Skip to main content

Sleep and Chronic Pain

  • Chapter
  • First Online:

Abstract

Chronic pain can be unrelenting. Unlike acute pain for which therapies could provide relief, chronic pain can seldom be cured. Persistent pain often impairs functioning. It may be surprising but chronic pain patients’ quality of life has been found to be lower than those of patients with chronic illnesses (e.g., chronic obstructive pulmonary disease) or life-threatening diseases (e.g., HIV/AIDS). While some individuals manage to live fulfilling lives despite pain, others suffer both physically and mentally and go on to develop anxiety, depression, and even increased suicidal ideation and behavior. One plausible reason is that, to many chronic pain patients, pain is not the only source of distress and disability. Among the many other concomitant health and emotional problems, sleep (or the lack of it) is a particular area with which most chronic pain patients want help.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Becker N, Bondegaard TA, Olsen AK, et al. Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center. Pain. 1997;73:393–400.

    Article  CAS  PubMed  Google Scholar 

  2. Casarett D, Karlawish J, Sankar P, et al. Designing pain research from the patient’s perspective: what trial end points are important to patients with chronic pain? Pain Med. 2001;2:309–16.

    Article  CAS  PubMed  Google Scholar 

  3. Smith BH, Torrance N, Bennett MI, et al. Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain. 2007;23:143–9.

    Article  PubMed  Google Scholar 

  4. Smith MT, Carmody TP, Smith MS. Quality of well-being scale and chronic low back pain. J Clin Psychol Med S. 2000;7:175–84.

    Article  Google Scholar 

  5. Tang NKY, Crane C. Suicidality in chronic pain: a review of the prevalence, risk factors and psychological links. Psychol Med. 2006;36:575–86.

    Article  PubMed  Google Scholar 

  6. Turk DC, Dworkin RH, Revicki D, et al. Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with pain. Pain. 2008;137:276–85.

    Article  PubMed  Google Scholar 

  7. Morin C, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain. 1998;14:311–4.

    Article  CAS  PubMed  Google Scholar 

  8. Smith M, Perlis M, Smith M, et al. Sleep quality and presleep arousal in chronic pain. J Behav Med. 2000;23:1–13.

    Article  CAS  PubMed  Google Scholar 

  9. Tang NKY, Wright KJ, Salkovskis PM. Prevalence and correlates of clinical insomnia co-occurring with chronic low back pain. J Sleep Res. 2007;16:85–95.

    Article  PubMed  Google Scholar 

  10. Morin CM, Espie CA. Insomnia: a clinical guide to assessment and treatment. New York: Springer; 2004.

    Google Scholar 

  11. McCracken LM, Iverson GL. Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Res Manag. 2002;7:75–9.

    PubMed  Google Scholar 

  12. Theadom A, Cropley M, Humphrey K. Exploring the role of sleep and coping in quality of life in fibromyalgia. J Psychosom Res. 2007;62:145–51.

    Article  PubMed  Google Scholar 

  13. Dworkin RH, Turk DC, Farrar JT, et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005;113:9–19.

    Article  PubMed  Google Scholar 

  14. Turk DC, Dworkin RH, McDermott MP, et al. Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations. Pain. 2008;139:485–93.

    Article  PubMed  Google Scholar 

  15. Rechtschaffen A, Bergmann B, Everson C, et al. Sleep deprivation in the rat: X integration and discussion of the findings. Sleep. 1989;25:68–87.

    Google Scholar 

  16. Guzman-Marýn R, Suntsova N, Stewart D, et al. Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats. J Physiol. 2003;549:563–71.

    Article  CAS  Google Scholar 

  17. Schmidek W, Zachariassen K, Hammel H. Total calorimetric measurements in the rat: influences of the sleep-wakefulness cycle and of the environmental temperature. Brain Res. 1983;288:261–71.

