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Junctional Signaling in Endothelial Cells

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Endothelial Signaling in Development and Disease

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Abstract

Cell-to-cell junctions not only support the crucial function of mutual adhesion among the cells of the endothelial layer but they also harmonize the signaling and transcription program of each individual cell to its adhesive interactions with neighboring cells. Such coordination is achieved through association with cell-to-cell junctions of multiprotein complexes that can start specific signaling programs, depending on the state of cell-to-cell junctions, and that can also modulate the organization of cell-to-cell junctions themselves. Such reciprocity between adhesion and signaling is crucial for the physiological activity of the endothelium.

On the other hand, dysfunctions of endothelial cell-to-cell junctions appear to play central roles in several vascular pathologies. The molecular basis of such defects starts to be recognized and delineates endothelial cell-to-cell junctions as possible pharmacological targets for therapeutic interventions.

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Authors and Affiliations

  1. FIRC Institute for Molecular Oncology Fondazione, Via Adamello 16, 20139, Milan, Italy

    Dr. Luca Bravi & Dr. Maria Grazia Lampugnani

  2. Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy

    Dr. Maria Grazia Lampugnani

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  1. Dr. Luca Bravi
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Correspondence to Maria Grazia Lampugnani .

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  1. Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006, Johannes Gutenberg University School of Medicine, Mainz, Germany

    Mirko HH Schmidt

  2. Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

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Bravi, L., Lampugnani, M. (2015). Junctional Signaling in Endothelial Cells. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_6

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