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Fungal Chemotaxonomy

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Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

MaSny chemotaxonomical methods have been suggested since the first chemical tests were used on basidiomycetes and lichens. Effective separation techniques, especially ultra-high performance liquid chromatography (UHPLC), and highly sensitive detection methods have been developed, especially mass spectrometric detection and diode array detection. Significant developments in biomolecular methods have made taxonomy and chemotaxonomy a rapidly developing field of science. Apart from DNA nucleotide sequences, the most studied molecules have been secondary metabolites (small molecule extrolites or natural products), and a large number of chemical studies have been made using profiles of extrolites, often in conjunction with fungal morphology, physiology, and molecular sequencing techniques, in a polyphasic approach to classification and identification. Species of filamentous fungi produce highly specific profiles of secondary metabolites, but the choice of growth and production media is very important to get as many extrolites expressed as possible. Many of these extrolites are promising drug lead candidates, or basis for other industrially usable compounds, making genomics and epigenetics important research fields in order to discover new biotechnological products.

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  1. Department of Systems Biology, Technical University of Denmark, Søltofts Plads Building 221, 2800, Kongens Lyngby, Denmark

    Jens C. Frisvad PhD, Dr.Techn

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  1. Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

    Susanne Zeilinger

  2. Department of Molecular Biology, University of León, León, Spain

    Juan-Francisco Martín

  3. Biomedicine and Biopharma Area (INBIOTEC), Instituto de Biotecnología de León, León, Spain

    Carlos García-Estrada

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Frisvad, J. (2015). Fungal Chemotaxonomy. In: Zeilinger, S., Martín, JF., García-Estrada, C. (eds) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2. Fungal Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2531-5_7

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