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Development and Differentiation of the Lymphatic Vascular System

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Endothelial Signaling in Development and Disease

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Abstract

The lymphatic vasculature is critical for the maintenance of homeostasis, and performs essential roles in the trafficking of fluids, immune cells, and dietary fats. This importance is highlighted by the contribution of the lymphatic vasculature to several human diseases, including lymphedema, tumor metastasis, and inflammation. In this chapter, we seek to review basic principles of lymphatic vessel biology and discuss the current understanding of molecular mechanisms involved in lymphatic endothelial cell identity, embryonic and postnatal lymphatic development and maturation. Knowledge of the underlying molecular mechanisms controlling lymphatic vessel biology may lead to targeted treatments to improve patient care in the future.

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Authors and Affiliations

  1. Department of Oncology, University of Lausanne, Epalinges, 1006, Lausanne, Switzerland

    Jeremiah Bernier-Latmani, Amélie Sabine & Tatiana V. Petrova

  2. Swiss Institute for Cancer Research, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland

    Tatiana V. Petrova

Authors
  1. Jeremiah Bernier-Latmani
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  2. Amélie Sabine
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  3. Tatiana V. Petrova
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Correspondence to Tatiana V. Petrova .

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  1. Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006, Johannes Gutenberg University School of Medicine, Mainz, Germany

    Mirko HH Schmidt

  2. Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

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Bernier-Latmani, J., Sabine, A., Petrova, T. (2015). Development and Differentiation of the Lymphatic Vascular System. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_5

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