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Sleep, Cognitive Dysfunction, and Dementia

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Abstract

Sleep is vital to normal cognitive functioning, especially for the formation and consolidation of new memories. Altered circadian rhythm and sleep complaints are common in the aging population, especially in those with dementia, and sleep disturbances may further impact cognitive functioning in patients with dementia. Recent evidence also suggests that disturbed sleep and hypoxemia-related to sleep-disordered breathing may play a role in the development of dementia. Timely recognition and treatment of sleep disturbances may provide an avenue to improve memory and cognitive functioning and quality of life in patients with dementia.

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References

  1. Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimers Dement. 2012;8:131–68.

    Article  Google Scholar 

  2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. (text rev.). Washington, DC: American Psychiatric Press; 2000.

    Google Scholar 

  3. Plassman BL, Langa KM, Fisher GG, et al Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1–2):125–32.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Hartley, D. (1801). Observations on Man, His frame, his deity, and his expectations (1749/)6691. Gainesville: Scholars Facsimile Reprint.

    Google Scholar 

  5. Stickgold R. Sleep-dependent memory consolidation. Nature. 2005;437(7063):1272–8.

    Article  CAS  PubMed  Google Scholar 

  6. Ancoli-Israel S. Sleep and its disorders in aging populations. Sleep Med. 2009;Suppl 1:S7–11.

    Google Scholar 

  7. McCurry SM, Ancoli-Israel S. Sleep dysfunction in Alzheimer’s disease and other dementias. Curr Treat Options Neurol. 2003;5(3):261–72.

    Article  PubMed  Google Scholar 

  8. Moran M, Lynch CA, Walsh C, et al. Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med. 2005;6(4):347–52.

    Article  PubMed  Google Scholar 

  9. Rongve A, Boeve BF, Aarsland D. Frequency and correlates of caregiver-reported sleep disturbances in a sample of persons with early dementia. J Am Geriatr Soc. 2010;58(3):480–6.

    Article  PubMed  Google Scholar 

  10. Bonnet MH. Effect of sleep disruption on sleep, performance, and mood. Sleep. 1985;8(1):11–9.

    CAS  PubMed  Google Scholar 

  11. Haimov I, Hanuka E, Horowitz Y. Chronic insomnia and cognitive functioning among older adults. Behav Sleep Med. 2008;6(1):32–54.

    Article  PubMed  Google Scholar 

  12. Hornung OP, Danker-Hopfe H, Heuser I. Age-related changes in sleep and memory: commonalities and interrelationships. Exp Gerontol. 2005;40(4):279–85.

    Article  PubMed  Google Scholar 

  13. Jones K, Harrison Y. Frontal lobe function, sleep loss and fragmented sleep. Sleep Med Rev. 2001;5(6):463–75.

    Article  PubMed  Google Scholar 

  14. Kundermann B, Thum A, Rocamora R, et al. Comparison of polysomnographic variables and their relationship to cognitive impairment in patients with Alzheimer’s disease and frontotemporal dementia. J Psychiatr Res. 2011;45(12):1585–92.

    Article  PubMed  Google Scholar 

  15. Maquet P. The role of sleep in learning and memory. Science. 2001;294:1048–52.

    Article  CAS  PubMed  Google Scholar 

  16. Maquet P, Schwartz S, Passingham R, et al. Sleep-related consolidation of a visuo-motor skill: brain mechanisms as assessed by fMRI. J Neurosci. 2003;23:1432–40.

    CAS  PubMed  Google Scholar 

  17. Mazzoni G, Gori S, Formicola G, et al. Word recall correlates with sleep cycles in elderly subjects. J Sleep Res. 1999;8(3):185–8.

    Article  CAS  PubMed  Google Scholar 

  18. Walker MP. The role of sleep in cognition and emotion. Ann N Y Acad Sci. 2009;1156:168–97.

    Article  PubMed  Google Scholar 

  19. Empson J, Clarke P. Rapid eye movements and remembering. Nature. 1970;227:287–8.

    Article  CAS  PubMed  Google Scholar 

  20. Kales A, Hoedemaker F, Jacobson A et al. Dream Deprivation: an Experimental Reappraisal. Nature 1964;204:1337–8.

    Article  CAS  PubMed  Google Scholar 

  21. Goel N, Rao H, Durmer JS, et al. Neurocognitive consequences of sleep deprivation. Semin Neurol. 2009;29(4):320–39.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Blackwell T, Yaffe K, Ancoli-Israel S, et al. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci 2006;61(4):405–10.

    Article  PubMed  Google Scholar 

  23. Blackwell T, Yaffe K, Ancoli-Israel S, et al. Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study. Sleep. 2011;34(10):1347–56.