    Article  CAS  PubMed  Google Scholar 

  18. Everson C, Laatsch C, Hogg N. Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol. 2005;288:R374–83.

    Article  CAS  PubMed  Google Scholar 

  19. Toth L. Sleep, sleep deprivation and infectious disease: studies in animals. Adv Neuroimmunol. 1995;5:79–92.

    Article  CAS  PubMed  Google Scholar 

  20. Everson C. Sustained sleep deprivation impairs host defense. Am J Physiol. 1993;265:R1148–54.

    CAS  PubMed  Google Scholar 

  21. Everson C. Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1054–63.

    Article  CAS  PubMed  Google Scholar 

  22. Ranjbaran Z, Keefer L, Stepanski E, et al. The relevance of sleep abnormalities to chronic inflammatory conditions. Inflamm Res. 2007;56:51–7.

    Article  CAS  PubMed  Google Scholar 

  23. Ohayon MM, Caulet M, Philip P, et al. How sleep and mental disorders are related to complaints of daytime sleepiness. Arch Intern Med. 1997;157:2645–52.

    Article  CAS  PubMed  Google Scholar 

  24. Becker PM, Brown WD, Jamieson AO. Impact of insomnia: assessment with the sickness impact profile. Sleep Res. 1991;20:206.

    Google Scholar 

  25. Breslau N, Roth T, Rosenthal L, et al. Daytime sleepiness: an epidemiological study of young adults. Am J Public Health. 1997;87:1649–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Chang PP, Ford DE, Mead LA, et al. Insomnia in young men and subsequent depression. The Johns Hopkins study. Am J Epidemiol. 1997;146:105–14.

    Article  CAS  PubMed  Google Scholar 

  27. Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA. 1989;262:1479–84.

    Article  CAS  PubMed  Google Scholar 

  28. Mellinger GD, Balter MB, Uhlenhuth EH. Insomnia and its treatment. Prevalence and correlates. Arch Gen Psychiatry. 1985;42:225–32.

    Article  CAS  PubMed  Google Scholar 

  29. Neckelmann D, Mykletun A, Dahl AA. Chronic insomnia as a risk factor for developing anxiety and depression. Sleep. 2007;30:873–80.

    PubMed Central  PubMed  Google Scholar 

  30. Simon GE, VonKorff M. Prevalence, burden, and treatment of insomnia in primary care. Am J Psychiatry. 1997;154:1417–23.

    CAS  PubMed  Google Scholar 

  31. Vollrath M, Wicki W, Angst J. The Zurich study. VIII. Insomnia: association with depression, anxiety, somatic syndromes, and course of insomnia. Eur Arch Psychiatry Neurol Sci. 1989;239:113–24.

    Article  CAS  PubMed  Google Scholar 

  32. Weissman MM, Greenwald S, Nino-Murcia G, et al. The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry. 1997;19:245–50.

    Article  CAS  PubMed  Google Scholar 

  33. Stickgold R, James L, Hobson J. Visual discrimination learning requires sleep after training. Nat Neurosci. 2000;3:1237–8.

    Article  CAS  PubMed  Google Scholar 

  34. Stickgold R, Whidbee D, Schirmer B, et al. Visual discrimination task improvement: a multi-step process occurring during sleep. J Cogn Neurosci. 2000;12:246–54.

    Article  CAS  PubMed  Google Scholar 

  35. McCarley R. Neurobiology of REM and NREM sleep. Sleep Med. 2007;8:302–30.

    Article  PubMed  Google Scholar 

  36. Ohayon MM. Relationship between chronic painful physical condition and insomnia. J Psychiatr Res. 2005;39:151–9.

    Article  PubMed  Google Scholar 

  37. Morphy H, Dunn KM, Lewis M, et al. Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30:274–80.

    PubMed  Google Scholar 

  38. Foley D, Ancoli-Israel S, Britz P, et al. Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey. J Psychosom Res. 2004;56:497–502.

