the biochemistry of muscle contraction. J Gen Physiol 123:631–641
Witczak CA, Sharoff CG, Goodyear LJ (2008) AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. Cell Mol Life Sci 65:3737–3755
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Da Poian, A.T., Castanho, M.A.R.B. (2015). Regulation and Integration of Metabolism During Physical Activity. In: Integrative Human Biochemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3058-6_10
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DOI: https://doi.org/10.1007/978-1-4939-3058-6_10
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-3057-9
Online ISBN: 978-1-4939-3058-6
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