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Vulvar Pathology pp 411–438Cite as

Vascular Lesions of the Vulva

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Abstract

The vulva is a rich vascularized organ of the lower genital tract; however, vascular lesions constitute a rare event. Most of these processes are asymptomatic and found incidentally requiring sometimes extensive surgical intervention. Diagnoses of vulvar vascular lesions as well as their extragenital counterpart can be challenging. Knowledge of the wide variety of presentations would ensure an early diagnosis and avoidance of potential aggressive treatment.

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References

  1. Papalas JA, Sangueza OP, Puri PK, Robboy SJ, Selim MA. Vulvar vascular tumors: a clinicopathologic study of 85 patients. Am J Dermatopathol. 2013;35(1):1–7.

    Article  PubMed  Google Scholar 

  2. Young AW, Wind RM, Tovell HMM. Lymphangioma of vulva. Acquired following treatment for cervical cancer. N Y State J Med. 1980;80(6):987–9.

    PubMed  Google Scholar 

  3. Stewart CJR, Chan T, Platten M. Acquired lymphangiectasia (‘lymphangioma circumscriptum’) of the vulva: a report of 8 cases. Pathology. 2009;41(5):448–53.

    Article  CAS  PubMed  Google Scholar 

  4. Haneef NS, Ramachandra S, Metta AK, Haritha K. Lymphangiectasias of vulva. Indian Dermatol Online J. 2011;2(1):40–2. doi:10.4103/2229-5178.79854.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Horn LC, Kuhndel K, Pawlowitsch T, Leo C, Einenkel J. Acquired lymphangioma circumscriptum of the vulva mimicking genital warts. Eur J Obstet Gynecol Reprod Biol. 2005;123(1):118–20.

    Article  PubMed  Google Scholar 

  6. Verma S. Pregnancy-induced lymphangiectasias of the vulva. Int J STD AIDS. 2008;19(3):211–2.

    Article  PubMed  Google Scholar 

  7. Mendiratta V, Harjai B, Sardana K. Tubercular lymphadenitis with lymphangiectases of the vulva. J Eur Acad Dermatol Venereol. 2005;19(2):264–5.

    Article  CAS  PubMed  Google Scholar 

  8. Bhat RM, Saldanha CS, Kambil SM, Dandakeri S. Cutaneous lymphangiectasia of the vulva secondary to tuberculosis. Indian J Sex Transm Dis. 2012;33(1):35–7.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Kennedy CTC. Lymphangiectasia of the vulva following hysterectomy and radiotherapy. Br J Dermatol. 1990;123 Suppl 37:92–3.

    Article  Google Scholar 

  10. Buckley DA, Barnes L. Vulvar lymphangiectasia due to recurrent cellulitis. Clin Exp Dermatol. 1996;21(3):215–6.

    Article  CAS  PubMed  Google Scholar 

  11. Papalas JA, Robboy SJ, Burchette JL, Foo WC, Selim MA. Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn’s associated lesions on radiation therapy induced tumors. J Cutan Pathol. 2010;37(9):958–65.

    Article  PubMed  Google Scholar 

  12. Sharma R, Tomar S, Chandra M. Acquired vulval lymphangiectases mimicking genital warts. Indian J Dermatol Venereol Leprol. 2002;68(3):166–7.

    PubMed  Google Scholar 

  13. Hamida MD, Baccouche D, El Fekih N, Fazaa B, Kamoun R. Lymphangiectasia of the vulva, treatment with CO2 laser. Indian J Dermatol Venereol Leprol. 2012;78(1):122.

    Google Scholar 

  14. Landthaler M, Hohenleutner U, Braun-Falco O. Acquired lymphangioma of the vulva: palliative treatment by means of laser vaporization carbon dioxide. Arch Dermatol. 1990;126(7):967–8.

    Article  CAS  PubMed  Google Scholar 

  15. Fadare O, Brannan SM, Arin-Silasi D, Parkash V. Localized lymphedema of the vulva: a clinicopathologic study of 2 cases and a review of the literature. Int J Gynecol Pathol. 2011;30(3):306–13.

