Abstract
This paper discusses two kinds of regulation essential to the circulatory system: namely the regulation of blood flow and that of (systemic) arterial blood pressure. It is pointed out that blood flow requirements sub-serve the nutritional needs of the tissues, adequately catered for by keeping blood flow sufficient for the individual oxygen needs. Individual tissue oxygen requirements vary between tissue types, while highly specific for a given individual tissue. Hence, blood flows are distributed between multiple tissues, each with a specific optimum relationship between the rate of oxygen delivery (DO2) and oxygen consumption (VO2). Previous work has illustrated that the individual tissue blood flows are adjusted proportionately, where there are variations in metabolic rate and where arterial oxygen content (CaO2) varies. While arterial blood pressure is essential for the provision of a sufficient pressure gradient to drive blood flow, it is applicable throughout the arterial system at any one time. Furthermore, It is regulated independently of the input resistance to individual tissues (local arterioles), since they are regulated locally, that being the means by which the highly specific adequate local requirement for DO2 is ensured. Since total blood flow is the summation of all the individually regulated tissue blood flows cardiac inflow (venous return) amounts to total tissue blood flow and as the heart puts out what it receives cardiac output is therefore determined at the tissues. Hence, regulation of arterial blood pressure is independent of the distributed independent regulation of individual tissues. It is proposed here that mechanical features of arterial blood pressure regulation will depend rather on the balance between blood volume and venous wall tension, determinants of venous pressure. The potential for this explanation is treated in some detail.
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Starling EH (1923) The wisdom of the body: the Harveian oration. Br Med J ii:685–690
Guyton AC, Jones CE, Coleman TG (1973) Circulatory physiology: cardiac output and its regulation. W. B. Saunders, Philadelphia
Wolff CB (2007) Normal cardiac output, oxygen delivery and oxygen extraction. Adv Exp Med Biol 599:169–182
Wolff CB (2013) Oxygen delivery: the principal role of the circulation. Adv Exp Med Biol 789:37–42. doi:10.1007/978-1-4614-7411-1_6
Wolff CB (2003) Cardiac output, oxygen consumption and muscle oxygen delivery in submaximal exercise: normal and low O2 states. Adv Exp Med Biol 510:279–284
Wolff CB, Richardson N, Kemp O, Kuttler A, McMorrow R, Hart N, Imray CHE (2007) Near infra-red spectroscopy and arterial oxygen extraction at altitude. Adv Exp Med Biol 599:183–189
Ross JM, Linhart JW, Guyton AC (1962) Autoregulation of blood flow by oxygen lack. Am J Physiol 202:21–24
Ross JM, Fairchild HM, Weldy J et al (1962) Autoregulation of blood flow by oxygen lack. Am J Physiol 202(1):21–24
Donald DE, Shepherd JT (1964) Initial cardiovascular adjustment to exercise in dogs with chronic cardiac denervation. Am J Physiol 207(6):1325–1329
Mohrman DE, Heller LJ (1986) Cardiovascular physiology, 2nd edn. McGraw-Hill, New York
Guyenet PG (2006) The sympathetic control of blood pressure. Nat Rev Neurosci 7:335–346
Yamamoto J, Trippodo NC, Ishise S, Frolich ED (1980) Total vascular pressure-volume relationship in the conscious rat. Am J Physiol 238:H823–H828
Fink GD (2009) Sympathetic activity, vascular capacitance, and long-term regulation of arterial pressure. Hypertension 53:307–312
King AJ, Fink GD (2006) Chronic low-dose angiotensin ii infusion increases venomotor tone by neurogenic mechanisms. Hypertension 48:927–933. doi:10.1161/01.HYP.0000243799.84573.f8
Hottenstein OD, Kreuken DL (1987) Comparison of the frequency dependence of venous and arterial responses to sympathetic nerve stimulation in guinea pigs. J Physiol 384:153–167
Levick JR (1991) An introduction to cardiovascular physiology. Butterworth, New York/London
Ebert TJ, Muzi M, Berens R et al (1992) Sympathetic responses to induction of anesthesia in humans with propofol or etomidate. Anesthesiology 76(5):725–733
Elliott J (1997) Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction. J Vet Pharmacol Ther 20:308–317
Goodchild CS, Serrao JM (1989) Cardiovascular effects of propofol in the anaesthetized dog. Br J Anaesth 63:87–92
Lobo MD, Sobotka PA, Stanton A et al (2015) Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial. Lancet 385(9978):1634–1641
Sharpey-Schaffer EP (1963) Venous tone: effects of reflex changes, humoral agents and exercise. Br Med J 19(2):145–148
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Wolff, C.B. et al. (2016). A Discussion on the Regulation of Blood Flow and Pressure. In: Elwell, C.E., Leung, T.S., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol 876. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3023-4_16
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DOI: https://doi.org/10.1007/978-1-4939-3023-4_16
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