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How Do Glucocorticoids Regulate Lipid Metabolism?

  • Chapter
Glucocorticoid Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 872))

Abstract

Glucocorticoids (GCs) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical checkpoints in the hormonal control of energy homeostasis in mammals. Whereas physiological levels of GCs are required for proper metabolic control, aberrant GC action has been linked to a variety of severe metabolic diseases, including type 2 diabetes and obesity. As a member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are in many cases associated with lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic lipid homeostasis. Thus, this chapter focuses on the current knowledge of GC/GR function in lipid handling and its implications for systemic metabolic dysfunction.

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Authors and Affiliations

  1. Department of Molecular Metabolic Control, German Cancer Research Center, Center for Molecular Biology and University Hospital Heidelberg, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Roldan M. de Guia Ph.D. & Stephan Herzig Ph.D.

Authors
  1. Roldan M. de Guia Ph.D.
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  2. Stephan Herzig Ph.D.
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Correspondence to Stephan Herzig Ph.D. .

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Editors and Affiliations

  1. Department of Nutritional Science & Toxicology, University of California Berkeley, Berkeley, California, USA

    Jen-Chywan Wang

  2. Division of Endocrinology Metabolism & Lipid Research, Department of Internal Medicine, Washington University School of Medicine Division of Endocrinology, St. Louis, Missouri, USA

    Charles Harris

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© 2015 Springer Science+Business Media New York

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de Guia, R.M., Herzig, S. (2015). How Do Glucocorticoids Regulate Lipid Metabolism?. In: Wang, JC., Harris, C. (eds) Glucocorticoid Signaling. Advances in Experimental Medicine and Biology, vol 872. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2895-8_6

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