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Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 pp 177–198Cite as

Fungal Secondary Metabolism in the Light of Animal–Fungus Interactions: From Mechanism to Ecological Function

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Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Animal grazing is a pervasive ecological factor threatening fungal fitness. This review summarizes the different approaches that have been used to test whether secondary metabolites serve as anti-fungivore defense agents. Assuming that secondary metabolites at least in part have evolved to mediate resistance against fungivores, this review evaluates the pros and cons of (1) using long-standing toxicity assays, (2) considering natural variation in fungal secondary metabolite formation, and (3) experiments with transgenic mutant fungi. Connecting inducible changes in fungal, molecular, genetic, biochemical, and morphological properties with fungivore behavioral and fitness assays is a new approach to investigate the functional relationship between secondary metabolite regulation and resistance against fungivores. Strengthening this dynamic view on fungus–fungivore interactions will certainly pave the way for a deeper understanding of how known (and still unknown) regulatory mechanisms act in concert with the biosynthesis of anti-fungivore compounds and the extent to which both constitutive and inducible variations in fungal chemical diversity represent an adaptation to animal grazing.

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Acknowledgments

The work of M. R. is funded by the German Research Foundation (DFG), grant numbers RO3523/3-1, 3-2 and by the Georg-August-University of Göttingen.

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  1. J.F. Blumenbach Institute of Zoology and Anthropology, Georg-August-University Göttingen, Berliner Strasse 28, 37073, Göttingen, Germany

    Marko Rohlfs

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Correspondence to Marko Rohlfs .

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  1. Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

    Susanne Zeilinger

  2. Department of Molecular Biology, University of León, León, Spain

    Juan-Francisco Martín

  3. Biomedicine and Biopharma Area (INBIOTEC), Instituto de Biotecnología de León, León, Spain

    Carlos García-Estrada

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Rohlfs, M. (2015). Fungal Secondary Metabolism in the Light of Animal–Fungus Interactions: From Mechanism to Ecological Function. In: Zeilinger, S., Martín, JF., García-Estrada, C. (eds) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2. Fungal Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2531-5_9

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