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Reduction in Cerebral Oxygenation After Prolonged Exercise in Hypoxia is Related to Changes in Blood Pressure

  • Masahiro HoriuchiEmail author
  • Shohei Dobashi
  • Masataka Kiuchi
  • Junko Endo
  • Katsuhiro Koyama
  • Andrew W. Subudhi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 876)

Abstract

We investigated the relation between blood pressure and cerebral oxygenation (COX) immediately after exercise in ten healthy males. Subjects completed an exercise and recovery protocol while breathing either 21 % (normoxia) or 14.1 % (hypoxia) O2 in a randomized order. Each exercise session included four sets of cycling (30 min/set, 15 min rest) at 50 % of altitude-adjusted peak oxygen uptake, followed by 60 min of recovery. After exercise, mean arterial pressure (MAP; 87 ± 1 vs. 84 ± 1 mmHg, average values across the recovery period) and COX (68 ± 1 % vs. 58 ± 1 %) were lower in hypoxia compared to normoxia (P < 0.001). Changes in MAP and COX were correlated during the recovery period in hypoxia (r = 0.568, P < 0.001) but not during normoxia (r = 0.028, not significant). These results demonstrate that reductions in blood pressure following exercise in hypoxia are (1) more pronounced than in normoxia, and (2) associated with reductions in COX. Together, these results suggest an impairment in cerebral autoregulation as COX followed changes in MAP more passively in hypoxia than in normoxia. These findings could help explain the increased risk for postexercise syncope at high altitude.

Keywords

Postexercise syncope High altitude Cerebral autoregulation Vasodilation Near infrared spectroscopy 

Notes

Acknowledgments

The authors thank all participants for their time and effort. This study was supported by the Japan Society for the Promotion of the Science (No. 26440268 to M.H. and No. 25350810 to K.K).

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Copyright information

© Springer Science+Business Media, New York 2016

Authors and Affiliations

  • Masahiro Horiuchi
    • 1
    Email author
  • Shohei Dobashi
    • 1
  • Masataka Kiuchi
    • 1
  • Junko Endo
    • 1
  • Katsuhiro Koyama
    • 1
  • Andrew W. Subudhi
    • 2
  1. 1.Division of Human Environmental ScienceMt. Fuji Research InstituteFujiyoshidaJapan
  2. 2.Department of BiologyUniversity of Colorado Colorado SpringsColorado SpringsUSA

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