Abstract
The embryologic development of the exocrine, endocrine, and ductal elements of the pancreas are detailed in this chapter. Emphasis is given to the different tumors in relation to their embryologic origin. Pancreatic pseudocysts are discussed in detail, correlating their development and presentation with the anatomical features of the lesser sac. The indications and key surgical maneuvers of pancreaticoduodenectomy are covered.
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References
Gittes GK. Developmental biology of the pancreas: a comprehensive review. Dev Biol. 2009;326:4–35.
Maker V, Gerzenshtein J, Lerner T. Annular pancreas in the adult: two case reports and review of more than a century of literature. Am Surg. 2003;69:404–10.
Klein SD, Affronti JP. Pancreas divisum, an evidence-based review: part I, pathophysiology. Gastrointest Endosc. 2004;60:419–25.
Klein SD, Affronti JP. Pancreas divisum, an evidence-based review: part II, patient selection and treatment. Gastrointest Endosc. 2004;60:585–9.
Baetens D, Malaisse-Lagae F, Perrelet A, Orci L. Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science. 1979;206:1323–5.
Bocian-Sobkowska J, Zabel M, Wozniak W, Surdyk-Zasada J. Polyhormonal aspect of the endocrine cells of the human fetal pancreas. Histochem Cell Biol. 1999;112:147–53.
Oliver-Krasinski JM, Stoffers DA. On the origin of the beta cell. Genes Dev. 2008;22:1998–2021.
Baetge EE. Production of beta-cells from human embryonic stem cells. Diabetes Obes Metab. 2008;10 Suppl 4:186–94.
Wolfe-Coote SA, Du Toit DF. Distribution of cell types of the islets of Langerhans throughout the pancreas of the Chacma baboon. Anat Rec. 1987;217:172–7.
Abood GJ, Go A, Malhotra D, Shoup M. The surgical and systemic management of neuroendocrine tumors of the pancreas. Surg Clin N Am. 2009;89:249–66, x.
Alexakis N, Neoptolemos JP. Pancreatic neuroendocrine tumours. Best Pract Res Clin Gastroenterol. 2008;22:183–205.
Abboud B, Boujaoude J. Occult sporadic insulinoma: localization and surgical strategy. World J Gastroenterol. 2008;14:657–65.
Stabile BE, Morrow DJ, Passaro Jr E. The gastrinoma triangle: operative implications. Am J Surg. 1984;147:25–31.
Ellison EC, Johnson JA. The Zollinger-Ellison syndrome: a comprehensive review of historical, scientific, and clinical considerations. Curr Probl Surg. 2009;46:13–106.
Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ. Pancreatic VIPomas: subject review and one institutional experience. J Gastrointest Surg. 2008;12:382–93.
Corbetta S, Peracchi M, Cappiello V, et al. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab. 2003;88:3117–20.
Skandalakis LJ, Rowe Jr JS, Gray SW, Skandalakis JE. Surgical embryology and anatomy of the pancreas. Surg Clin N Am. 1993;73:661–97.
Reichardt W, Cameron R. Anatomy of the pancreatic veins. A post mortem and clinical phlebographic investigation. Acta Radiol Diagn (Stockh). 1980;21:33–41.
Chong M, Freeny PC, Schmiedl UP. Pancreatic arterial anatomy: depiction with dual-phase helical CT. Radiology. 1998;208:537–42.
Nimura Y. Pancreatic surgery: cutting-edge developments and technology. Pancreas. 1998;16:227–32.
McClusky 3rd DA, Skandalakis LJ, Colborn GL, Skandalakis JE. Harbinger or hermit? Pancreatic anatomy and surgery through the ages–part 3. World J Surg. 2002;26:1512–24.
McClusky 3rd DA, Skandalakis LJ, Colborn GL, Skandalakis JE. Harbinger or hermit? Pancreatic anatomy and surgery through the ages–part 2. World J Surg. 2002;26:1370–81.
McClusky 3rd DA, Skandalakis LJ, Colborn GL, Skandalakis JE. Harbinger or hermit? Pancreatic anatomy and surgery through the ages–part 1. World J Surg. 2002;26:1175–85.
