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Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes

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Abstract

Intermediate filaments (IFs) are cytoskeletal structures that primarily maintain the structural and mechanical integrity of cells and tissues. However, recent evidence reveals that IFs participate in a number of critical cellular processes, such as regulation of the cytoplasmic architecture, cell growth, cell migration, organelle positioning, signaling, and/or regulating transcription. Although IFs have been studied in various somatic cells of many species, we focus here mainly on data obtained from studies in mammalian ovarian follicles and oocytes. The ovarian follicles contain keratin, vimentin, desmin, nestin, glial fibrillary acidic protein (GFAP) and neurofilaments. The characteristic structural features and expression patterns of the different members of the IF protein family will be discussed in mammalian ovarian tissues and oocytes.

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Numbers 17580243, 21580340 and 24580403. The author thanks Mr. Taiki Sato, Mr. Yosuke Shiozaki and Ms. Manami Sumida for technical assistance.

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  1. Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori, 036-8561, Japan

    Hiroyuki Suzuki

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  1. Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, Missouri, USA

    Heide Schatten

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Suzuki, H. (2015). Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes. In: Schatten, H. (eds) The Cytoskeleton in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2904-7_13

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