Sleep Medicine pp 223-228 | Cite as

Idiopathic Hypersomnia

  • Sona NevsimalovaEmail author


More than half a century ago, Prof. Roth recognized a leading symptom of idiopathic hypersomnia—sleep drunkenness—and described the first patients with prolonged nocturnal sleep accompanied by excessive daytime sleepiness with long unrefreshing naps and protracted and difficult awakening. The term idiopathic hypersomnia was given a variety of clinical labels including idiopathic central nervous hypersomnia or hypersomnolence, functional hypersomnia, mixed or harmonious hypersomnia, hypersomnia with automatic behavior, and nonrapid eye movement (REM) narcolepsy. Two different clinical forms recommended by Prof. Roth—polysymptomatic and monosymptomatic—disappeared for decades. Thanks to Prof. Billiard’s unflagging effort, two forms—idiopathic hypersomnia with long and without long sleep time—reappeared in the latest International Classification of Sleep Disorders, second edition (ICSD-2) classification. However, the biological background of these clinical entities remains unknown, and much effort is needed to shed more light on its pathophysiology.


Prof. Roth—idiopathic hypersomnia—monosymptomatic Polysymptomatic forms with long sleep Without long sleep 


  1. 1.
    Furukawa T. Heinrich Bruno Schindler’s description of narcolepsy in 1829. Neurology. 1987;37:146.CrossRefGoogle Scholar
  2. 2.
    Roth B. Sleep drunkenness and sleep paralysis [in Czech]. Ceskoslovenska Neurol. 1956;19:48–58.Google Scholar
  3. 3.
    Roth B. Narcolepsy and hypersomnia: from the aspect of sleep physiology [in Czech]. Praha: Stat. Zdrav. Naklad; 1957.Google Scholar
  4. 4.
    Aserinsky E, Kleitman N. Regularly occurring periods of eye motility and concomitant phenomena during sleep. Science. 1953;118:273–74.CrossRefPubMedGoogle Scholar
  5. 5.
    Aserinsky E, Kleitman N. Two types of ocular motility occurring in sleep. J Appl Physiol. 1955;8:1–10.PubMedGoogle Scholar
  6. 6.
    Dement WC, Kleitman N. Cyclic variation in EEG during sleep and their relation to eye movement, body motility, and dreaming. Electroencephalogr Clin Neurophysiol. 1957;9:673–90.CrossRefPubMedGoogle Scholar
  7. 7.
    Dement WC, Rechtschaffen A, Gulevich G. The nature of the narcoleptic sleep attack. Neurology. 1966;16:18–33.CrossRefPubMedGoogle Scholar
  8. 8.
    Rechtschaffen A, Roth B. Nocturnal sleep of hypersomniacs. Activ Nerv Sup.1969;11:229–33.Google Scholar
  9. 9.
    Roth B, Nevsimalova S, Rechtschaffen A. Hypersomnia with sleep drunkenness. Arch Gen Psych. 1972;26:456–62.CrossRefGoogle Scholar
  10. 10.
    Roth B., Bruhova S, Lehovsky M. REM sleep and NREM sleep in narcolepsy and hypersomnia. Electroenceph Clin Neurophysiol. 1969;26:176–82.Google Scholar
  11. 11.
    Roth B, Bruhova S. Dreams in narcolepsy, hypersomnia and dissociated sleep disorders. Exp Med Surg. 1969;27:187–209.Google Scholar
  12. 12.
    Bonkalo J. Hypersomnia. A discussion of psychiatric implications based on three cases. Brit J Psychiat. 1968;114:69–73.Google Scholar
  13. 13.
    Nevsimalova-Bruhova S, Roth B. Heredofamilial aspects of narcolepsy and hypersomnia. Schweiz Arch Neurol Psychiat. 1972;110:45–54.Google Scholar
  14. 14.
    Nevsimalova-Bruhova S. On the problem of heredity in hypersomnia, narcolepsy and dissociated sleep disturbances. Acta Univ Carol Med. 1973;18:109–60.Google Scholar
  15. 15.
    Roth B. Narcolepsy and hypersomnia. Review and classification of 642 personally observed patients. Schweiz Arch Neurol Neurochir Psychiat. 1976;119:31–41.Google Scholar
  16. 16.
    Association of Sleep Disorders Centers. Diagnostic classification of sleep and arousal disorders, first edition, prepared by the Sleep Disorders Classification Committee, HP. Roffwarg, Chairman. Sleep. 1979;2:1–137.Google Scholar
  17. 17.
    Roth B. Narcolepsy and hypersomnia. Basel: S. Karger; 1980.Google Scholar
  18. 18.
    Roth B, Nevsimalova S, Sagova V, Paroubkova D, Horakova A. Neurological, psychological and polygraphic findings in sleep drunkenness. Schweiz Arch Neurol Neurochir Psychiatr. 1981;129:209–22.Google Scholar
  19. 19.
    van den Hoed J, Kraemer H, Guilleminault C, Zarcone VP Jr., Miles LE, Dement WC et al. Disorders of excessive daytime somnolence: polygraphic and clinical data for 100 patients. Sleep. 1981;4:23–37.Google Scholar
