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Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis

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Studies on the Cornea and Lens

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Abstract

The protein serine/threonine phosphatases are major cellular phosphatases, responsible for 98 % dephosphorylation of proteins in eukaryotes. In the ocular lens, they are highly expressed and play important roles in both development and pathogenesis. In the present review, we have summarized these two aspects, which provide a basis for further studies on these important signaling molecules in the eye.

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Acknowledgments

This work was supported in part by the National Institutes of Health grants [EY015765 and EY018380], the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486), the National Natural Science Foundation of China (81272228), and the Lotus Scholar Program, and the Chinese Scholarship Council (WKJ, XHH, WFH).

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

    Wen-Feng Hu, Xiao-Hui Hu, Weike Ji, Zhao-Xia Huang, Ling Wang, Zachary Woodward, Quan Dong Nguyen & David Wan-Cheng Li

  2. Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China

    Wen-Feng Hu, Xiao-Hui Hu, Zhao-Xia Huang, Ling Wang & David Wan-Cheng Li

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  1. Wen-Feng Hu
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  2. Xiao-Hui Hu
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Correspondence to David Wan-Cheng Li .

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Editors and Affiliations

  1. Innovative Vision Products Inc., Moscow, Russia, Innovative Vision Products, Inc.,, County of New Castle, Delaware, USA

    Mark A. Babizhayev

  2. Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of Medicine, University of Nebraska Medical Center; Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China, Omaha, Nebraska, USA

    David Wan-Cheng Li

  3. Department of Pharmaceutical Sciences and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Anne Kasus-Jacobi

  4. Department of Ophthalmology, University of Pristina, Faculty of Medicine, Kosovska Mitrovica, Serbia

    Lepša Žorić

  5. Ophthalmology, Miguel Hernandez University, Alicante, Spain

    Jorge L. Alió

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Hu, WF. et al. (2015). Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis. In: Babizhayev, M., Li, DC., Kasus-Jacobi, A., Žorić, L., Alió, J. (eds) Studies on the Cornea and Lens. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1935-2_12

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