Clinical Scenario: The Role of Perioperative Chemotherapy

A 61-year-old man received neoadjuvant chemotherapy and radical cystectomy, with final pathology showing pT3aN0M0 disease
  • Eila C. SkinnerEmail author


Neoadjuvant chemotherapy plus radical cystectomy is the primary recommended therapy for muscle-invasive bladder cancer. Final surgical pathology is the strongest predictor of subsequent recurrence risk. There is no proven adjuvant treatment that can impact the risk of recurrence for those with adverse pathologic features such as persistent extravesical disease. These patients should be considered for clinical trials when available.


Neoadjuvant chemotherapy Predictors of recurrence Pathology Adjuvant therapy 



Cisplatin, methotrexate, vinblastine


Gemcitabine, cisplatin


Methotrexate, vinblastine, adriamycin (doxorubicin), cisplatin


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of UrologyThomas A. Stamey Research Chair of UrologyStanfordUSA

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