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Gene Therapy for HIV and Chronic Infections pp 149–167Cite as

Vector-Mediated Antibody Gene Transfer for Infectious Diseases

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Part of the book series: Advances in Experimental Medicine and Biology ((ASGCT,volume 848))

Abstract

This chapter discusses the emerging field of vector-mediated antibody gene transfer as an alternative vaccine for infectious disease, with a specific focus on HIV. However, this methodology need not be confined to HIV-1; the general strategy of vector-mediated antibody gene transfer can be applied to other difficult vaccine targets like hepatitis C virus, malaria, respiratory syncytial virus, and tuberculosis. This approach is an improvement over classical passive immunization strategies that administer antibody proteins to the host to provide protection from infection. With vector-mediated gene transfer, the antibody gene is delivered to the host, via a recombinant adeno-associated virus (rAAV) vector; this in turn results in long-term endogenous antibody expression from the injected muscle that confers protective immunity. Vector-mediated antibody gene transfer can rapidly move existing, potent broadly cross-neutralizing HIV-1-specific antibodies into the clinic. The gene transfer products demonstrate a potency and breadth identical to the original product. This strategy eliminates the need for immunogen design and interaction with the adaptive immune system to generate protection, a strategy that so far has shown limited promise.

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Authors and Affiliations

  1. Infectious Disease, The Children’s Hospital of Philadelphia, Abramson Research Center, Room 1216J, 3615 Civic Center Blvd., Philadelphia, PA, 19104, USA

    Bruce C. Schnepp Ph.D.

  2. Infectious Disease, The Children’s Hospital of Philadelphia, Abramson Research Center, Room 1216B, 3615 Civic Center Blvd., Philadelphia, PA, 19104, USA

    Philip R. Johnson M.D.

Authors
  1. Bruce C. Schnepp Ph.D.
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  2. Philip R. Johnson M.D.
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Correspondence to Philip R. Johnson M.D. .

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Editors and Affiliations

  1. University of Amsterdam, Amsterdam, The Netherlands

    Ben Berkhout

  2. The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Hildegund C.J. Ertl

  3. University of the Witwatersrand, Johannesburg, South Africa

    Marc S. Weinberg

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© 2015 American Society of Gene and Cell Therapy

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Schnepp, B.C., Johnson, P.R. (2015). Vector-Mediated Antibody Gene Transfer for Infectious Diseases. In: Berkhout, B., Ertl, H., Weinberg, M. (eds) Gene Therapy for HIV and Chronic Infections. Advances in Experimental Medicine and Biology(), vol 848. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2432-5_8

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