Murakami G, Hirata K, Takamuro T, Mukaiya M, Hata F, Kitagawa S. Vascular anatomy of the pancreaticoduodenal region: a review. J Hepatobiliary Pancreat Surg. 1999;6:55–68.
Aghdassi A, Mayerle J, Kraft M, Sielenkamper AW, Heidecke CD, Lerch MM. Diagnosis and treatment of pancreatic pseudocysts in chronic pancreatitis. Pancreas. 2008;36:105–12.
Habashi S, Draganov PV. Pancreatic pseudocyst. World J Gastroenterol. 2009;15:38–47.
Rios G, Conrad A, Cole D, et al. Trends in indications and outcomes in the Whipple procedure over a 40-year period. Am Surg. 1999;65:889–93.
Wente MN, Shrikhande SV, Muller MW, et al. Pancreaticojejunostomy versus pancreaticogastrostomy: systematic review and meta-analysis. Am J Surg. 2007;193:171–83.
Diener MK, Heukaufer C, Schwarzer G, et al. Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev. 2008;(2):CD006053.
Marczell AP, Stierer M. Partial pancreaticoduodenectomy (Whipple procedure) for pancreatic malignancy: occlusion of a non-anastomosed pancreatic stump with fibrin sealant. HPB Surg. 1992;5:251–9; discussion 259–60.
Mann O, Strate T, Schneider C, Yekebas EF, Izbicki JR. Surgery for advanced and metastatic pancreatic cancer–current state and perspectives. Anticancer Res. 2006;26:681–6.
Mazor-Aronovitch K, Landau H, Gillis D. Surgical versus non-surgical treatment of congenital hyperinsulinism. Pediatr Endocrinol Rev. 2009;6:424–30.
Lillemoe KD, Kaushal S, Cameron JL, Sohn TA, Pitt HA, Yeo CJ. Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg. 1999;229:693–8; discussion 698–700.
Kimura W, Moriya T, Ma J, et al. Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein. World J Gastroenterol. 2007;13:1493–9.
Behrman SW, Fowler ES. Pathophysiology of chronic pancreatitis. Surg Clin N Am. 2007;87:1309–24, vii.
Conwell DL, Banks PA. Chronic pancreatitis. Curr Opin Gastroenterol. 2008;24:586–90.
Kim DH, Pickhardt PJ. Radiologic assessment of acute and chronic pancreatitis. Surg Clin N Am. 2007;87:1341–58, viii.
Mihaljevic AL, Kleeff J, Friess H, Buchler MW, Beger HG. Surgical approaches to chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2008;22:167–81.
Lowenfels AB, Maisonneuve P, Cavallini G, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med. 1993;328:1433–7.
O’Neil SJ, Aranha GV. Lateral pancreaticojejunostomy for chronic pancreatitis. World J Surg. 2003;27:1196–202.
Han SL, Chen J, Zhou HZ, Lan SH, Zhang PC, Zhu GB. Indications and surgical treatment of chronic pancreatitis. Hepatobiliary Pancreat Dis Int. 2008;7:638–42.
Frey CF, Reber HA. Local resection of the head of the pancreas with pancreaticojejunostomy. J Gastrointest Surg. 2005;9:863–8.
Beger HG, Kunz R, Poch B. The Beger procedure–duodenum-preserving pancreatic head resection. J Gastrointest Surg. 2004;8:1090–7.
Haney JC, Pappas TN. Necrotizing pancreatitis: diagnosis and management. Surg Clin N Am. 2007;87:1431–46.
Mathew A, Biswas A, Meitz KP. Endoscopic necrosectomy as primary treatment for infected peripancreatic fluid collections (with video). Gastrointest Endosc. 2008;68:776–82.
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Maker, V.K., Guzman-Arrieta, E.D. (2015). Pancreas. In: Cognitive Pearls in General Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1850-8_18
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DOI: https://doi.org/10.1007/978-1-4939-1850-8_18
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