    Article  PubMed  Google Scholar 

  16. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005;46(4):396–402.

    Article  CAS  PubMed  Google Scholar 

  17. Castro EC, Galambos C. Prox-1 and VEGFR3 antibodies are superior to D2-40 in identifying endothelial cells of lymphatic malformations – a proposal of a new immunohistochemical panel to differentiate lymphatic from other vascular malformations. Pediatr Dev Pathol. 2009;12(3):187–94.

    Article  PubMed  Google Scholar 

  18. Kontogianni-Katsaros K, Kairi-Vassilatoy E, Grapsa D, Papadias K, Hasiakos D, Kondi-Pafitis A. Angiokeratoma of the vulva: a rare benign tumor mimicking malignancy – case reports. Eur J Gynaecol Oncol. 2006;27(6):632–3.

    CAS  PubMed  Google Scholar 

  19. Cohen PR, Young Jr AW, Tovell HM. Angiokeratoma of the vulva: diagnosis and review of the literature. Obstet Gynecol Surv. 1989;44(5):339–46.

    Article  CAS  PubMed  Google Scholar 

  20. Fogagnolo L, Cintra ML, Velho PE. Angiokeratoma of the vulva. An Bras Dermatol. 2011;86(2):333–5.

    Article  PubMed  Google Scholar 

  21. Terzakis E, Androutsopoulos G, Zygouris D, Grigoriadis C, Derdelis G, Arnogiannaki N. Angiokeratoma of the vulva. Eur J Gynaecol Oncol. 2011;32(5):597–8.

    CAS  PubMed  Google Scholar 

  22. Yigiter M, Arda IS, Tosun E, Celik M, Hicsonmez A. Angiokeratoma of clitoris: a rare lesion in an adolescent girl. Urology. 2008;71(4):604–6.

    Article  PubMed  Google Scholar 

  23. Buljan M, Poduje S, Situm M, Bulat V, Bolanca Z, Tomas D. Multiple angiokeratomas of the vulva: case report and literature review. Acta Dermatovenerol Croat. 2010;18(4):271–5.

    PubMed  Google Scholar 

  24. McNeely TB. Angiokeratomas of the clitoris. Arch Pathol Lab Med. 1992;116(8):880–1.

    CAS  PubMed  Google Scholar 

  25. Ulker V, Cakir E, Gedikbasi A, Akyol A, Numanoglu C, Gulkilik A. Angiokeratoma of the clitoris with evident vulvar varicosity. J Obstet Gynaecol Res. 2010;36(6):1249–51.

    Article  PubMed  Google Scholar 

  26. Nakamura T, Kaneko H, Nishino I. Angiokeratoma corporis diffusum (Fabry disease): ultrastructural studies of the skin. Act Derm Venereol. 1981;61(1):37–41.

    CAS  Google Scholar 

  27. Requena L, Sangueza OP. Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997;37(6):887–919.

    Article  CAS  PubMed  Google Scholar 

  28. Gupta S, Radotra BD, Kumar B. Multiple, genital lobular capillary haemangioma (pyogenic granuloma) in a young woman: a diagnostic puzzle. Sex Transm Infect. 2000;76(1):51–2.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Arikan DC, Kiran G, Savar H, Kostu B, Coskun A, Kiran H. Vulvar pyogenic granuloma in a postmenopausal woman: case report and review of the literature. Case Rep Med. 2011;2011:201901.

    PubMed Central  PubMed  Google Scholar 

  30. Kaur T, Gupta S, Kumar B. Multiple pyogenic granuloma involving female genitalia: a rare entity? Pediatr Dermatol. 2004;21(5):614–5.

    Article  PubMed  Google Scholar 

  31. Patrice SJ, Wiss K, Mulliken JB. Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol. 1991;8(4):267–76.

    Article  CAS  PubMed  Google Scholar 

  32. LeBoit PE. Lobular capillary proliferation: the underlying process in diverse benign cutaneous vascular neoplasms and reactive conditions. Semin Dermatol. 1989;8(4):298–310.

