Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis

  • Wen-Feng Hu
  • Xiao-Hui Hu
  • Weike Ji
  • Zhao-Xia Huang
  • Ling Wang
  • Zachary Woodward
  • Quan Dong Nguyen
  • David Wan-Cheng LiEmail author
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


The protein serine/threonine phosphatases are major cellular phosphatases, responsible for 98 % dephosphorylation of proteins in eukaryotes. In the ocular lens, they are highly expressed and play important roles in both development and pathogenesis. In the present review, we have summarized these two aspects, which provide a basis for further studies on these important signaling molecules in the eye.


Phosphatases Dephosphorylation Lens Apoptosis Cell differentiation 



This work was supported in part by the National Institutes of Health grants [EY015765 and EY018380], the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486), the National Natural Science Foundation of China (81272228), and the Lotus Scholar Program, and the Chinese Scholarship Council (WKJ, XHH, WFH).


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Wen-Feng Hu
    • 1
    • 2
  • Xiao-Hui Hu
    • 1
    • 2
  • Weike Ji
    • 1
  • Zhao-Xia Huang
    • 1
    • 2
  • Ling Wang
    • 1
    • 2
  • Zachary Woodward
    • 1
  • Quan Dong Nguyen
    • 1
  • David Wan-Cheng Li
    • 1
    • 2
    Email author
  1. 1.Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of MedicineUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life SciencesHunan Normal UniversityChangshaChina

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