    PubMed Central  PubMed  Google Scholar 

  24. Cole CS, Richards KC, Beck CC, et al. Relationship among disordered sleep and cognitive and functional status in nursing home residents. Res Gerontol Nurs. 2009;2(3):183–191.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Kronholm E, Sallinen M, Suutama T, et al. Self-reported sleep duration and cognitive functioning in the general population. J Sleep Res. 2009;18(4):436–46.

    Article  PubMed  Google Scholar 

  26. Bonnet, MH Cognitive effects of sleep and sleep fragmentation. Sleep 1993 16 Suppl 8:S65–67.

    CAS  PubMed  Google Scholar 

  27. Bastien CH, Fortier-Brochu E, Rioux I, et al. Cognitive performance and sleep quality in the elderly suffering from chronic insomnia. Relationship between objective and subjective measures. J Psychosom Res. 2003;54(1):39–49.

    Article  PubMed  Google Scholar 

  28. Nebes RD, Buysse DJ, Halligan EM, et al. Self-reported sleep quality predicts poor cognitive performance in healthy older adults. J Gerontol B Psychol Sci Soc Sci. 2009;64(2):180–7.

    Article  PubMed  Google Scholar 

  29. Jelicic M, Bosma H, Ponds RW, et al. Subjective sleep problems in later life as predictors of cognitive decline. Report from the Maastricht Ageing Study (MAAS). Int J Geriatr Psychiatry. 2002;17(1):73–7.

    Article  PubMed  Google Scholar 

  30. Schmutte T, Harris S, Levin R, et al. The relation between cognitive functioning and self-reported sleep complaints in nondemented older adults: results from the Bronx aging study. Behav Sleep Med.2007;5(1):39–56.

    Article  PubMed  Google Scholar 

  31. Morris GO, Williams HL, Lubin A. Misperception and disorientation during sleep. Arch Gen Psychiatry. 1960;2:247–54.

    Article  Google Scholar 

  32. Cantero JL, Atienza M, Salas RM, et al. Effects of prolonged waking-auditory stimulation on electroencephalogram synchronization and cortical coherence during subsequent slow-wave sleep. J Neurosci. 2002;22(11):4702–8.

    CAS  PubMed  Google Scholar 

  33. Landsness EC, Crupi D, Hulse BK, et al. Sleep-dependent improvement in visuomotor learning: a causal role for slow waves. Sleep. 2009;32(10):1273–84.

    PubMed Central  PubMed  Google Scholar 

  34. Malhotra RK, Desai AK. Healthy brain aging: what has sleep got to do with it? Clin Geriatr Med. 2010;26(1):45–56

    Article  PubMed  Google Scholar 

  35. Marshall L, Born J. The contribution of sleep to hippocampus-dependent memory consolidation. Trends Cogn Sci. 2007;11(10):442–50.

    Article  PubMed  Google Scholar 

  36. Mölle M, Marshall L, Gais S, et al. Learning increases human electroencephalographic coherence during subsequent slow sleep oscillations. Proc Natl Acad Sci U S A. 2004;101(38):13963–8.

    Article  PubMed Central  PubMed  Google Scholar 

  37. Krueger JM, Clinton JM, Winters BD, et al. Involvement of cytokines in slow wave sleep. Prog Brain Res. 2011;193:39–47.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Ellenbogen JM, Hulbert JC, Stickgold R, et al. Interfering the theories of sleep and memory: sleep, declarative memory, and associative interference. Curr Biol. 2006;16:1290–4.

    Article  CAS  PubMed  Google Scholar 

  39. Peigneux P, Laureys S, Fuchs S, et al. Are spatial memories strengthened in the human hippocampus during slow wave sleep? Neuron. 2004;44:535–45.

    Article  CAS  PubMed  Google Scholar 

  40. Wilson MA, McNaughton BL. Reactivation of hippocampal ensemble memories during sleep. Science. 1994;265:676–9.

    Article  CAS  PubMed  Google Scholar 

  41. Wagner U, Gais S, Haider H, et al. Sleep inspires insight. Nature. 2004;427:352–5.

    Article  CAS  PubMed  Google Scholar 

  42. Buzsaki G. The hippocampo-neocortical dialogue. Cereb Cortex. 1996;6:81–92.

    Article  CAS  PubMed  Google Scholar 

  43. Gais S, Albouy G, Boly M, et al. Sleep transforms the cerebral trace of declarative memories. Proc Natl Acad Sci U S A. 2007;104:18778–83.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Graves L, Pack A, Abel T. Sleep and memory: a molecular perspective. Trends Neurosci. 2001;24(4):237–43.

