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Loss, Degeneration, and Preservation of the Spiral Ganglion Neurons and Their Processes

Chapter
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 52)

Abstract

To maintain normal function, spiral ganglion neurons (SGNs) and their associated components require a healthy cochlear microenvironment including numerous molecular and cellular elements. This chapter reviews our current understanding of SGN loss and dysfunction with an emphasis on recent studies of primary degeneration of ganglion neurons and age-related auditory nerve loss and dysfunction. Results from animal models of the SGN degeneration and a discussion of possible approaches that could lead to the preservation of these neurons in vivo are given in this chapter. The complex interactions between SGNs and the cochlear microenvironment are important areas for future exploration to better understand the mechanisms of SGN degeneration and dysfunction.

Keywords

Age-related hearing loss Animal models Auditory physiology Glia Cell Death Excitotoxicity Neural degeneration Noise-induced hearing loss Preservation Primary auditory nerve Repair Spiral ganglion Spontaneous activities 

Notes

Acknowledgments

I thank Richard Schmiedt for his encouragement and invaluable suggestions on the scope of the chapter. Many others, Judy Dubno, Jayne Ahlstrom, Emily Franko-Tobin, Kenyaria Noble, Edward Krug, Rhett Chaplin, and the editors of the SHAR series, shared their expertise and provided constructive criticism during the preparation of the text. This work supported by grants NIH grants R01 DC012058 and P50 DC00422.

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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineMedical University of South CarolinaCharlestonUSA

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