Advertisement

Cytology of Endocervical Glandular Neoplasia

  • Rosemary H. Tambouret
  • David C. Wilbur
Chapter
Part of the Essentials in Cytopathology book series (EICP, volume 19)

Abstract

Accepted cytologic criteria for the diagnosis of adenocarcinoma in situ of the endocervix and variants are described and illustrated. The updated WHO histologic classification of endocervical adenocarcinoma is reviewed and the cytologic criteria for diagnosis are outlined. The cytologic features characteristic of “atypical glandular cells” are detailed. This category of cases includes cytologic presentations which are equivocal and therefore insufficient for an outright diagnosis of either adenocarcinoma in situ or invasive adenocarcinoma.

Keywords

Adenocarcinoma in situ Endocervix Endocervical adenocarcinoma Atypical glandular cells Cytology 

References

  1. 1.
    McCluggage WG. New developments in endocervical glandular lesions. Histopathology. 2013;62(1):138–60.CrossRefPubMedGoogle Scholar
  2. 2.
    Wells M, Ostor AG, Crum CP, Franceschi S, Tommasino M, Nesland JM, et al. Tumors of the uterine cervix: epithelial tumors. In: Tavassoli FA, Deville P, editors. Pathology and genetics of tumors of the breast and female genital organs. Lyon: IARC; 2003. p. 262–79.Google Scholar
  3. 3.
    Kurman RJ, Carcangiu M-L, Herrington CS, Young RH. WHO classification of tumours of female reproductive organs. Lyon: IARC; 2014.Google Scholar
  4. 4.
    Young RH, Clement PB. Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis. Histopathology. 2002;41(3):185–207.CrossRefPubMedGoogle Scholar
  5. 5.
    Krumins I, Young Q, Pacey F, Bousfield L, Mulhearn L. The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri. Acta Cytol. 1977;21(2):320–9.PubMedGoogle Scholar
  6. 6.
    Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998;18(1):38–43.CrossRefPubMedGoogle Scholar
  7. 7.
    Hemminki A. The molecular basis and clinical aspects of Peutz-Jeghers syndrome. Cell Mol Life Sci. 1999;55(5):735–50.CrossRefPubMedGoogle Scholar
  8. 8.
    Mikami Y, McCluggage WG. Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions. Adv Anat Pathol. 2013;20(4):227–37.CrossRefPubMedGoogle Scholar
  9. 9.
    Silverberg SG, Hurt WG. Minimal deviation adenocarcinoma (“adenoma malignum”) of the cervix: a reappraisal. Am J Obstet Gynecol. 1975;121(7):971–5.PubMedGoogle Scholar
  10. 10.
    Granter SR, Lee KR. Cytologic findings in minimal deviation adenocarcinoma (adenoma malignum) of the cervix. A report of seven cases. Am J Clin Pathol. 1996;105(3):327–33.PubMedGoogle Scholar
  11. 11.
    Szyfelbein WM, Young RH, Scully RE. Adenoma malignum of the cervix. Cytologic findings. Acta Cytol. 1984;28(6):691–8.PubMedGoogle Scholar
  12. 12.
    Ishii K, Katsuyama T, Ota H, Watanabe T, Matsuyama I, Tsuchiya S, et al. Cytologic and cytochemical features of adenoma malignum of the uterine cervix. Cancer. 1999;87(5):245–53.CrossRefPubMedGoogle Scholar
  13. 13.
    Hata S, Mikami Y, Manabe T. Diagnostic significance of endocervical glandular cells with “golden-yellow” mucin on pap smear. Diagn Cytopathol. 2002;27(2):80–4.CrossRefPubMedGoogle Scholar
  14. 14.
    Zaino RJ. The fruits of our labors: distinguishing endometrial from endocervical adenocarcinoma. Int J Gynecol Pathol. 2002;21(1):1–3.CrossRefPubMedGoogle Scholar
  15. 15.
    Schorge JO, Lee KR, Lee SJ, Flynn CE, Goodman A, Sheets EE. Early cervical adenocarcinoma: selection criteria for radical surgery. Obstet Gynecol. 1999;94(3):386–90.CrossRefPubMedGoogle Scholar
  16. 16.
    Lee KR, Minter LJ, Granter SR. Papanicolaou smear sensitivity for adenocarcinoma in situ of the cervix. A study of 34 cases. Am J Clin Pathol. 1997;107(1):30–5.PubMedGoogle Scholar
  17. 17.
    Lee KR, Genest DR, Minter LJ, Granter SR, Cibas ES. Adenocarcinoma in situ in cervical smears with a small cell (endometrioid) pattern: distinction from cells directly sampled from the upper endocervical canal or lower segment of the endometrium. Am J Clin Pathol. 1998;109(6):738–42.PubMedGoogle Scholar
  18. 18.
    Denton KJ, Herbert A, Turnbull LS, Waddell C, Desai MS, Rana DN, et al. The revised BSCC terminology for abnormal cervical cytology. Cytopathology. 2008;19(3):137–57.CrossRefPubMedGoogle Scholar
  19. 19.
    Chhieng DC, Cangiarella JF. Atypical glandular cells. Clin Lab Med. 2003;23(3):633–57.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Rosemary H. Tambouret
    • 1
  • David C. Wilbur
    • 1
  1. 1.Department of PathologyMassachusetts General HospitalBostonUSA

Personalised recommendations