    Article  CAS  PubMed  Google Scholar 

  45. Perry E, Walker M, Grace J, et al. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci. 1999;22:273–80.

    Article  CAS  PubMed  Google Scholar 

  46. Huber R, Ghilardi MF, Massimini M, et al. Local sleep and learning. Nature. 2004;430:78–81.

    Article  CAS  PubMed  Google Scholar 

  47. Fosse MJ, Fosse R, Hobson JA, et al. Dreaming and episodic memory: a functional dissociation? J Cogn Neurosci. 2003;15:1–9.

    Article  PubMed  Google Scholar 

  48. Drago V, Foster PS, Heilman KM, Aricò D, Williamson J, Montagna P, Ferri R. Cyclic alternating pattern in sleep and its relationship to creativity. Sleep Med. 2011;12(4):361–6.

    Article  PubMed  Google Scholar 

  49. Bliwise D. Sleep in normal aging and dementia. Sleep 1993 16(1):40–81.

    CAS  PubMed  Google Scholar 

  50. Hot P, Rauchs G, Bertran F, et al. Changes in sleep theta rhythm are related to episodic memory impairment in early Alzheimer’s disease. Biol Psychol. 2011;87(3):334–9.

    Article  PubMed  Google Scholar 

  51. Prinz P, Vitiello M, Murray R, et al. Sleep disorders and aging N Engl J Med 1990;323:520–6.

    Article  CAS  PubMed  Google Scholar 

  52. Chokroverty S. Sleep and neurodegenerative diseases. Semin Neurol. 2009;29(4):446–67.

    Article  PubMed  Google Scholar 

  53. Guarnieri B, Adorni F, Musicco M, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord. 2012;33(1):50–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  54. Ahlskog JE. Parkinson’s disease: is the initial treatment established? Curr Neurol Neurosci Rep. 2003;3(4):289–95.

    Article  PubMed  Google Scholar 

  55. Moe KE, Vitiello MV, Larsen LH, et al. Symposium: cognitive processes and sleep disturbances: sleep/wake patterns in Alzheimer’s disease: relationships with cognition and function. J Sleep Res. 1995;4(1):15–20.

    Article  PubMed  Google Scholar 

  56. Deschenes CL, McCurry SM. Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep. 2009;11(1):20–6.

    Article  PubMed Central  PubMed  Google Scholar 

  57. Craig D, Hart DJ, Passmore AP. Genetically increased risk of sleep disruption in Alzheimer’s disease. Sleep. 2006;29(8):1003–7.

    PubMed  Google Scholar 

  58. Wu YH, Fischer DF, Swaab DF. A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimer’s disease patients. Brain Res. 2007;1167:13–9.

    Article  CAS  PubMed  Google Scholar 

  59. Ancoli-Israel S, Klauber MR, Butters N, et al. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 1991;39:258–63.

    Article  CAS  PubMed  Google Scholar 

  60. Ancoli-Israel S, Palmer BW, Cooke JR, et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc. 2008;56(11):2076–81.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Cooke JR, Ayalon L, Palmer BW, et al. Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer’s disease and obstructive sleep apnea: a preliminary study. J Clin Sleep Med. 2009;5(4):305–9.

    PubMed Central  PubMed  Google Scholar 

  62. Aloia MS, Arnedt JT, Davis JD et al. Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychol Soc. 2004;10(5):772–85.

    PubMed  Google Scholar 

  63. Antic NA, Catcheside P, Buchan C, et al. The effect of CPAP in normalizing day-time sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA. Sleep. 2011;34;111–9.

    Article  PubMed Central  PubMed  Google Scholar 

  64. Sforza E, Roche F. Sleep apnea syndrome and cognition. Front Neurol. 2012;3:87 (Epub 2012).

    PubMed Central  PubMed  Google Scholar 

  65. Rose KM, Beck C, Tsai PF, et al. Sleep disturbances and nocturnal agitation behaviors in older adults with dementia. Sleep. 2011;34(6):779–86.

    Article  PubMed Central  PubMed  Google Scholar 

  66. Aurora RN, Kristo DA, Bista SR, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American academy of sleep medicine clinical practice guideline. Sleep. 2012;35(8):1039–62.

    PubMed Central  PubMed  Google Scholar 

  67. Ferman TJ, Boeve BF. Dementia with Lewy bodies. Neurol Clin. 2007;25(3):741–60

    Article  PubMed Central  PubMed  Google Scholar 

  68. Ferman TJ, Boeve BF, Smith GE, et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. 2011;77(9):875–82.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  69. Fujishiro H, Iseki E, Murayama N, et al. Diffuse occipital hypometabolism on [18 F]-FDG PET scans inpatients with idiopathic REM sleep behavior disorder: prodromal dementia with Lewy bodies? Psychogeriatrics. 2010;10(3):144–52.

    Article  PubMed  Google Scholar 

  70. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863–72.