  20. 20.
    Baker TL, Guilleminault C, Nino-Murcia G, Dement WC. Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia. Sleep. 1986;9:232–42.Google Scholar
  21. 21.
    Montplaisir J, Godbout R. Nocturnal sleep of narcoleptic patients: revisited. Sleep. 1986;9:159–61.Google Scholar
  22. 22.
    Poirier G, Montplaisir J, Decary F, Momege D, Lebrun A. HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. Sleep. 1986;9:153–8.Google Scholar
  23. 23.
    Honda Y, Juji T, Matsuki K, Naohara T, Satake M, Inko H et al. HLA-DR2 and Dw2 in narcolepsy and in other disorders of excessive somnolence without cataplexy. Sleep. 1986;9:133–42.Google Scholar
  24. 24.
    , Thorpy MJ (Chairman), Diagnostic Classification Steering Committee. International classification of sleep disorders: diagnostic and coding manual. Rochester: American Sleep Disorders Association; 1990.Google Scholar
  25. 25.
    Guilleminault C, Stoohs R, Clerk A, Cetel M, Maistros P. A cause of excessive daytime sleepiness. The upper airway resistance syndrome. Chest. 1993;104:781–7.Google Scholar
  26. 26.
    Aldrich MS. The clinical spectrum of narcolepsy and idiopathic hypersomnia. Neurology. 1996;46:393–401.Google Scholar
  27. 27.
    Bassetti C, Aldrich MS. Idiopathic hypersomnia. A series of 42 patients. Brain. 1997;120:1423–35.Google Scholar
  28. 28.
    Bruck D, Parkes JD. A comparison of idiopathic hypersomnia and narcolepsy-cataplexy using self report measures and sleep diary data. J Neurol Neurosurg Psychiat. 1996;60:576–8.Google Scholar
  29. 29.
    Billiard M. Idiopathic hypersomnia. Neurol Clin. 1996;14:573–2.Google Scholar
  30. 30.
    Billiard M, Dolenc L, Aldaz C, Ondze B, Besset A. Hypersomnia associated with mood disorders: a new perspective. J Psychosom Res. 1994;38 (Suppl.1):41–7.Google Scholar
  31. 31.
    Billiard M, Merle C, Carlander B, Ondze B, Alvarez D, Besset A. Idiopathic hypersomnia. Psychiatr Clin Neurosci. 1998;52:125–9.Google Scholar
  32. 32.
    Billiard M, Rondouin G, Espa F, Dauvilliers Y, Besset A. Physiopathologie de l´hypersomnie idiopathique. Données actuelles et nouvelles orientations. Rev Neurol (Paris). 2001;157:S101–6.Google Scholar
  33. 33.
    Billiard M. Diagnosis of narcolepsy and idiopathic hypersomnia. An update based on the International classification of sleep disorders. 2. Sleep Med Rev. 2007;11:378–88.Google Scholar
  34. 34.
    American Academy of Sleep Medicine. International classification of sleep disorders, 2nd ed.: Diagnostic and coding manual. Westchester, Illinois, American Academy of Sleep Medicine; 2005.Google Scholar
  35. 35.
    Vernet C, Arnulf I. Narcolepsy with long sleep time: a specific entity? Sleep. 2009;32:1229–35.Google Scholar
  36. 36.
    Vernet C, Arnulf I. Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients. Sleep. 2009;32:753–9.Google Scholar
  37. 37.
    Nevsimalova S., Blazejova K, Illnerova H, Hajek I, Vankova J, Pretl M. et al. A contribution to pathophysiology of idiopathic hypersomnia. In: Ambler Z, Nevsimalova S, Kadanka Z, Rossini PM, editors. Clinical neurophysiology at the beginning of the 21st century; Suppl Clin Neurophysiol. 2000;53:366–70.Google Scholar
  38. 38.
    Billiard M, Dauvilliers Y. Idiopathic hypersomnia. Sleep Med Rev. 2001;5:349–58.Google Scholar
  39. 39.
    Vernet C, Leu-Semenescu S, Buzare MA, Arnulf I. Subjective symptoms in idiopathic hypersomnia: beyond excessive sleepiness. J Sleep Res. 2010;19:525–34.Google Scholar
  40. 40.
    Sasai T, Inoue Y, Komada Y, Sugiura T, Matsushima E. Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1(*)1501/DQB1(*)0602 finding. Sleep Med. 2009;10:961–6.Google Scholar
  41. 41.
    Billiard M. From narcolepsy with cataplexy to idiopathic hypersomnia without long sleep time. Sleep Med. 2009;10:943–4.Google Scholar
  42. 42.
    Billiard M. Idiopathic hypersomnia. In: Thorpy MJ, Billiard M, eds. Sleepiness: causes, consequences and treatment. Cambridge: Cambridge University Press; 2011, pp.126–35.Google Scholar

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© Springer Science+Business Media, LLC 2015

Authors and Affiliations

  1. 1.Department of Neurology, 1st Faculty of MedicineCharles UniversityPrague 2Czech Republic

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