Skip to main content

Development of Personalized Medicine

  • Chapter
  • First Online:
Textbook of Personalized Medicine

Abstract

In conventional medical practice, the physicians rely on their personal experience in treating patients. In spite of advances in basic medical sciences and introduction of new technologies, the physicians continue to rely on their judgment and sometimes intuition because practice of medicine is an art as well as a science.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adida B, Kohane IS. GenePING: secure, scalable management of personal genomic data. BMC Genomics. 2006;7:93.

    Article  PubMed Central  PubMed  Google Scholar 

  • Blumenthal D, Tavenner M. The “meaningful use” regulation for electronic health records. N Engl J Med. 2010;363:501–4.

    Article  CAS  PubMed  Google Scholar 

  • Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–5.

    Google Scholar 

  • Dancey JE, Bedard PL, Onetto N, Hudson TJ. The genetic basis for cancer treatment decisions. Cell. 2012;148:409–20.

    Article  CAS  PubMed  Google Scholar 

  • DesRoches CM, Campbell EG, Rao SR, et al. Electronic health records in ambulatory care – a national survey of physicians. NEJM. 2008;359:50–60.

    Article  CAS  PubMed  Google Scholar 

  • Downing GJ, Boyle SN, Brinner KM, Osheroff JA. Information management to enable personalized medicine: stakeholder roles in building clinical decision support. BMC Med Inform Decis Mak. 2009;9:44.

    Article  PubMed Central  PubMed  Google Scholar 

  • Fries S, Grosser T, Price TS, et al. Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology. 2006;130:55–64.

    Article  CAS  PubMed  Google Scholar 

  • Haga SB, LaPointe NM. The potential impact of pharmacogenetic testing on medication adherence. Pharmacogenomics J. 2013;13:481–3.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hamburg MA, Collins FS. The path to personalized medicine. NEJM. 2010;363:301–4.

    Article  CAS  PubMed  Google Scholar 

  • Hudson KL. Genomics, health care, and society. N Engl J Med. 2011;365:1033–41.

    Article  CAS  PubMed  Google Scholar 

  • Jha AK, DesRoches CM, Campbell EG, et al. Use of electronic health records in U.S. hospitals. NEJM. 2009;360:1628–38.

    Article  CAS  PubMed  Google Scholar 

  • Kellermann AL, Jones SS. What it will take to achieve the as-yet-unfulfilled promises of health information technology. Health Aff. 2013;32:63–8.

    Article  Google Scholar 

  • Kent DM, Rothwell PM, Ioannidis JP, Altman DG, Hayward RA. Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials. 2010;11:85.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kho AN, Pacheco JA, Peissig PL, et al. Electronic medical records for genetic research: results of the eMERGE consortium. Sci Transl Med. 2011;3:79re1.

    PubMed Central  PubMed  Google Scholar 

  • Kohane IS, Masys DR, Altman RB. The incidentalome: a threat to genomic medicine. JAMA. 2006;296:212–5.

    Article  CAS  PubMed  Google Scholar 

  • Lai TL, Lavori PW, Shih MC, Sikic BI. Clinical trial designs for testing biomarker-based personalized therapies. Clin Trials. 2012;9:141–54.

    Article  PubMed Central  PubMed  Google Scholar 

  • Mooser V, Currat C. The Lausanne Institutional Biobank: a new resource to catalyse research in personalised medicine and pharmaceutical sciences. Swiss Med Wkly. 2014;144:w14033.

    PubMed  Google Scholar 

  • Moynihan R, Henry D, Moons KG. Using evidence to combat overdiagnosis and overtreatment: evaluating treatments, tests, and disease definitions in the time of too much. PLoS Med. 2014;11:e1001655.

    Article  PubMed Central  PubMed  Google Scholar 

  • Scheuner MT, de Vries H, Kim B, et al. Are electronic health records ready for genomic medicine? Genet Med. 2009;11:510–7.

    Article  PubMed  Google Scholar 

  • Simon R. Designs and adaptive analysis plans for pivotal clinical trials of therapeutics and companion diagnostics. Exp Opin Med Diagn. 2008;2:721–9.

    Article  Google Scholar 

  • Stachnik A, Yuen T, Iqbal J, et al. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer. Proc Natl Acad Sci U S A. 2014;111:17995–8000.

    Article  CAS  PubMed  Google Scholar 

  • Wang W, Kim SH, El-Deiry WS. Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. Proc Natl Acad Sci U S A. 2006;103:11003–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wing K, Douglas I, Bhaskaran K, et al. Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records. Drug Discov Today. 2014;19:361–6.

    Article  PubMed  Google Scholar 

  • Yang JY, Yang MQ, Zhu MM, et al. Promoting synergistic research and education in genomics and bioinformatics. BMC genomics 2008;9 Suppl 1:I1.

    Google Scholar 

  • Yao L, Zhang Y, Li Y, et al. Electronic health records: implications for drug discovery. Drug Discov Today. 2011;16:594–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Jain, K.K. (2015). Development of Personalized Medicine. In: Textbook of Personalized Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2553-7_20

Download citation

Publish with us

Policies and ethics