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Neuroendocrine Neoplasms of the Thymus

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Part of the book series: Atlas of Anatomic Pathology ((AAP))

Abstract

Neoplastic neuroendocrine proliferations of the mediastinum can originate from neuroendocrine cells that are native to the thymus, or they may arise from extra-adrenal paraganglia ectopically located in the mediastinum (i.e., paragangliomas).

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Suggested Reading

  • Cardillo G, Rea F, Lucci M, Paul MA, Margoritora S, Carleo F, et al. Primary neuroendocrine tumors of the thymus: a multicenter experience of 35 patients. Ann Thorac Surg. 2012;94:241–5.

    Article  PubMed  Google Scholar 

  • Chetty R, Batitang S, Govender D. Large cell neuroendocrine carcinoma of the thymus. Histopathology. 1997;11:274–6.

    Article  Google Scholar 

  • Crona J, Bjorklund P, Welin S, Kozlovacki G, Oberg K, Granberg D. Treatment, prognostic markers and survival in thymic neuroendocrine tumors. A study from a single tertiary referral centre. Lung Cancer. 2013;79:289–93.

    Article  PubMed  Google Scholar 

  • Economopoulus GC, Lewis Jr JW, Lee MW, Silverman NA. Carcinoid tumors of the thymus. Ann Thorac Surg. 1990;50:58–61.

    Article  Google Scholar 

  • Floros D, Dosios T, Tsourdis A, Yiatromanolakis N. Carcinoid tumor of the thymus with multiple endocrine adenomatosis. Pathol Res Pract. 1982;175:404–9.

    Article  CAS  PubMed  Google Scholar 

  • Gal AA, Kornstein MJ, Cohen C, Duarte IG, Miller JI, Mansour KA. Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study. Ann Thorac Surg. 2001;72:1179–82.

    Article  CAS  PubMed  Google Scholar 

  • Klemm KM, Moran CA, Suster S. Pigmented thymic carcinoids. A clinicopathological and immunohistochemical study of 2 cases. Mod Pathol. 1999;12:946–8.

    CAS  PubMed  Google Scholar 

  • Montpreville VT, Machiarini P, Dulmet E. Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of 14 cases. J Thorac Cardiovasc Surg. 1996;111:134–41.

    Article  PubMed  Google Scholar 

  • Moran CA, Suster S. Angiomatous neuroendocrine carcinoma of the thymus: report of a distinctive morphological variant of neuroendocrine tumor of the thymus resembling a vascular neoplasm. Hum Pathol. 1999a;30:635–9.

    Article  CAS  PubMed  Google Scholar 

  • Moran CA, Suster S. Spindle cell neuroendocrine carcinomas of the thymus (spindle cell thymic carcinoid): a clinicopathologic and immunohistochemical study of seven cases. Mod Pathol. 1999b;12:587–91.

    CAS  PubMed  Google Scholar 

  • Moran CA, Suster S. Neuroendocrine carcinoma (carcinoid) of the thymus: A clinicopathologic analysis of 80 cases. Am J Clin Pathol. 2000a;114:100–10.

    Article  CAS  PubMed  Google Scholar 

  • Moran CA, Suster S. Primary neuroendocrine carcinoma (carcinoid) of the thymus with prominent oncocytic features: clinicopathologic study of 22 cases. Mod Pathol. 2000b;13:489–94.

    Article  CAS  PubMed  Google Scholar 

  • Moran CA, Suster S. Thymic neuroendocrine carcinomas with combined features ranging from well-differentiated (carcinoid) to small cell carcinoma: a clinicopathologic and immunohistochemical study of 11 cases. Am J Clin Pathol. 2000c;113:345–50.

    Article  CAS  PubMed  Google Scholar 

  • Moran CA, Suster S. Cystic well-differentiated neuroendocrine carcinoma (carcinoid tumor). A clinicopathologic and immunohistochemical study of two cases. Am J Clin Pathol. 2006a;126:377–80.

    Article  PubMed  Google Scholar 

  • Moran CA, Suster S. Spectrum of pathologic features in neuroendocrine neoplasms of the mediastinum. Pathol Case Rev. 2006b;11:199–205.

    Article  Google Scholar 

  • Moran CA, Suster S, Fishback N, Koss MN. Mediastinal paragangliomas: a clinicopathologic and immunohistochemical study of 16 cases. Cancer. 1993;72:2358–64.

    Article  CAS  PubMed  Google Scholar 

  • Olson JL, Salyer WR. Mediastinal paragangliomas (aortic body tumor): A report of four cases and a review of the literature. Cancer. 1978;41:2405–12.

    Article  CAS  PubMed  Google Scholar 

  • Rosai J, Levine G, Weber WR, Higa E. Carcinoid tumors and oat cell carcinomas of the thymus. Pathol Annu. 1977;2:33–62.

    Google Scholar 

  • Saito T, Kimoto M, Nakai S, Ikoma A, Toyoshima H, Kawakami M, et al. Ectopic ACTH syndrome associated with large cell neuroendocrine carcinoma of the thymus. Intern Med. 2011;50:1471–5.

    Article  CAS  PubMed  Google Scholar 

  • Suster S, Moran CA. Thymic carcinoid with prominent mucinous stroma: report of a distinctive morphologic variant of thymic neuroendocrine neoplasm. Am J Surg Pathol. 1995;19:1277–85.

    Article  CAS  PubMed  Google Scholar 

  • Suster S, Moran CA. Neuroendocrine neoplasms of the mediastinum. Am J Clin Pathol. 2001;115(S):17–27.

    Google Scholar 

  • Suster S, Rosai J. Thymic carcinoma. A clinicopathologic study of 60 cases. Cancer. 1991;67:1025–32.

    Article  CAS  PubMed  Google Scholar 

  • Tiffet O, Nicholson AG, Ladas G, Sheppard MN, Goldstraw P. A clinicopathologic study of 12 cases of neuroendocrine tumors arising in the thymus. Chest. 2003;124:141–6.

    Article  PubMed  Google Scholar 

  • Valli M, Fabris GA, Dewar A, Chikte S, Fisher C, Corrin B, Sheppard MN. Atypical carcinoid tumor of the thymus: a study of eight cases. Histopathology. 1994;24:371–5.

    Article  CAS  PubMed  Google Scholar 

  • Wick MR, Carney JA, Bernatz PE, Brown LR. Primary mediastinal carcinoid tumors. Am J Surg Pathol. 1982;6:195–205.

    Article  CAS  PubMed  Google Scholar 

  • Wick MR, Scheithauer BW. Oat cell carcinoma of the thymus. Cancer. 1982;49:1652–7.

    Article  CAS  PubMed  Google Scholar 

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Suster, S. (2015). Neuroendocrine Neoplasms of the Thymus. In: Atlas of Mediastinal Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2674-9_3

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  • DOI: https://doi.org/10.1007/978-1-4939-2674-9_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2673-2

  • Online ISBN: 978-1-4939-2674-9

  • eBook Packages: MedicineMedicine (R0)

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