    Article  PubMed  Google Scholar 

  39. Gabor JY, Cooper AB, Hanly PJ. Sleep disruption in the intensive care unit. Curr Opin Crit Care. 2001;7:21–7.

    Article  CAS  PubMed  Google Scholar 

  40. Redeker NS. Sleep in acute care settings: an integrative review. J Nurs Scholarsh. 2000;32:31–8.

    Article  CAS  PubMed  Google Scholar 

  41. Rosenberg-Adamsen S, Kehlet H, Dodds C, et al. Postoperative sleep disturbances: mechanisms and clinical implications. Br J Anaesth. 1996;76:552–9.

    Article  CAS  PubMed  Google Scholar 

  42. Redeker NS, Hedges C. Sleep during hospitalization and recovery after cardiac surgery. J Cardiovasc Nurs. 2002;17:56–68.

    Article  PubMed  Google Scholar 

  43. Raymond I, Nielsen TA, Lavigne G, et al. Quality of sleep and its daily relationship to pain intensity in hospitalized adult burn patients. Pain. 2001;92:381–8.

    Article  CAS  PubMed  Google Scholar 

  44. Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895–908.

    CAS  PubMed  Google Scholar 

  45. Dorrepaal KL, Aaronson NK, van Dam FS. Pain experience and pain management among hospitalized cancer patients. A clinical study. Cancer. 1989;63:593–8.

    Article  CAS  PubMed  Google Scholar 

  46. Atkinson JH, Ancoli-Israel S, Slater MA, et al. Subjective sleep disturbance in chronic back pain. Clin J Pain. 1988;4:225–32.

    Article  Google Scholar 

  47. Pilowsky I, Crettenden I, Townley M. Sleep disturbance in pain clinic patients. Pain. 1985;23:27–33.

    Article  CAS  PubMed  Google Scholar 

  48. Tang NKY, Goodchild CE, Hester J, Salkovskis PM. Pain-related insomnia: A comparision study of sleep pattern, psychological characteristics and cognitive-behavioural processes. Clinical journal of pain. 2012;428–436.

    Google Scholar 

  49. Wittig R, Zorick F, Blumer D, et al. Disturbed sleep in patients complaining of chronic pain. J Nerv Ment Dis. 1982;170:429–31.

    Article  CAS  PubMed  Google Scholar 

  50. Hirsch M, Carlander B, Vergé M, et al. Objective and subjective sleep disturbances in patients with rheumatoid arthritis. A reappraisal. Arthritis Rheum. 1994;37:41–9.

    Article  CAS  PubMed  Google Scholar 

  51. Landis C, Lentz M, Rothermel J, et al. Decreased sleep spindles and spindle activity in midlife women with fibromyalgia and pain. Sleep. 2004;27:741–50.

    PubMed  Google Scholar 

  52. Rizzi M, Sarzi-Puttini P, Atzeni F, et al. Cyclic alternating pattern: a new marker of sleep alteration in patients with fibromyalgia? J Rheumatol. 2004;31:1193–9.

    PubMed  Google Scholar 

  53. Martinez-Lavin M, Hermosillo AG, Rosas M, et al. Circadian studies of autonomic nervous balance in patients with fibromyalgia: a heart rate variability analysis. Arthritis Rheum. 1998;41:1966–71.

    Article  CAS  PubMed  Google Scholar 

  54. Moldofsky H, Scarisbrick P, England R, et al. Musculoskeletal symptoms and non-REM sleep disturbance in patients with “fibrositis syndrome” and healthy subjects. Psychosom Med. 1975;37:341–51.

    Article  CAS  PubMed  Google Scholar 

  55. Moldofsky H, Lue F. The relationship of alpha and delta EEG frequencies to pain and mood in ‘fibrositis’ patients treated with chlorpromazine and L-tryptophan. Electroencephalogr Clin Neurophysiol. 1980;50:71–80.

    Article  CAS  PubMed  Google Scholar 

  56. Horne JA, Shackell BS. Alpha-like EEG activity in non-REM sleep and the fibromyalgia (fibrositis) syndrome. Electroencephalogr Clin Neurophysiol. 1991;79:271–6.

