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Systems Biology of Platelet–Vessel Wall Interactions

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A Systems Biology Approach to Blood

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 844))

Abstract

Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel’s breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.

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Acknowledgments

Research of Mark Alber and Oleg Kim reported in this publication was supported by NIH U01HL116330, Yolande Chen by an American Heart Association Post-Doctoral Fellowship, and Seth Corey by NIH R21HL106462.

Author information

Authors and Affiliations

  1. RH Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Rm 5-220, 303 E. Superior St., 60611, Chicago, IL, USA

    Yolande Chen

  2. Departments of Pediatrics and Cell & Molecular Biology, Northwestern University Feinberg School of Medicine and Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Seth Joel Corey

  3. Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA

    Oleg V. Kim & Mark S. Alber

  4. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Mark S. Alber

Authors
  1. Yolande Chen
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  2. Seth Joel Corey
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  3. Oleg V. Kim
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  4. Mark S. Alber
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Corresponding author

Correspondence to Yolande Chen .

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Editors and Affiliations

  1. Departments of Pediatrics and Cell & Molecular Biology, Northwestern University Feinberg School of Medicine and Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA

    Seth Joel Corey

  2. Department of Statistics, Rice University, Houston, Texas, USA

    Marek Kimmel

  3. Northwestern University Comprehensive Cancer Center, Evanston, Illinois, USA

    Joshua N. Leonard

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Chen, Y., Corey, S., Kim, O., Alber, M. (2014). Systems Biology of Platelet–Vessel Wall Interactions. In: Corey, S., Kimmel, M., Leonard, J. (eds) A Systems Biology Approach to Blood. Advances in Experimental Medicine and Biology, vol 844. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2095-2_5

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