    Article  CAS  PubMed  Google Scholar 

  71. Bliwise DL, Mercaldo ND, Avidan AY, et al. Sleep disturbance in dementia with Lewy bodies and Alzheimer’s disease: a multicenter analysis. Dement Geriatr Cogn Disord. 2011;31(3):239–46.

    Article  PubMed Central  PubMed  Google Scholar 

  72. Boeve BF. Mild cognitive impairment associated with underlying Alzheimer’s disease versus Lewy body disease. Parkinsonism Relat Disord. 2012;18 Suppl 1:S41–4.

    Article  PubMed  Google Scholar 

  73. Boeve BF, Silber MH, Ferman TJ. Current management of sleep disturbances in dementia. Curr Neurol Neurosci Rep. 2002;2(2):169–77.

    Article  PubMed  Google Scholar 

  74. Gagnon RB, Vendette JF, Fantini M, et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology. 2009;72(15):1296–1300.

    Article  PubMed Central  PubMed  Google Scholar 

  75. McCarter SJ, St Louis EK, Boeve BF. REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. Curr Neurol Neurosci Rep. 2012;12(2):182–92.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  76. Pao WC, Boeve BF, Ferman TJ, et al. Polysomnographic findings in dementia with Lewy bodies. Neurologist. 2013;19(1):1–6.

    Article  PubMed Central  PubMed  Google Scholar 

  77. Baumann CR, Dauvilliers Y, Mignot E, et al. Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness. Eur Neurol. 2004;52(2):73–6.

    Article  CAS  PubMed  Google Scholar 

  78. Hibi S, Yamaguchi Y, Umeda-Kameyama Y, et al. The high frequency of periodic limb movements in patients with Lewy body dementia. J Psychiatr Res. 2012;46:1590–4.

    Google Scholar 

  79. Claassen DO, Josephs KA, Ahlskog JE, et al. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010;75(6):494–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  80. Postuma RB, Lang AE, Gagnon JF, et al. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain. 2012;135(Pt 6):1860–70.

    Article  CAS  PubMed  Google Scholar 

  81. Sixel-Doring F, Trautmann E, Mollenhauer B, et al. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology. 2011;77(11):1048–54.

    Article  PubMed  CAS  Google Scholar 

  82. Dauvilliers Y. Insomnia in patients with neurodegenerative conditions. Sleep Med. 2007;8 Suppl 4:S27–34.

    Article  PubMed  Google Scholar 

  83. Gjerstad MD, Wentzel-Larsen T, Aarsland D, et al. Insomnia in Parkinson’s disease: frequency and progression over time. J Neurol Neurosurg Psychiatry. 2007;78(5):476–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  84. Iranzo A, Comella CL, Santamaria J, et al. Restless legs syndrome in Parkinson’s disease and other neurodegenerative diseases of the central nervous system. Mov Disord. 2007;22 Suppl 18:S424–30.

    Article  PubMed  Google Scholar 

  85. Ondo WG, Dat Vuong K, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol. 2002;59:421–4.

    Article  PubMed  Google Scholar 

  86. Chotinaiwattarakul W, Dayalu P, Chervin RD, et al. Risk of sleep-disordered breathing in Parkinson’s disease. Sleep Breath. 2011;15(3):471–8.

    Article  PubMed Central  PubMed  Google Scholar 

  87. Cochen De Cock V, Abouda M, Leu S, et al. Is obstructive sleep apnea a problem in Parkinson’s disease? Sleep Med. 2010;11(3):247–52.

    Article  PubMed  Google Scholar 

  88. Trotti LM, Bliwise DL. No increased risk of obstructive sleep apnea in Parkinson’s disease. Mov Disord. 2010;25(13):2246–9.

    Article  PubMed Central  PubMed  Google Scholar 

  89. Yong MH, Fook-Chong S, Pavanni R, et al. Case control polysomnographic studies of sleep disorders in Parkinson’s disease. PLoS ONE. 2011;6(7):e22511.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  90. Zhou QP, Jung L, Richards KC. The management of sleep and circadian disturbance in patients with dementia. Curr Neurol Neurosci Rep. 2012;12(2):193–204.

    Article  PubMed  Google Scholar 

  91. Bliwise DL, Trotti LM, Wilson AG, et al. Daytime alertness in Parkinson’s disease: potentially dose-dependent, divergent effects by drug class. Mov Disord. 2012;27:1118–24.

    Google Scholar 

  92. Ferreira JJ, Galitzky M, Montastruc JL, et al. Sleep attacks and Parkinson’s disease treatment. Lancet. 2000;355(9212):1333–4.

    Article  CAS  PubMed  Google Scholar 

  93. Gottwald MD, Brainbridge JL, Dowling GA, et al. New pharmacotherapy for Parkinson’s disease. Ann Pharmacother. 1997;31:1205–17.