    Article  CAS  PubMed  Google Scholar 

  57. Pivik RT, Harman K. A reconceptualization of EEG alpha activity as an index of arousal during sleep: all alpha activity is not equal. J Sleep Res. 1995;4:131–7.

    Article  PubMed  Google Scholar 

  58. Rains J, Penzien D. Sleep and chronic pain: challenges to the alpha-EEG sleep pattern as a pain specific sleep anomaly. J Psychosom Res. 2003;54:77–83.

    Article  PubMed  Google Scholar 

  59. Schneider-Helmert D, Whitehouse I, Kumar A, et al. Insomnia and alpha sleep in chronic non-organic pain as compared to primary insomnia. Neuropsychobiology. 2001;43:54–8.

    Article  CAS  PubMed  Google Scholar 

  60. Dauvilliers Y, Touchon J. Sleep in fibromyalgia: review of clinical and polysomnographic data. Neurophysiol Clin. 2001;31:18–33.

    Article  CAS  PubMed  Google Scholar 

  61. Moldofsky H, Tullis C, Lue F. Sleep related myoclonus in rheumatic pain modulation disorder (fibrositis syndrome). J Rheumatol. 1986;13:614–7.

    CAS  PubMed  Google Scholar 

  62. Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12:61–5.

    Article  CAS  PubMed  Google Scholar 

  63. Sun ER, Chen CA, Ho G, et al. Iron and the restless legs syndrome. Sleep. 1998;21:371–7.

    CAS  PubMed  Google Scholar 

  64. Polydefkis M, Allen RP, Hauer P, et al. Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology. 2000;55:1115–21.

    Article  CAS  PubMed  Google Scholar 

  65. Sand T, Hagen K, Schrader H. Sleep apnea and chronic headache. Cephalalgia. 2003;23:90–5.

    Article  CAS  PubMed  Google Scholar 

  66. Loh N, Dinner D, Foldvary N, et al. Do patients with obstructive sleep apnea wake up with headaches? Arch Intern Med. 1999;159:1765–8.

    Article  CAS  PubMed  Google Scholar 

  67. Germanowicz D, Lumertz MS, Martinez D, et al. Sleep disordered breathing concomitant with fibromyalgia syndrome. J Bras Pneumol. 2006;32:333–8.

    PubMed  Google Scholar 

  68. Sepici V, Tosun A, Köktürk O. Obstructive sleep apnea syndrome as an uncommon cause of fibromyalgia: a case report. Rheumatol Int. 2007;28:69–71.

    Article  PubMed  Google Scholar 

  69. Drewes AM, Nielsen KD, Arendt-Nielsen L, et al. The effect of cutaneous and deep pain on the electroencephalogram during sleep – an experimental study. Sleep. 1997;20:632–40.

    CAS  PubMed  Google Scholar 

  70. Lavigne G, Zucconi M, Castronovo C, et al. Sleep arousal response to experimental thermal stimulation during sleep in human subjects free of pain and sleep problems. Pain. 2000;84:283–90.

    Article  CAS  PubMed  Google Scholar 

  71. Lavigne G, Brousseau M, Kato T, et al. Experimental pain perception remains equally active over all sleep stages. Pain. 2004;110:646–55.

    Article  PubMed  Google Scholar 

  72. Onen S, Alloui A, Gross A, et al. The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res. 2001;10:35–42.

    Article  CAS  PubMed  Google Scholar 

  73. Moldofsky H, Scarisbrick P. Induction of neurasthenic musculoskeletal pain syndrome by selective sleep stage deprivation. Psychosom Med. 1976;38:35–44.

    Article  CAS  PubMed  Google Scholar 

  74. Lentz MJ, Landis CA, Rothermel J, et al. Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women. J Rheumatol. 1999;26:1586–92.

    CAS  PubMed  Google Scholar 

  75. Roehrs T, Hyde M, Blaisdell B, et al. Sleep loss and REM sleep loss are hyperalgesic. Sleep. 2006;29:145–51.

    PubMed  Google Scholar 

  76. Smith MT, Edwards RR, McCann UD, et al. The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep. 2007;30:494–505.

    PubMed  Google Scholar 

  77. Wilson KG, Watson ST, Currie SR. Daily diary and ambulatory activity monitoring of sleep in patients with insomnia associated with chronic musculoskeletal pain. Pain. 1998;75:75–84.

