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Analysis and Modeling of Coordinated Multi-neuronal Activity pp 3–39Cite as

Techniques for Large-Scale Multiunit Recording

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Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 12))

Abstract

Single and multineuron extracellular electrophysiology has proven to be one of the most effective techniques to explore the behavior of neurons in freely behaving animals since the 1950s. Electrode technology has evolved over the past 60+ years, with improvements in electrode profiles, configurations, biocompatibility, and driving mechanisms leading to substantial gains in the isolation of single neuron activity and increases in the possible number of simultaneously recorded neurons. Moreover, combining electrode recording and nanotechnology with pharmacological and optogenetic manipulations are expected to bring about a new age for precise recording and manipulation of neurons. In this chapter we review the technical developments of extracellular electrophysiology in freely behaving animals, with special emphasis on the development of microelectrode technology.

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Acknowledgments

Special thanks to Mary Steenland, Sara-Lynn Pelegrin, Erik Hopkins, and Dr. Masami Tatsuno for a careful editing of this chapter.

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  1. Department of Neuroscience, University of Lethbridge, 440l University Drive W, Lethbridge, AB, TlK 3M4, Canada

    Hendrik W. Steenland Ph.D. & Bruce L. McNaughton Ph.D.

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Correspondence to Bruce L. McNaughton Ph.D. .

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  1. The University of Lethbridge, Lethbridge, Alberta, Canada

    Masami Tatsuno

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Steenland, H.W., McNaughton, B.L. (2015). Techniques for Large-Scale Multiunit Recording. In: Tatsuno, M. (eds) Analysis and Modeling of Coordinated Multi-neuronal Activity. Springer Series in Computational Neuroscience, vol 12. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1969-7_1

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