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Precision Molecular Pathology of Breast Cancer pp 119–136Cite as

Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy

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Part of the book series: Molecular Pathology Library ((MPLB,volume 10))

Abstract

Human epidermal growth factor receptor-2 (HER2) is a well-studied member of epidermal growth factor receptor (EGFR) family. HER2 gene amplification and/or protein overexpression can be observed in many cancers of epithelial origin, including breast carcinoma. In breast carcinomas, HER2 gene amplification serves as a negative prognostic factor and its presence is usually associated with a more aggressive clinical behavior. Currently, there are several medications, including monoclonal antibodies or small molecules that target this receptor on the surface of tumoral cells. Targeted therapy improves patients’ response rates and survival and increase time to progression when used alone or in combination with other therapeutic modalities. As the accurate determination of HER2 gene status is very important for proper selection of treatment, this can be achieved by several methods, such as immunohistochemistry and/or in situ hybridization.

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Authors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, UMassMemorial Medical Center, Three Biotech, One Innovation Drive, Worcester, MA, 01605, USA

    Ali Sakhdari, Lloyd Hutchinson & Ediz F. Cosar

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  1. Ali Sakhdari
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  2. Lloyd Hutchinson
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  3. Ediz F. Cosar
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Correspondence to Ediz F. Cosar .

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Editors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, UMassMemorial Medical Center, Worcester, Massachusetts, USA

    Ashraf Khan

  2. Department of Histopathology, University of Nottingham, Nottingham, United Kingdom

    Ian O. Ellis

  3. Leeds Institute of Cancer and Pathology, St. James University Hospital, Leeds, West Yorkshire, United Kingdom

    Andrew M. Hanby

  4. Department of Pathology, University of Massachusetts Medical School, UMassMemorial Medical Center, Worcester, Massachusetts, USA

    Ediz F. Cosar

  5. Department of Histopathology, University of Nottingham, Nottingham, United Kingdom

    Emad A. Rakha

  6. Department of Pathology, University of Massachusetts Medical School, UMassMemorial Medical Center, Worcester, Massachusetts, USA

    Dina Kandil

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Sakhdari, A., Hutchinson, L., Cosar, E.F. (2015). Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy. In: Khan, A., Ellis, I., Hanby, A., Cosar, E., Rakha, E., Kandil, D. (eds) Precision Molecular Pathology of Breast Cancer. Molecular Pathology Library, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2886-6_9

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