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Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 pp 235–252Cite as

Biosynthesis and Molecular Genetics of Peptaibiotics—Fungal Peptides Containing Alpha, Alpha-Dialkyl Amino Acids

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Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Peptaibiotics are peptide secondary metabolites rich in alpha, alpha-dialkyl amino acids from filamentous fungi, especially the members of the genus Trichoderma (anamorph of Hypocrea). In contrast to the rapid progress in our understanding of peptaibiotics conformation, structural properties and mode of action with lipid membranes, knowledge available on the molecular genetics involved in the biosynthesis of peptaibiotics is limited, particularly the regulation of biosynthesis. Similar to other nonribosomal peptides, microheterogeneous peptaibiotics are synthesized by nonribosomal peptide synthetases (NRPSs) via the multiple-carrier thiotemplate mechanism. Biochemical and genetic evidence has yielded insight into the biosynthesis mechanism and led to a better understanding of the biosynthesis of peptaibiotics. However, still much needs to be learned about substrate selectivity and the regulation of peptaibiotics biosynthesis.

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Acknowledgments

This work was supported by the Hi-Tech Research and Development program of China (2011AA090704), National Natural Science Foundation of China (31270064, 31100039) and Program of Shandong for Taishan Scholars (2009TS079).

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Authors and Affiliations

  1. State Key Laboratory of Microbial Technology, Shandong University, Shandanan Road No. 27, 250100, Jinan, Republic of China

    Xiao-Yan Song PhD, Bin-Bin Xie PhD, Xiu-Lan Chen PhD & Yu-Zhong Zhang PhD

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  1. Xiao-Yan Song PhD
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Correspondence to Yu-Zhong Zhang PhD .

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  1. Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

    Susanne Zeilinger

  2. Department of Molecular Biology, University of León, León, Spain

    Juan-Francisco Martín

  3. Biomedicine and Biopharma Area (INBIOTEC), Instituto de Biotecnología de León, León, Spain

    Carlos García-Estrada

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Song, XY., Xie, BB., Chen, XL., Zhang, YZ. (2015). Biosynthesis and Molecular Genetics of Peptaibiotics—Fungal Peptides Containing Alpha, Alpha-Dialkyl Amino Acids. In: Zeilinger, S., Martín, JF., García-Estrada, C. (eds) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2. Fungal Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2531-5_11

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