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Management of Bladder Cancer pp 223–238Cite as

Intravesical Therapy

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Abstract

Intravesical therapy is an essential component in the treatment and prevention of non-muscle invasive bladder cancer. The bladder has specific properties which are amenable to local drug administration, enabling therapeutic effect while minimizing systemic exposure. The two primary forms of intravesical therapy are chemotherapy and immunotherapy. Chemotherapy can be administered perioperatively, in the adjuvant setting, and with maintenance, reducing recurrence rates. Immunotherapy primarily relies upon BCG, which reduces recurrence rates as well as progression, though with a possible increased side effect profile. Optimizing efficacy and enhancing drug delivery are current foci of active research, employing assistive technologies, new drug formulations, and host factors involved in the immune response. This chapter provides an overview of risks, benefits, and indications for existing intravesical agents.

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Disclosures

Funding sources:

Dr. McKiernan: Celgene, Prostate Cancer Foundation.

Dr. Ahn: none.

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Authors and Affiliations

  1. Department of Urology, New York-Presbyterian Hospital, Columbia University, New York, NY, USA

    Jennifer J. Ahn M.D.

  2. Department of Urology, Columbia University Medical Center, Herbert Irving Pavilion, 11th Floor, 161 Fort Washington Avenue, New York, NY, 10032, USA

    Jennifer J. Ahn M.D. & James M. McKiernan M.D.

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  1. Jennifer J. Ahn M.D.
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  2. James M. McKiernan M.D.
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Correspondence to James M. McKiernan M.D. .

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Editors and Affiliations

  1. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

    Badrinath R. Konety

  2. Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Sam S. Chang

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Dr. McKiernan: none.

Dr. Ahn: none.

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Ahn, J.J., McKiernan, J.M. (2015). Intravesical Therapy. In: Konety, B., Chang, S. (eds) Management of Bladder Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1881-2_18

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  • DOI: https://doi.org/10.1007/978-1-4939-1881-2_18

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  • Publisher Name: Springer, New York, NY

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  • Online ISBN: 978-1-4939-1881-2

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