Skip to main content
SpringerLink
Log in
Book cover

Oxygen Transport to Tissue XXXVII pp 201–207Cite as

Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors

  • Conference paper

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 876))

Abstract

The influence of changes in tumor oxygenation (monitored by EPR oximetry) on the uptake of 18F-FDG tracer was evaluated using micro-PET in two different human tumor models. The 18F-FDG uptake was higher in hypoxic tumors compared to tumors that present a pO2 value larger than 10 mmHg.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Dierckx RA, Van de Wiele C (2008) FDG uptake, a surrogate of tumour hypoxia? Eur J Nucl Med Mol Imaging 35:1544–1549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Mayer A, Höckel M, Wree A et al (2005) Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers. Clin Cancer Res 11:2768–2773

    Article  CAS  PubMed  Google Scholar 

  3. Mayer A, Höckel M, Vaupel P (2008) Endogenous hypoxia markers: case not proven! Adv Exp Med Biol 614:127–136

    Article  CAS  PubMed  Google Scholar 

  4. Thews O, Kelleher DK, Esser N et al (2003) Lack of association between tumor hypoxia, GLUT-1 expression and glucose uptake in experimental sarcomas. Adv Exp Med Biol 510:57–61

    Article  CAS  PubMed  Google Scholar 

  5. Jordan BF, Baudelet C, Gallez B (1998) Carbon-centered radicals as oxygen sensors for in vivo electron paramagnetic resonance: screening for an optimal probe among commercially available charcoals. Magn Reson Mater Phys Biol Med 7:121–129

    Article  CAS  Google Scholar 

  6. Gallez B, Jordan BF, Baudelet C et al (1999) Pharmacological modifications of the partial pressure of oxygen in murine tumors: evaluation using in vivo EPR. Magn Reson Med 42:627–630

    Article  CAS  PubMed  Google Scholar 

  7. Gallez B, Baudelet C, Jordan BF (2004) Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications. NMR Biomed 17:240–262

    Article  CAS  PubMed  Google Scholar 

  8. Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891–899

    Article  CAS  PubMed  Google Scholar 

  9. Sonveaux P, Végran F, Schroeder T et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930–3942

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Busk M, Horsman MR, Kristjansen PE et al (2008) Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. Int J Cancer 122:2726–2734

    Article  CAS  PubMed  Google Scholar 

  11. Busk M, Horsman MR, Jakobsen S et al (2008) Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage. Eur J Nucl Med Mol Imaging 35:2294–2303

    Article  CAS  PubMed  Google Scholar 

  12. Waki A, Fujibayashi Y, Yonekura Y et al (1997) Reassessment of FDG uptake in tumor cells: high FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production. Nucl Med Biol 24:665–670

    Article  CAS  PubMed  Google Scholar 

  13. Clavo AC, Brown RS, Wahl RL (1995) Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia. J Nucl Med 36:1625–1632

    CAS  PubMed  Google Scholar 

  14. Burgman P, Odonoghue JA, Humm JL et al (2001) Hypoxia-induced increase in FDG uptake in MCF7 cells. J Nucl Med 42:170–175

    CAS  PubMed  Google Scholar 

  15. Chan LW, Hapdey S, English S et al (2006) The influence of tumor oxygenation on (18)F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET). Radiat Oncol 1:3

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gagel B, Piroth M, Pinkawa M et al (2007) pO2 polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia? BMC Cancer 7:113

    Article  PubMed  PubMed Central  Google Scholar 

  17. de Geus-Oei LF, Kaanders JH, Pop LA et al (2006) Effects of hyperoxygenation on FDG-uptake in head-and-neck cancer. Radiother Oncol 80:51–56

    Article  PubMed  Google Scholar 

  18. Li XF, Ma Y, Sun X et al (2010) High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia. J Nucl Med 51:632–638

    Article  PubMed  PubMed Central  Google Scholar 

  19. Christian N, Deheneffe S, Bol A et al (2010) Is (18)F-FDG a surrogate tracer to measure tumor hypoxia? Comparison with the hypoxic tracer (14)C-EF3 in animal tumor models. Radiother Oncol 97:183–188

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by grants from the Belgian National Fund for Scientific Research (FNRS).

Author information

Authors and Affiliations

  1. Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium

    Marie-Aline Neveu & Bernard Gallez

  2. Radiation Oncology Department & Center for Molecular Imaging, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium

    Vanesa Bol, Anne Bol & Vincent Grégoire

Authors
  1. Marie-Aline Neveu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vanesa Bol
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anne Bol
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vincent Grégoire
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bernard Gallez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bernard Gallez .

Editor information

Editors and Affiliations

  1. Department of Medical Physics & Biomedical Engineering, University College London, London, UK

    Clare E. Elwell  & Terence S. Leung  & 

  2. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media, New York

About this paper

Cite this paper

Neveu, MA., Bol, V., Bol, A., Grégoire, V., Gallez, B. (2016). Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors. In: Elwell, C.E., Leung, T.S., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol 876. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3023-4_25

Download citation

Publish with us

Policies and ethics

Search

Navigation