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Studies on the Cornea and Lens pp 275–285Cite as

p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation

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Abstract

The tumor suppressor p53 is a master regulator of apoptosis and also plays a key role in cell cycle progress and cell differentiation. It mainly acts as a transcription factor. In addition, it can also directly interact with apoptosis regulators in mitochondria to control apoptosis. Recent studies from our laboratory and others have shown that p53 plays an active role in regulating lens differentiation. It does so by modulating developmental apoptosis and also controlling expression of lens differentiation-specific genes. In this chapter, we summary the current progresses in this field.

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Acknowledgements

This work was supported in part by the National Institutes of Health grants, the National Natural Science Foundation of China (81272228), the collaborative grant from Zhongshan Ophthalmic Center (8282012-XCT, FYL, ZWL, YZL, and DWL), the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486) and the Chinese Scholarship Council (WKJ, XHH, WFH).

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, #54 Xianlie Road, Guangzhou, Guangdong, 510060, China

    Xiang-Cheng Tang, Fang-Yuan Liu, Zhong-Wen Luo, Yi-Zhi Liu & David Wan-Cheng Li

  2. Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5540, USA

    Xiang-Cheng Tang, Weike Ji, Xiao-Hui Hu, Wen-Feng Hu, Zhao-Xia Huang, Zhengfeng Wang, Zachary Woodward, Quan Dong Nguyen & David Wan-Cheng Li

  3. Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China

    Xiao-Hui Hu, Wen-Feng Hu, Zhao-Xia Huang & David Wan-Cheng Li

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  1. Xiang-Cheng Tang
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Correspondence to David Wan-Cheng Li .

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Editors and Affiliations

  1. Innovative Vision Products Inc., Moscow, Russia, Innovative Vision Products, Inc.,, County of New Castle, Delaware, USA

    Mark A. Babizhayev

  2. Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of Medicine, University of Nebraska Medical Center; Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China, Omaha, Nebraska, USA

    David Wan-Cheng Li

  3. Department of Pharmaceutical Sciences and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Anne Kasus-Jacobi

  4. Department of Ophthalmology, University of Pristina, Faculty of Medicine, Kosovska Mitrovica, Serbia

    Lepša Žorić

  5. Ophthalmology, Miguel Hernandez University, Alicante, Spain

    Jorge L. Alió

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Tang, XC. et al. (2015). p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation. In: Babizhayev, M., Li, DC., Kasus-Jacobi, A., Žorić, L., Alió, J. (eds) Studies on the Cornea and Lens. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1935-2_15

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