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Anti-HER2/neu Therapy in DCIS

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Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer

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Abstract

Ductal carcinoma in situ (DCIS) is a heterogeneous form of preinvasive breast cancer, with subtypes that are comparable to those of invasive disease. Targeted molecular therapies have improved outcomes for patients with invasive breast cancer, and we have parallel opportunities for advances in personalized treatment of DCIS. Early work has demonstrated synergy between human epidermal growth factor receptor (HER)2-targeted therapy and radiotherapy. Anti-HER2 therapy may also induce an immune response. This chapter addresses the history of research regarding HER2 expression in DCIS as well as ongoing clinical trials that address whether HER2-targeted therapy will improve patient outcomes in DCIS.

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Authors and Affiliations

  1. Division of Breast Surgical Oncology, Allegheny General Hospital, 320 East North Avenue, 15212, Pittsburgh, PA, USA

    Amelia Tower DO & Thomas B. Julian MD

  2. Robert H. Lurie Comprehensive Cancer Center, Chicago, USA

    Kalliopi P. Siziopikou MD, PhD

  3. Section of Medical Oncology, Department of Internal Medicine, Rush University Medical Center, 1725 West Harrison Street, Suite 809, 60612, Chicago, IL, USA

    Ruta D. Rao MD & Melody A. Cobleigh MD

  4. Breast Pathology Section, Department of Pathology, Northwestern University Feinberg School of Medicine, 251 East Huron Street, Feinberg 7, 60611, Chicago, IL, USA

    Kalliopi P. Siziopikou MD, PhD

  5. WPAHS Breast Surgical Oncology, Allegheny Health Network, Pittsburgh, USA

    Thomas B. Julian MD

  6. Temple University School of Medicine, Philadelphia, USA

    Thomas B. Julian MD

  7. Medical Affairs, National Surgical Adjuvant Breast and Bowel Project (NSABP), Pittsburgh, USA

    Thomas B. Julian MD

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  1. Amelia Tower DO
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Correspondence to Thomas B. Julian MD .

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  1. Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan, USA

    Lisa A. Newman

  2. Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan, USA

    Jessica M. Bensenhaver

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Tower, A., Rao, R., Siziopikou, K., Cobleigh, M., Julian, T. (2015). Anti-HER2/neu Therapy in DCIS. In: Newman, L., Bensenhaver, J. (eds) Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2035-8_10

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