    Article  CAS  PubMed  Google Scholar 

  78. Chapman JB, Lehman CL, Elliott J, et al. Sleep quality and the role of sleep medications for veterans with chronic pain. Pain Med. 2006;7:105–14.

    Article  PubMed  Google Scholar 

  79. Affleck G, Urrows S, Tennen H, et al. Sequential daily relations of sleep, pain intensity, and attention to pain among women with fibromyalgia. Pain. 1996;68:363–8.

    Article  CAS  PubMed  Google Scholar 

  80. Nicassio PM, Moxham EG, Schuman CE, et al. The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain. 2002;100:271–9.

    Article  PubMed  Google Scholar 

  81. Theadom A, Cropley M. Dysfunctional beliefs, stress and sleep disturbance in fibromyalgia. Sleep Med. 2008;9:376–81.

    Article  PubMed  Google Scholar 

  82. Smith MT, Perlis ML, Carmody TP, et al. Presleep cognitions in patients with insomnia secondary to chronic pain. J Behav Med. 2001;24:93–114.

    Article  CAS  PubMed  Google Scholar 

  83. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Text Revision edition. 4th ed. Washington, DC: American Psychiatric Association; 2000.

    Book  Google Scholar 

  84. World Health Organization. International statistical classification of diseases and related health problems 10th revision. 2007. http://apps.who.int/classifications/apps/icd/icd10online/. Accessed 16 Sep 2009.

  85. American Academy of Sleep Medicine. International classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester: American Academy of Sleep Medicine; 2005.

    Google Scholar 

  86. Schramm E, Hohagen F, Grasshoff U, et al. Test-retest reliability and validity of the structured interview for sleep disorders according to DSM-III-R. Am J Psychiat. 1993;150:867–72.

    CAS  PubMed  Google Scholar 

  87. Edinger JD, Kirby AC, Lineberger MD, et al. DUKE structured interview schedule for DSM-IV-TR and international classification of sleep disorders, second edition (ICSD-2) sleep disorder diagnoses. Durham: Veterans Affairs and Duke University Medical Centers; 2006.

    Google Scholar 

  88. Bastien C, Vallières A, Morin CM. Validation of the insomnia severity index as a clinical outcome measure for insomnia research. Sleep Med. 2001;2:297–307.

    Article  PubMed  Google Scholar 

  89. Buysse DJ, Reynolds III CF, Monk TH, et al. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213.

    Article  CAS  PubMed  Google Scholar 

  90. Zomer J, Peled R, Rubin AHE, et al. Mini sleep questionnaire for screening large populations for excessive daytime sleepiness complaints. In: Koella W, Ruther E, Schulz U, editors. Sleep 1984. Stuttgart: Gustav Fisher Verlag; 1985. p. 467–70.

    Google Scholar 

  91. Hetta J, Almqvist M, Agren H, et al. Prevalence of sleep disturbances and related symptoms in a middle-aged Swedish population. In: Koella W, Ruther E, Schulz U, editors. Sleep 1984. Stuttgart: Gustav Fischer Verlag; 1985. p. 373–6.

    Google Scholar 

  92. Hays RD, Martin SA, Sesti AM, et al. Psychometric properties of the medical outcomes study sleep measure. Sleep Med. 2005;6:41–4.

    Article  PubMed  Google Scholar 

  93. Morin CM. Insomnia: psychological assessment and management. New York: Guilford Press; 1993.

    Google Scholar 

  94. Morin CM. Dysfunctional beliefs and attitudes about sleep: preliminary scale development and description. Behav Ther. 1994;17:163–4.