    CAS  PubMed  Google Scholar 

  33. Nichols GE, Gaffey MJ, Mills SE, Weiss LM. Lobular capillary hemangioma: an immunohistochemical study including steroid hormone receptor status. Am J Clin Pathol. 1992;97(6):770–5.

    CAS  PubMed  Google Scholar 

  34. Kim TH, Lee HH, Koh ES. Intravascular papillary endothelial hyperplasia (Masson’s tumour) in the vulva. Eur J Obstet Gynecol Reprod Biol. 2013;169(2):413–4.

    Article  PubMed  Google Scholar 

  35. Maghari A, Lambert WC, Sherman N, Heller DS. Intravascular papillary endothelial hyperplasia (Masson tumor) manifesting as a cystic vulvar lesion. J Low Genit Tract Dis. 2009;13:260–3.

    Article  Google Scholar 

  36. Amerigo J, Berry CL. Intravascular papillary endothelial hyperplasia in the skin and subcutaneous tissue. Virchows Arch A Pathol Anat Histol. 1980;387(1):81–90.

    Article  CAS  PubMed  Google Scholar 

  37. Bruni V, Pontella V, Dei M, Alessandrini M, Li Marzi V, Nicita G. Hemangioma of the clitoris presenting as clitoromegaly: a case report. J Pediatr Adolesc Gynecol. 2009;22(5):e137–8.

    Article  PubMed  Google Scholar 

  38. Kondi-Pafiti A, Kairi-Vassilatou E, Spanidou-Carvouni H, Kontogianni K, Dimopoulou K, Goula K. Vascular tumors of the female genital tract: a clinicopathological study of nine cases. Eur J Gynaecol Oncol. 2003;24(1):48–50.

    CAS  PubMed  Google Scholar 

  39. Djunic I, Elezovic I, Ljubic A, Markovic O, Tomin D, Tadic J. Diffuse cavernous hemangioma of the left leg, vulva, uterus, and placenta of a pregnant woman. Int J Gynaecol Obstet. 2009;107(3):250–1.

    Article  PubMed  Google Scholar 

  40. Cebesoy FB, Kutlar I, Aydin A. A rare mass formation of the vulva: giant cavernous hemangioma. J Low Genit Tract Dis. 2008;12(1):35–7.

    Article  PubMed  Google Scholar 

  41. Mouhari-Toure A, Azoumah KD, Tchamdja K, Saka B, Kombate K, Tchangai-Walla K, Pitche P. Rapid regression of infantile haemangioma with 2 % propranolol treatment. Ann Dermatol Venereol. 2013;140(6–7):462–4.

    Article  CAS  PubMed  Google Scholar 

  42. Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ, Friedlander SF, Boon L, et al. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7–9, 2005, Bethesda, Maryland. Pediatr Dermatol. 2005;22(5):383–406.

    Article  PubMed  Google Scholar 

  43. Hermans DJ, Bauland CG, Zweegers J, van Beynum IM, van der Vleuten CJ. Propanolol in a case series of 174 patients with complicated infantile haemangioma: indications, safety and future directions. Br J Dermatol. 2013;168(4):837–43.

    Article  CAS  PubMed  Google Scholar 

  44. Menezes MD, McCarter R, Greene EA, Bauman NM. Status of propranolol for treatment of infantile hemangioma and description of a randomized clinical trial. Ann Otol Rhinol Laryngol. 2011;120(10):686–95.

    PubMed  Google Scholar 

  45. North PE, Waner M, Mizeracki A, Mihm Jr MC. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 2000;31(1):11–22.

    Article  CAS  PubMed  Google Scholar 

  46. North PE, Waner M, Mizeracki A, Mark RE, Micholas R, Kincannon J, et al. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol. 2001;137(5):559–70.

    CAS  PubMed  Google Scholar 

  47. Boon LM, Enjolras O, Mulliken JB. Congenital hemangiomas: evidence for accelerated involution. J Pediatr. 1996;128(3):329–35.

    Article  CAS  PubMed  Google Scholar 

  48. Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, et al. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6(6):495–510.