    CAS  PubMed  Google Scholar 

  94. Liu W, Miller BL, Kramer JH, et al. Behavioral disorders in the frontal and temporal variants of frontotemporal dementia. Neurology. 2004;62(5):742–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  95. Videnovic A, Leurgans S, Fan W, et al. Daytime somnolence and nocturnal sleep disturbances in Huntington disease. Parkinsonism Relat Disord. 2009;15(6):471–4.

    Article  PubMed  Google Scholar 

  96. Arnulf I, Nielsen J, Lohmann E, et al. Rapid eye movement sleep disturbances in Huntington disease. Arch Neurol. 2008;65(4):482–8.

    Article  PubMed  Google Scholar 

  97. Fish DR, Sawyers D, Allen PJ, et al. The effect of sleep on the dyskinetic movements of Parkinson’s disease, Gilles de la Tourette syndrome, Huntington’s disease, and torsion dystonia. Arch Neurol. 1991;48(2):210–4.

    Article  CAS  PubMed  Google Scholar 

  98. Goodman AO, Rogers L, Pilsworth S, et al. Asymptomatic sleep abnormalities are a common early feature in patients with Huntington’s disease. Curr Neurol Neurosci Rep. 2011;11(2):211–7.

    Article  PubMed  Google Scholar 

  99. Wiegand M, Möller AA, Lauer CJ, et al. Nocturnal sleep in Huntington’s disease. J Neurol. 1991;238(4):203–8.

    Article  CAS  PubMed  Google Scholar 

  100. Evers S, Stögbauer F. Genetic association of Huntington’s disease and restless legs syndrome? A family report. Mov Disord. 2003;18(2):225–7.

    Article  PubMed  Google Scholar 

  101. Savva E, Schnorf H, Burkhard PR. Restless legs syndrome: an early manifestation of Huntington’s disease? Acta Neurol Scand. 2009;119(4):274–6.

    Article  CAS  PubMed  Google Scholar 

  102. Boeve BF, Silber MH, Parisi JE, et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology. 2003;61(1):40–5.

    Article  CAS  PubMed  Google Scholar 

  103. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256:183–94

    Article  CAS  PubMed  Google Scholar 

  104. Ratcliff R, Van Dongen HP. Sleep deprivation affects multiple distinct cognitive processes. Psychon Bull Rev. 2009;16:742–51.

    Article  PubMed Central  PubMed  Google Scholar 

  105. Kim SJ, Lee JH, Lee DY, et al. Neurocognitive dysfunction associated with sleep quality and sleep apnea in patients with mild cognitive impairment. Am J Geriatr Psychiatry. 2011;19(4):374–81.

    Article  PubMed  Google Scholar 

  106. Molano J, Boeve B, Ferman T, et al. Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain. 2010;133(Pt 2):540–56.

    Article  PubMed Central  PubMed  Google Scholar 

  107. Naismith SL, Rogers NL, Hickie IB, et al. Sleep well, think well: sleep-wake disturbance in mild cognitive impairment. J Geriatr Psychiatry Neurol. 2010;23(2):123–30.

    Article  PubMed  Google Scholar 

  108. Devine ME, Fonseca JA, Walker Z. Do cerebral white matter lesions influence the rate of progression from mild cognitive impairment to dementia? Int Psychogeriatr. 2013;25:120–7.

    Google Scholar 

  109. Gottlieb DJ, DeStefano AL, Foley DJ, et al APOE e4 is associated with obstructive sleep apnea/hypopnea: the sleep heart health study. Neurology. 2004;63:664–8.

    Article  CAS  PubMed  Google Scholar 

  110. Hita-Yañez E, Atienza M, Gil-Neciga E, et al. Disturbed sleep patterns in elders with mild cognitive impairment: the role of memory decline and ApoE É4 genotype. Curr Alzheimer Res. 2012;9(3):290–7.

    Article  PubMed  Google Scholar 

  111. Desai AK, Schwartz L, Grossberg GT. Behavioral Disturbance in Dementia. Curr Psychiatry Rep. 2012;14:298–309.

    Google Scholar 

  112. Foley DJ, Monjan AA, Brown SL, et al. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995;18(6):425–32.

    CAS  PubMed  Google Scholar 

  113. Sullivan SC, Richards KC. Predictors of circadian sleep-wake rhythm maintenance in elders with dementia. Aging Ment Health. 2004;8(2):143–52.

    Article  CAS  PubMed  Google Scholar 

  114. de Jonghe A, Korevaar JC, van Munster BC, et al. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int J Geriatr Psychiatry. 2010;25:1201–8.

    Article  PubMed  Google Scholar 

  115. Gallagher-Thompson D, Brooks JO, et al. The relations among caregiver stress, “sundowning” symptoms, and cognitive decline in Alzheimer’s disease. J Am Geriatr Soc. 1992:40:807–10.

    Article  CAS  PubMed  Google Scholar 

  116. Lipowski ZJ. Delirium: acute brain failure in man. Springfield: Charles C. Thomas; 1980.

    Google Scholar 

  117. Cameron DE. Studies in senile nocturnal delirium. Psychiatr Q 1941;15:47–53.

    Article  Google Scholar 

  118. Bedrosian TA, Nelson RJ. Sundowning syndrome in aging and dementia: research in mouse models. Exp Neurol. 2013;243:67–73.

    Google Scholar 

  119. Bedrosian TA, Herring KL, Weil ZM, et al. Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proc Natl Acad Sci U S A. 2011;108(28):11686–91.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  120. McCurry SM, Reynolds CF, Ancoli-Israel S, et al. Treatment of sleep disturbance in Alzheimer’s disease. Sleep Med Rev. 2000;4(6):603–28.

    Article  PubMed  Google Scholar 

  121. Volicer L, Harper DG, Manning BC, et al. Sundowning and circadian rhythms in Alzheimer’s disease. Am J Psychiatry. 2001;158:704–11.

    Article  CAS  PubMed  Google Scholar 

  122. Khachiyants N, Trinkle D, Son SJ, et al. Sundown syndrome in persons with dementia: an update. Psychiatry Investig. 2011;8:275–87.

    Article  PubMed Central  PubMed  Google Scholar 

  123. Stopa EG, Volicer L, Kuo-Leblanc V, et al. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. J Neuropathol Exp Neurol. 1999;58(1):29–39.

    Article  CAS  PubMed  Google Scholar 

  124. Cardinali DP, Furio AM, Brusco LI. Clinical aspects of melatonin intervention in Alzheimer’s disease progression. Curr Neuropharmacol. 2010;8:218–27.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  125. Zhdanova IV, Tucci V. Melatonin, circadian rhythms, and sleep. Curr Treat Options Neurol. 2003;5(3):225–9.

    Article  PubMed  Google Scholar 

  126. Riemersma-van der Lek RF, Swaab DF, Twisk J, et al. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008;299(22):2642–55.

    Article  CAS  PubMed  Google Scholar 

  127. Dowling GA, Mastick J, Hubbard EM, et al. Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 2005;20(8):738–43.

    Article  PubMed Central  PubMed  Google Scholar 

  128. Dowling GA, Burr RL, Van Someren EJ, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr Soc. 2008;56(2):239–46.

    Article  PubMed Central  PubMed  Google Scholar 

  129. Forbes D, Morgan DG, Bangma J, et al. Light therapy for managing sleep, behaviour, and mood disturbances in dementia. Cochrane Database Syst Rev. 2004;(2):CD003946.

    Google Scholar 

  130. McCurry SM, Pike KC, Vitiello MV, et al. Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer’s disease: results of a randomized, controlled trial. J Am Geriatr Soc. 2011;59(8):1393–402.

    Article  PubMed Central  PubMed  Google Scholar 

  131. Most EI, Scheltens P, Van Someren EJ. Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light–a randomized clinical trial. Trials. 2010;11:19.

    Article  PubMed Central  PubMed  Google Scholar 

  132. Salami O, Lyketsos C, Rao V. Treatment of sleep disturbance in Alzheimer’s dementia. Int J Geriatr Psychiatry. 2011;26(8):771–82.

    Article  PubMed Central  PubMed  Google Scholar 

  133. Shirani A, St Louis EK. Illuminating rationale and uses for light therapy. J Clin Sleep Med. 2009;5(2):155–63.

    PubMed Central  PubMed  Google Scholar 

  134. Skjerve A, Holsten F, Aarsland D, et al. Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia. Psychiatry Clin Neurosci. 2004;58(4):343–7.

    Article  PubMed  Google Scholar 

  135. Sloane PD, Williams CS, Mitchell CM, et al. High-intensity environmental light in dementia: effect on sleep and activity. J Am Geriatr Soc. 2007;55(10):1524–33.

    Article  PubMed  Google Scholar 

  136. Gooley JJ. Treatment of circadian rhythm sleep disorders with light. Ann Acad Med Singapore. 2008;37(8):669–76.

    PubMed  Google Scholar 

  137. Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  138. Manford M, Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain. 1998;121(Pt 10):1819–40.

    Article  PubMed  Google Scholar 

  139. Manni R, Terzaghi M, Ratti PL, et al. Hallucinations and REM sleep behaviour disorder in Parkinson’s disease: dream imagery intrusions and other hypotheses. Conscious Cogn. 2011;20(4):1021–6.

    Article  PubMed  Google Scholar 

  140. Silber MH, Hansen MR, Girish M. Complex nocturnal visual hallucinations. Sleep Med. 2005;6(4):363–6.

    Article  PubMed  Google Scholar 

  141. American Academy of Sleep Medicine. International classification of sleep disorders, 2nd ed.: diagnostic and coding manual. Westchester, Illinois: American Academy of Sleep Medicine; 2005.

    Google Scholar 

  142. Patrick GT, Gilbert JA. On the effects of loss of sleep. Psychol Rev. 1896;3:469–83.

    Article  Google Scholar 

  143. Campbell IG, Guinan MJ, Horowitz JM. Sleep deprivation impairs long-term potentiation in rat hippocampal slices. J Neurophysiol. 2002;88:1073–76.

    CAS  PubMed  Google Scholar 

  144. Chee MW, Chuah YM. Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation. Proc Natl Acad Sci. 2007;104;9487–92.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  145. Davis CJ, Harding JW, Wright JW. REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus. Brain Res. 2003;973:293–7.

    Article  CAS  PubMed  Google Scholar 

  146. Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol. 2005;25(1):117–29.

    Article  PubMed  Google Scholar 

  147. Petersen RC. Clinical practice. Mild cognitive impairment. N Engl J Med. 2011;364(23):2227–34.

    Article  CAS  PubMed  Google Scholar 

  148. Thomas M, Sing H, Belenky G, et al. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res. 2000;9(4):335–52.

    Article  CAS  PubMed  Google Scholar 

  149. Raymann RJ, Swaab DF, Van Someren EJ. Skin temperature and sleep-onset latency: changes with age and insomnia. Physiol Behav. 2007;90(2–3):257–66.

    Article  CAS  PubMed  Google Scholar 

  150. Ohayon MM, Vecchierini MF. Normative sleep data, cognitive function and daily living activities in older adults in the community. Sleep. 2005;28(8):981–9.

    PubMed  Google Scholar 

  151. Kang JE, Lim MM, Bateman RJ, et al. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009;326(5955):1005–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  152. Yang RH, Hu SJ, Wang Y, et al. Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus. Brain Res. 2008;1230:224–32.

    Article  CAS  PubMed  Google Scholar 

  153. Drummond SP, Brown GG, Gillin JC, et al. Altered brain response to verbal learning following sleep deprivation. Nature. 2000 403:655–7.

    Article  CAS  PubMed  Google Scholar 

  154. Guzman-Marin R, Bashir T, Suntsova N, et al. Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat. Neuroscience. 2007;148(1):325–33.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  155. Meerlo P, Mistlberger RE, Jacobs BL, et al. New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Med Rev. 2009;13(3):187–94.

    Article  PubMed Central  PubMed  Google Scholar 

  156. Sportiche N, Suntsova N, Methippara M, et al. Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis. Neuroscience. 2010;170(1):247–58.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  157. García-García F, De la Herrán-Arita AK, Juárez-Aguilar E, et al. Growth hormone improves hippocampal adult cell survival and counteracts the inhibitory effect of prolonged sleep deprivation on cell proliferation. Brain Res Bull. 2011;84(3):252–7.

    Article  PubMed  CAS  Google Scholar 

  158. Mueller AD, Mear RJ, Mistlberger RE. Inhibition of hippocampal neurogenesis by sleep deprivation is independent of circadian disruption and melatonin suppression. Neuroscience. 2011;193:170–81.

    Article  CAS  PubMed  Google Scholar 

  159. Tranah GJ, Blackwell T, Stone KL, et al. Circadian activity rhythms and risk of incident dementia and MCI in older women. Ann Neurol. 2011;70(5):722–32.

    Article  PubMed Central  PubMed  Google Scholar 

  160. Antonelli Incalzi R, Marra C, Salvigni BL, et al. Does cognitive dysfunction conform to a distinctive pattern in obstructive sleep apnea syndrome? J Sleep Res. 2004;13(1):79–86.

    Article  PubMed  Google Scholar 

  161. Cohen-Zion M, Stepnowsky C, Marler M, et al. Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc. 2001;49(12):1622–7.

    Article  CAS  PubMed  Google Scholar 

  162. Kim HC, Young T, Matthews CG, et al. Sleep-disordered breathing and neuropsychological deficits: a population-based study. Am J Respir Crit Care Med. 1997;156:1813–9.

    Article  CAS  PubMed  Google Scholar 

  163. Sforza E, Roche F, Thomas-Anterion C, et al. Cognitive function and sleep related breathing disorders in a healthy elderly population: the SYNAPSE study. Sleep. 2010;33(4):515–21.

    PubMed Central  PubMed  Google Scholar 

  164. Weiss MD, Tamisier R, Boucher J, et al. Pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans. Sleep Med. 2009;10(7):739–45.

    Article  PubMed Central  PubMed  Google Scholar 

  165. Findley LJ, Barth JT, Powers DC, et al. Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest. 1986;90(5):686–90.

    Article  CAS  PubMed  Google Scholar 

  166. Yaffe K, Laffan AM, Harrison SL, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306(6):613–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  167. Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J. Sleep Res. 2002;11:1–16.

    Article  PubMed  Google Scholar 

  168. Canessa N, Castronovo V, Cappa, SF, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011;183:1419–26.

    Article  PubMed  Google Scholar 

  169. Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep. 2010;33(2):235–41.

    PubMed Central  PubMed  Google Scholar 

  170. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;166(10):1382–7.

    Article  PubMed  Google Scholar 

  171. Morrell MJ, Jackson ML, Twigg GL, et al. Changes in brain morphology in patients with obstructive sleep apnoea. Thorax. 2010;65(10):908–14.

    Article  CAS  PubMed  Google Scholar 

  172. Yaouhi K, Bertran F, Clochon P, et al. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res. 2009;18(1):36–48.

    Article  PubMed  Google Scholar 

  173. Macey PM;Kumar R;Woo MA;et al. Brain structural changes in obstructive sleep apnea. Sleep 2008;31(7):967–77

    PubMed Central  PubMed  Google Scholar 

  174. Krueger JM. The role of cytokines in sleep regulation. Curr Pharm Des. 2008:14:3408–16.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  175. Pickering M, Cumiskey D, O’Connor JJ Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system. Exp Physiol. 2005;90:663–70.

    Article  CAS  PubMed  Google Scholar 

  176. Ramesh V, Nair D, Zhang SX, et al. Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway. J Neuroinflammation. 2012;9:91.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  177. Elwood PC, Bayer AJ, Fish M, et al. Sleep disturbance and daytime sleepiness predict vascular dementia. J Epidemiol Community Health 2010;65(9):820–4

    Google Scholar 

  178. Jouvet M, Delorme F. Locus coeruleus et sommeil paradoxal. C R Soc Biol. 1965;159:895–9.

    Google Scholar 

  179. Schenck CH, Bundlie SR, Ettinger MG, et al. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep. 1986;9(2):293–308.

    CAS  PubMed  Google Scholar 

  180. Bonakis A, Howard RS, Ebrahim IO, et al. REM sleep behaviour disorder (RBD) and its associations in young patients. Sleep Med. 2009;10(6):641–5.

    Article  PubMed  Google Scholar 

  181. Iranzo A, Tolosa E, Gelpi E, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12(5):443–53.

    Article  PubMed  Google Scholar 

  182. Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744–8.

    Google Scholar 

  183. Frigerio R, Fujishiro H, Ahn TB, et al. Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging. 2011;32(5):857–63.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  184. Iranzo A, Lomeña F, Stockner H, et al. Decreased striatal dopamine zz as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurol. 2010;9(11):1070–7.

    Article  CAS  PubMed  Google Scholar 

  185. Kotagal V, Albin RL, Müller ML. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Ann Neurol. 2012;71(4):560–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  186. Fantini ML, Farini E, Ortelli P, et al. Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep. 2011;34(5):619–25.

    PubMed Central  PubMed  Google Scholar 

  187. Boot B, Boeve B, Roberts R, et al. Probable REM sleep behavior disorder increases risk for mild cognitive impairment and Parkinson’s disease: a population-based study. Ann Neurol. 2012;71(1):49–56.

    Article  PubMed Central  PubMed  Google Scholar 

  188. Adler CH, Hentz JG, Shill HA et al. Probable RBD is increased in Parkinson’s disease but not in essential tremor or restless legs syndrome. Parkinsonism Relat Disord. 2011;17(6):456–8.

    Article  PubMed Central  PubMed  Google Scholar 

  189. Postuma RB, Bertrand JA, Montplaisir J, et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: a prospective study. Mov Disord. 2012;27(6):720–6.

    Article  PubMed  Google Scholar 

  190. Postuma RB, Gagnon JF, Rompré S, et al. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology. 2010;74(3):239–44.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  191. Ratti PL, Terzaghi M, Minafra B, et al. REM and NREM sleep enactment behaviors in Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. Sleep Med. 2012;13(7):926–32.

    Article  PubMed  Google Scholar 

  192. McCarter SJ, Boswell CL, St Louis EK, et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med. 2013;14(3):237–42.

    Article  PubMed Central  PubMed  Google Scholar 

  193. Mahlberg R, Kunz D, Sutej I, et al. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J Clin Psychopharmacol. 2004;24(4):456–9.

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was supported by grants (P50 AG16574, U01 AG06786, RO1 AG32306, RO1 AG041797), the Mangurian Foundation, and by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number 1 UL1 RR024150–01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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McCarter, S., St. Louis, E., Boeve, B. (2015). Sleep, Cognitive Dysfunction, and Dementia. In: Chokroverty, S., Billiard, M. (eds) Sleep Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2089-1_33

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