    Google Scholar 

  95. Espie CA. The psychological treatment of insomnia. Chichester: Wiley; 1991.

    Google Scholar 

  96. Tyron W. Issues of validity in actigraphic sleep assessment. Sleep. 2004;27:158–65.

    Google Scholar 

  97. Lavie P, Epstein R, Tzischinsky O, et al. Actigraphic measurements of sleep in rheumatoid arthritis: comparison of patients with low back pain and healthy controls. J Rheumatol. 1992;19:362–5.

    CAS  PubMed  Google Scholar 

  98. Landis CA, Frey CA, Lentz MJ, et al. Self-reported sleep quality and fatigue correlates with actigraphy in midlife women with fibromyalgia. Nurs Res. 2003;52:140–7.

    Article  PubMed  Google Scholar 

  99. Kushida CA, Chang A, Gadkary C, et al. Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Med. 2001;2:389–96.

    Article  CAS  PubMed  Google Scholar 

  100. Lichstein KL, Riedel BW. Behavioral assessment and treatment of insomnia: a review with an emphasis on clinical application. Behav Ther. 1994;25:659–88.

    Article  Google Scholar 

  101. Walker J, Farney R, Rhondeau S, et al. Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. J Clin Sleep Med. 2007;3:455–61.

    PubMed Central  PubMed  Google Scholar 

  102. Ballantyne JC, Mao J. Opioid therapy for chronic pain. N Engl J Med. 2003;349:1943–53.

    Article  CAS  PubMed  Google Scholar 

  103. Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol. 2007;20:456–72.

    Article  PubMed  Google Scholar 

  104. Legros B, Bazil C. Effects of antiepileptic drugs on sleep architecture: a pilot study. Sleep Med. 2003;4:51–5.

    Article  PubMed  Google Scholar 

  105. Garcia-Borreguero D, Larrosa O, de la Llave Y, et al. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology. 2002;59:1573–9.

    Article  CAS  PubMed  Google Scholar 

  106. Drug Enforcement Administration DoJ. Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Fed Regist. 2005;70:43633–5.

    Google Scholar 

  107. Tiihonen J, Lonnqvist J, Wahlbeck K, et al. Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Arch Gen Psychiatry. 2006;63:1358–67.

    Article  CAS  PubMed  Google Scholar 

  108. Perroud N, Uher R, Marusic A, et al. Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial. BMC Med. 2009;7:60.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  109. Berger A, Dukes EM, Edelsberg J, et al. Use of tricyclic antidepressants in older patients with painful neuropathies. Eur J Clin Pharmacol. 2006;62:757–64.

    Article  CAS  PubMed  Google Scholar 

  110. Bymaster F, Dreshfield-Ahmad L, Threlkeld P, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001;25:871–80.

    Article  CAS  PubMed  Google Scholar 

  111. Fava M, Mulroy R, Alpert J, et al. Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine. Am J Psychiatry. 1997;154:1760–2.

    CAS  PubMed  Google Scholar 

  112. Thase M. Effects of venlafaxine on blood pressure: a meta-analysis of original data from 3744 depressed patients. J Clin Psychiatry. 1998;59:502–8.

    Article  CAS  PubMed  Google Scholar 

  113. Krystal AD. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice. Sleep Med Rev. 2009;13:265–74.

    Article  PubMed  Google Scholar 

  114. Smith MT, Haythornthwaite JA. Cognitive-behavioral treatment for insomnia and pain. In: Lavigne G, Sessle B, Choiniere M, Soja P, editors. Sleep and pain. Seattle: ISAP; 2007. p. 439–57.

    Google Scholar 

  115. British Pain Society. Recommended guidelines for pain management programmes for adults. London: British Pain Society; 2007.

    Google Scholar 

  116. Ashworth PCH, Burke BL, McCracken L. Does a pain management programme help you sleep better? Clin Psychol Forum. 2008;184:35–40.

    Google Scholar 

  117. Morley S, Williams A, Hussain S. Estimating the clinical effectiveness of cognitive behavioural therapy in the clinic: evaluation of a CBT informed pain management programme. Pain. 2008;137:670–80.

