Clinical Scenario: Large Volume, Non-metastatic T2 Bladder Tumor

72-year-old man with a bulky, although mobile T2 urothelial carcinoma without evidence of metastasis
  • Chad R. RitchEmail author
  • Michael S. Cookson


The optimal treatment of bulky, non-metastatic, and locally advanced muscle-invasive bladder cancer (MIBC) involves a combination of chemotherapy and radical cystectomy. Evidence exists to support the use of neoadjuvant chemotherapy in the treatment of MIBC; however, there are a number of scenarios where this approach is not feasible or may not be practical. The goal of this chapter is to describe our approach to the treatment of MIBC, in particular the timing and use of chemotherapy with radical cystectomy, and to provide a practical guide based on our clinical experience.


Muscle-invasive bladder cancer Neoadjuvant chemotherapy Adjuvant chemotherapy Radical cystectomy 



Adjuvant chemotherapy


Complete response


Eastern Cooperative Oncology Group


Gemcitabine cisplatin


Muscle-invasive bladder cancer


Methotrexate vinblastine, adriamycin, cisplatin


Neoadjuvant chemotherapy


Performance status


Radical cystectomy


Transurethral resection of the bladder


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Miller School of MedicineUniversity of MiamiMiamiUSA
  2. 2.University of Oklahoma Medical CenterOklahoma CityUSA

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