Abstract
Animal models are valuable and necessary for the purpose of better understanding the mechanisms underlying disease processes and for the development and evaluation of novel therapeutic approaches. Mouse models of receptor tyrosine kinases have been among the first to be developed and were not only indispensable for profoundly improving our understanding of diseases like cancer but also for the development of novel methodologies and techniques that impact also on the way how patients and human diseases are analyzed today. The quest of compiling an up-to-date survey of all mouse models of receptor tyrosine kinases is all but impossible, first because of the mere amount of mouse models that have been generated during the last 40 years and second due to the fact that the speed novel mouse models are generated with has dramatically increased during the last years and it is even difficult to assess the number of novel mouse models that have been developed during the process of writing this book.
Here we have tried to give a comprehensive overview about the mouse models of receptor tyrosine kinases. Although these molecules cannot be fully investigated without considering them in the context of their ligands for time and space reasons we had to focus on the receptor tyrosine kinases themselves.
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Holcmann, M. et al. (2015). Mouse Models of Receptor Tyrosine Kinases. In: Wheeler, D., Yarden, Y. (eds) Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2053-2_11
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