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Chemotherapy for Gynecologic Cancer

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Gynecologic Oncology

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Abstract

Chemotherapy, either used alone or with surgery and/or radiation, plays an important role in the treatment of patients with gynecologic cancer. Common chemotherapy agents used in this group of patients are classified into groups based on pharmacological mechanisms. While many of them share the similar toxicities such as myelosuppression, each agent has its own toxicity profiles. It is often challenging for new providers to understand how these agents are used in different chemotherapy regimens and how to monitor and manage associated toxicities.

This chapter is divided into three sections:

  • The first part discusses the mechanisms, toxicities, and clinical pearls of common chemotherapy agents used in gynecologic oncology. Authors also share clinical pearls of each agent including administration, drug interactions, dosing adjustment, and other tips.

  • The second part of this chapter lists evidence-based chemotherapy regimens to treat common gynecologic cancers including cervical cancer, endometrial cancer, uterine sarcoma, and ovarian cancer based on stage. All references for these regimens are included at the end of the chapter to help providers find the original literature/clinical trial.

  • The third part of this chapter discusses common chemotherapy associated toxicities across various agents. Topics cover chemotherapy-induced nausea/vomiting (CINV), chemotherapy-induced diarrhea, peripheral neuropathy (CIPN), febrile neutropenia (FN), extravasation, and hypersensitivity (HSRs). The authors summarize the background, diagnosis, and evidence-based management approaches for each toxicity.

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  1. Dept. of Obstetrics and Gynecology Building 56, Suite 260, University of Calfornia, Irvine Irvine Medical Center, Orange, California, USA

    Ramez N. Eskander

  2. Dept. of Obstetrics and Gynecology Building 56, Room 260, University of California, Irvine Irvine Medical Center, Orange, California, USA

    Robert E. Bristow

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© 2015 Springer Science+Business Media New York

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Li, Q., Watkins, J.L. (2015). Chemotherapy for Gynecologic Cancer. In: Eskander, R., Bristow, R. (eds) Gynecologic Oncology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1976-5_6

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  • DOI: https://doi.org/10.1007/978-1-4939-1976-5_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1975-8

  • Online ISBN: 978-1-4939-1976-5

  • eBook Packages: MedicineMedicine (R0)

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