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Smart Drug Delivery Systems

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Drug Delivery

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Abstract

In previous chapters, we identified the nature of the pharmacokinetic profile for a series of controlled-release systems. The zero-order release represented a simple, idealized, gradual release response, which allowed for a predicted dosage to be delivered over a predictable time regime. As we shifted our discussion to encapsulated and targeted systems, it became apparent that the zero-order release would be less relevant since the design strategy for these systems is to prevent interaction between the drug and physiological environment until the drug reaches the tissue target. Upon reaching the target, the system is either consumed or degraded in order to release the drug dosage form into the cellular environment. An important question that arises at this point in the discussion is

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  1. DuPont Central Research and Development, Wilmington, USA

    Eric P. Holowka

  2. School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA

    Sujata K. Bhatia

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Holowka, E.P., Bhatia, S.K. (2014). Smart Drug Delivery Systems. In: Drug Delivery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1998-7_7

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