    Article  PubMed  Google Scholar 

  118. Lichstein KL, Wilson NM, Johnson CT. Psychological treatment of secondary insomnia. Psychol Aging. 2000;15:232–40.

    Article  CAS  PubMed  Google Scholar 

  119. Currie SR, Wilson KG, Pontefract AJ, et al. Cognitive-behavioral treatment of insomnia secondary to chronic pain. J Consult Clin Psychol. 2000;68:407–16.

    Article  CAS  PubMed  Google Scholar 

  120. Edinger JD, Wohlgemuth WK, Krystal AD, et al. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med. 2005;165:2527–35.

    Article  PubMed  Google Scholar 

  121. Jungquist CR, O’Brien C, Matteson-Rusby S, et al. The efficacy of cognitive behavioral therapy for insomnia in patients with chronic pain. Sleep Med. 2010;11:302–9.

    Article  PubMed Central  PubMed  Google Scholar 

  122. Nikolaus T, Zeyfang A. Pharmacological treatments for persistent non-malignant pain in older persons. Drugs Aging. 2004;21:19–41.

    Article  CAS  PubMed  Google Scholar 

  123. Menefee LA, Cohen MJ, Anderson WR, et al. Sleep disturbance and nonmalignant chronic pain: a comprehensive review of the literature. Pain Med. 2000;1:156–72.

    Article  CAS  PubMed  Google Scholar 

  124. Shaw I, Lavigne G, Mayer P, et al. Acute intravenous administration of morphine perturbs sleep architecture in healthy pain-free young adults: a preliminary study. Sleep. 2005;28:677–82.

    PubMed  Google Scholar 

  125. Dimsdale J, Norman D, Dejardin D, et al. The effect of opioids on sleep architecture. J Clin Sleep Med. 2007;3:33–6.

    PubMed  Google Scholar 

  126. Rosenthal M, Moore P, Groves E, et al. Sleep improves when patients with chronic OA pain are managed with morning dosing of once a day extended-release morphine sulfate (AVINZA): findings from a pilot study. J Opioid Manag. 2007;3:145–54.

    PubMed  Google Scholar 

  127. Foldvary-Schaefer N, De Leon Sanchez I, Karafa M, et al. Gabapentin increases slow-wave sleep in normal adults. Epilepsia. 2002;43:1493–7.

    Article  CAS  PubMed  Google Scholar 

  128. Hindmarch I, Dawson J, Stanley N. A double-blind study in healthy volunteers to assess the effects on sleep of pregabalin compared with alprazolam and placebo. Sleep. 2005;28:187–93.

    PubMed  Google Scholar 

  129. Webster L, Choi Y, Desai H, et al. Sleep-disordered breathing and chronic opioid therapy. Pain Med. 2008;9:425–32.

    Article  PubMed  Google Scholar 

  130. Wang D, Teichtahl H, Drummer O, et al. Central sleep apnea in stable methadone maintenance treatment patients. Chest. 2005;128:1348–56.

    Article  PubMed  Google Scholar 

  131. Saarto T, Wiffen P. Antidepressants for neuropathic pain. Cochrane Database Syst Rev. 2007;CD005454.

    Google Scholar 

  132. Haddad PM, Dursun SM. Neurological complications of psychiatric drugs: clinical features and management. Hum Psychopharmacol. 2008;23 Suppl 1:15–26.

    Article  PubMed  Google Scholar 

  133. Chang C, Wu E, Chang I, et al. Benzodiazepine and risk of hip fractures in older people: a nested case-control study in Taiwan. Am J Geriatr Psychiatry. 2008;16:686–92.

    Article  PubMed  Google Scholar 

  134. Bartlett G, Abrahamowicz M, Grad R, et al. Association between risk factors for injurious falls and new benzodiazepine prescribing in elderly persons. BMC Fam Pract. 2009;10:1.

