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Epigenetics of Fungal Secondary Metabolism Related Genes

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Book cover Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Fungal secondary metabolites play multiple biological roles in development, virulence, defense, adaptation, and stress response. Many of these low-molecular-mass compounds are of intense interest to humankind due to their economic applications (antibiotics and drugs) and/or adverse effects (mycotoxins). Many filamentous fungal secondary metabolites are synthesized by enzymes and related regulator(s) are encoded by clustered genes. Expression of these clusters are governed by various transcription factors and signaling elements. Recent studies have further revealed that fungal secondary metabolite genes are subject to epigenetic regulation. This chapter presents a concise summary of the epigenetic modifications and remodeling of the genes associated with fungal secondary metabolism, focusing on the genetic elements involved in epigenetic regulation, including HepA, (LaeA), complex proteins associated with Set1 (COMPASS) complex, histone deacetylases (HDACs), Spt-Ada-Gcn5-acetyltransferase (SAGA/ADA) complex, and small ubiquitin-like modifier (SUMO). Finally, the current applications of these epigenetic regulators are discussed.

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Acknowledgements

We thank Dr. Ellin Doyle for critically reviewing the manuscript. This work was supported by USDA Hatch (WIS01665) and the Intelligent Synthetic Biology Center of Global Frontier Project (2011-0031955) funded by the Ministry of Education, Science and Technology grants to JHY.

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Authors and Affiliations

  1. Department of Bacteriology and Genetics, University of Wisconsin-Madison, 1550 Linden Drive, 53706, Madison, WI, USA

    Ming-Yueh Wu MS & Jae-Hyuk Yu MS, PhD

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  1. Ming-Yueh Wu MS
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  2. Jae-Hyuk Yu MS, PhD
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Correspondence to Jae-Hyuk Yu MS, PhD .

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  1. Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

    Susanne Zeilinger

  2. Department of Molecular Biology, University of León, León, Spain

    Juan-Francisco Martín

  3. Biomedicine and Biopharma Area (INBIOTEC), Instituto de Biotecnología de León, León, Spain

    Carlos García-Estrada

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Wu, MY., Yu, JH. (2015). Epigenetics of Fungal Secondary Metabolism Related Genes. In: Zeilinger, S., Martín, JF., García-Estrada, C. (eds) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2. Fungal Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2531-5_3

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