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Combination BRAF-Directed Therapy and Immunotherapy

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BRAF Targets in Melanoma

Part of the book series: Cancer Drug Discovery and Development ((CDD&D,volume 82))

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Abstract

There have been two major advances in the treatment of metastatic melanoma within the past several years, including immunotherapy and BRAF-directed therapy. Both of these classes of therapy demonstrate survival benefit, but also have limitations as monotherapy with regard to overall response rate and/or durability of response. We have gained significant insight into mechanisms of response to BRAF-directed therapy and to potential synergy between these two treatment modalities. This chapter focuses on the limitations of each of these strategies as monotherapy, and provides the rationale for combining these therapies. Importantly, ongoing clinical trials of combined BRAF-directed therapy and immunotherapy are discussed, as well as considerations and future directions for therapy.

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Authors and Affiliations

  1. Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA

    Zachary A. Cooper & Jennifer A. Wargo

  2. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Zachary A. Cooper & Jennifer A. Wargo

  3. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

    Zain Ahmed

Authors
  1. Zachary A. Cooper
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  2. Zain Ahmed
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  3. Jennifer A. Wargo
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Correspondence to Jennifer A. Wargo .

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Editors and Affiliations

  1. Center for Melanoma, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA

    Ryan J. Sullivan

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Cooper, Z., Ahmed, Z., Wargo, J. (2015). Combination BRAF-Directed Therapy and Immunotherapy. In: Sullivan, R. (eds) BRAF Targets in Melanoma. Cancer Drug Discovery and Development, vol 82. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2143-0_8

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  • DOI: https://doi.org/10.1007/978-1-4939-2143-0_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2142-3

  • Online ISBN: 978-1-4939-2143-0

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