    Article  PubMed Central  PubMed  Google Scholar 

  135. Roehrs T, Roth T. Sleep and pain: interaction of two vital functions. Semin Neurol. 2005;25:106–16.

    Article  PubMed  Google Scholar 

  136. Morley S, Eccleston C, Williams A. Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache. Pain. 1999;80:1–13.

    Article  CAS  PubMed  Google Scholar 

  137. Redondo JR, Justo CM, Moraleda FV, et al. Long-term efficacy of therapy in patients with fibromyalgia: a physical exercise-based program and a cognitive-behavioral approach. Arthritis Rheum. 2004;51:184–92.

    Article  PubMed  Google Scholar 

  138. Gustavsson C, von Koch L. Applied relaxation in the treatment of long-lasting neck pain: a randomized controlled pilot study. J Rehabil Med. 2006;38:100–7.

    Article  PubMed  Google Scholar 

  139. Becker N, Sjogren P, Bech P, et al. Treatment outcome of chronic non-malignant pain patients managed in a Danish multidisciplinary pain centre compared to general practice: a randomised controlled trial. Pain. 2000;84:203–11.

    Article  CAS  PubMed  Google Scholar 

  140. Kerns RD, Turk DC, Rudy TE. The West Haven-Yale multidimensional pain inventory (WHYMPI). Pain. 1985;23:345–56.

    Article  CAS  PubMed  Google Scholar 

  141. Beck AT, Ward CH, Mendelson MM, et al. An inventory for measuring depression. Arch Gen Psych. 1961;4:561–71.

    Article  CAS  Google Scholar 

  142. Spielman AJ, Saskin P, Thorpy MJ. Treatment of chronic insomnia by restriction of time in bed. Sleep. 1987;10:45–55.

    CAS  PubMed  Google Scholar 

  143. Melzack R. The short-form McGill pain questionnaire. Pain. 1987;30:191–7.

    Article  CAS  PubMed  Google Scholar 

  144. Cleeland CS. Measurement of pain by subjective report. In: Chapman CR, Loeser JD, editors. Advances in pain research and therapy, volume 12: issues in pain measurement. New York: Raven; 1989. p. 391–403.

    Google Scholar 

  145. McNair DM, Lorr M, Droppleman LF. EDITS manual for the profile of mood states. San Diego: EDITS; 1971.

    Google Scholar 

  146. Ware JE, Snow KK, Kosinski M, et al. SF-36 health survey: manual and interpretation guide. Boston: The Health Institute, New England Medical Center; 1993.

    Google Scholar 

  147. Tait RC, Pollard CA, Margolis RB, et al. The pain disability index: psychometric and validity data. Arch Phys Med Rehabil. 1987;68:438–41.

    CAS  PubMed  Google Scholar 

  148. Vitello MV, Rybarczyk B, Von Korff M, et al. Cognitive behavioral therapy for insomnia improves sleep and decreases pain in older adults with co-morbid insomnia and osteoarthritis. J Clin Sleep Med. 2009;5:355–62.

    Google Scholar 

  149. Rybarczyk B, Stepanski E, Fogg L, et al. A placebo-controlled test of CBT for co-morbid insomnia in older adults. J Consult Clin Psychol. 2005;73:1164–74.

    Article  PubMed  Google Scholar 

  150. Haynes PL. Is CBT-I effective for pain? J Clin Sleep Med. 2009;5:363–4.

    PubMed Central  PubMed  Google Scholar 

  151. Tang NKY, Goodchild CE, Sanborn AN, Howard J, Salkovskis PM. Deciphering the temporal link between sleep and pain in a heterogeneous chronic pain patient sample: A multilevel daily process study. Sleep. 2012;5(35):675–68.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nicole K. Y. Tang D. Phil. (Oxon) .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 American Academy of Pain Medicine

About this chapter

Cite this chapter

Tang, N.K.Y., Goodchild, C.E., Webster, L.R. (2015). Sleep and Chronic Pain. In: Deer, T., Leong, M., Ray, A. (eds) Treatment of Chronic Pain by Integrative Approaches. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1821-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-1821-8_16

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1820-1

  • Online ISBN: 978-1-4939-1821-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics