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Thrombophilia Testing in Splanchnic Vein Thrombosis

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Mesenteric Vascular Disease

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Abstract

Splanchnic vein thrombosis should be considered as a thrombotic entity unique from venous thrombosis involving the lower extremity veins or pulmonary emboli. This disease largely stems from organ pathology to injury within the splanchnic circulation. Clinical assessment should begin with a thorough evaluation to exclude such pathology. For approximately 20 % of individuals, a provoking risk factor will not be evident. For these individuals, thrombophilia testing for both inherited and acquired thrombotic variables is warranted. The timing of thrombophilia testing is also important to consider. Many clot-based thrombophilia assays will be influenced by the thrombotic process, anticoagulant therapy, or hepatic injury associated with the event. Delaying test acquisition until these variables are no longer present will maximize test performance and resource utilization. Although not specifically established by randomized controlled trials, the results of this testing can influence anticoagulant duration if a strong thrombophilia can be identified.

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Authors and Affiliations

  1. Department of Medicine, Division of Cardiovascular Diseases, Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA

    Robert D. McBane II MD & Waldemar E. Wysokinski MD

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  1. Robert D. McBane II MD
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  2. Waldemar E. Wysokinski MD
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Correspondence to Waldemar E. Wysokinski MD .

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Editors and Affiliations

  1. Division of Vascular and Endovascular Therapy, Mayo Clinic Gonda Vascular Center, Rochester, Minnesota, USA

    Gustavo S. Oderich

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McBane, R.D., Wysokinski, W.E. (2015). Thrombophilia Testing in Splanchnic Vein Thrombosis. In: Oderich, G. (eds) Mesenteric Vascular Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1847-8_23

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  • DOI: https://doi.org/10.1007/978-1-4939-1847-8_23

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