    Article  PubMed  Google Scholar 

  49. Enjolras O, Mulliken JB, Boon LM, Wassef M, Kozakewich HP, Burrows PE. Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plast Reconstr Surg. 2001;107(7):1647–54.

    Article  CAS  PubMed  Google Scholar 

  50. Goh SG, Calonje E. Cutaneous vascular tumours: an update. Histopathology. 2008;52(6):661–73.

    Article  CAS  PubMed  Google Scholar 

  51. Vlastos AT, Malpica A, Follen M. Lymphangioma circumscriptum of the vulva: a review of the literature. Obstet Gynecol. 2003;101(5 Pt 1):946–54.

    Article  PubMed  Google Scholar 

  52. Roy KK, Agarwal R, Agarwal S, Kumar S, Malhotra N, Gopendru N. Recurrent vulval congenital lymphangioma circumscriptum – a case report and literature review. Int J Gynecol Cancer. 2006;16(2):930–4.

    Article  CAS  PubMed  Google Scholar 

  53. Yildiz F, Atahan IL, Ozyar E, Karcaltincaba M, Cengiz M, Ozyigit G, et al. Radiotherapy in congenital vulvar lymphangioma circumscriptum. Int J Gynecol Cancer. 2008;18(3):556–9.

    Article  CAS  PubMed  Google Scholar 

  54. Aggarwal K, Gupta S, Jain VK, Marwah N. Congenital lymphangioma circumscriptum of the vulva. Indian Pediatr. 2009;46(5):428–9.

    PubMed  Google Scholar 

  55. Ozeki M, Fukao T, Kondo N. Propranolol for intractable diffuse lymphangiomatosis. N Engl J Med. 2011;364(14):1380–2.

    Article  CAS  PubMed  Google Scholar 

  56. Darmstadt GL. Perianal lymphangioma circumscriptum mistaken for genital warts. Pediatrics. 1996;98(3 Pt 1):461–3.

    CAS  PubMed  Google Scholar 

  57. Sonobe H, Ro JY, Ramos M, Diaz I, Mackay B, Ordonez NG, Ayala AG. Glomus tumor of the female external genitalia: a report of two cases. Int J Gynecol Pathol. 1994;13(4):359–64.

    Article  CAS  PubMed  Google Scholar 

  58. Katz VL, Askin FB, Bosch BD. Glomus tumor of the vulva: a case report. Obstet Gynecol. 1986;67(3 Suppl):43S–5S.

    Article  CAS  PubMed  Google Scholar 

  59. Jagadha V, Srinivasan K, Panchacharam P. Glomus tumor of the clitoris. N Y State J Med. 1985;85(10):611.

    CAS  PubMed  Google Scholar 

  60. Kohorn EI, Merino MJ, Goldenhersh M. Vulvar pain and dyspareunia due to glomus tumor. Obstet Gynecol. 1986;67(3 Suppl):41S–2S.

    Article  CAS  PubMed  Google Scholar 

  61. Dervan PA, Tobbia IN, Casey M, O’Loughlin J, O’Brien M. Glomus tumours: an immunohistochemical profile of 11 cases. Histopathology. 1989;14(5):483–91.

    Article  CAS  PubMed  Google Scholar 

  62. Brooks JJ, Miettinen M, Virtanen I. Desmin immunoreactivity in glomus tumors. Am J Clin Pathol. 1987;87(2):292.

    CAS  PubMed  Google Scholar 

  63. Hall DJ, Burns JC, Goplerud DR. Kaposi’s sarcoma of the vulva: a case report and brief review. Obstet Gynecol. 1979;54(4):478–83.

    CAS  PubMed  Google Scholar 

  64. Laartz BW, Cooper C, Degryse A, Sinnott JT. Wolf in sheep’s clothing: advanced Kaposi sarcoma mimicking vulvar abscess. South Med J. 2005;98(4):475–7.

    Article  PubMed  Google Scholar 

  65. Da Silva BB, Lopes-Costa PV, Furtado-Veloso AM, Borges RS. Vulvar epithelioid hemangioendothelioma. