Sleep Medicine pp 285-300 | Cite as

Sleep, Cognitive Dysfunction, and Dementia

  • Stuart J. McCarter
  • Erik K. St. Louis
  • Bradley F. BoeveEmail author


Sleep is vital to normal cognitive functioning, especially for the formation and consolidation of new memories. Altered circadian rhythm and sleep complaints are common in the aging population, especially in those with dementia, and sleep disturbances may further impact cognitive functioning in patients with dementia. Recent evidence also suggests that disturbed sleep and hypoxemia-related to sleep-disordered breathing may play a role in the development of dementia. Timely recognition and treatment of sleep disturbances may provide an avenue to improve memory and cognitive functioning and quality of life in patients with dementia.


RBD Dementia Memory consolidation ESS PET scan Synaptic homeostasis 



This work was supported by grants (P50 AG16574, U01 AG06786, RO1 AG32306, RO1 AG041797), the Mangurian Foundation, and by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number 1 UL1 RR024150–01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.


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Copyright information

© Springer Science+Business Media, LLC 2015

Authors and Affiliations

  • Stuart J. McCarter
    • 1
  • Erik K. St. Louis
    • 2
  • Bradley F. Boeve
    • 2
    Email author
  1. 1.Mayo Clinic and FoundationRochesterUSA
  2. 2.Mayo Center for Sleep Medicine, Department of NeurologyMayo Clinic and FoundationRochesterUSA

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