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Spray-Drying of Biopharmaceuticals

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Lyophilized Biologics and Vaccines

Abstract

Spray-drying is an ubiquitous application in the pharmaceutical industry, and its use in drug formulation will only continue to expand. The combination of spray-drying and biopharmaceuticals succeeds because of the versatility and flexibility of spray-drying techniques to accommodate fragile biologics and specific formulation requirements. This chapter includes a basic overview of spray-drying, examines alternative spray-drying techniques, and compares and contrasts spray-drying and lyophilization for the preparation of biopharmaceutical formulations. Additionally, this chapter discusses the optimization of excipients, equipment, and operational parameters through specific examples of spray-drying for biopharmaceutical applications including pulmonary delivery, vaccine stabilization and delivery, and inhaled insulin formulations. Ultimately, the choice between lyophilization and spray-drying to produce a solid drug formulation should be guided by the particular biopharmaceutical in question and the desired delivery route.

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Authors and Affiliations

  1. College of Pharmacy, Center for Nanomedicine and Drug Delivery, Xavier University of Louisiana, 1 Drexel Drive, 70125, New Orleans, LA, USA

    Grace A. Ledet, Richard A. Graves, Levon A. Bostanian & Tarun K. Mandal

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  1. Grace A. Ledet
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  2. Richard A. Graves
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  1. Novartis Vaccines and Diagnostics, Holly Springs, North Carolina, USA

    Dushyant Varshney

  2. Novartis Vaccines and Diagnostics, Holly Springs, North Carolina, USA

    Manmohan Singh

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Ledet, G., Graves, R., Bostanian, L., Mandal, T. (2015). Spray-Drying of Biopharmaceuticals. In: Varshney, D., Singh, M. (eds) Lyophilized Biologics and Vaccines. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2383-0_12

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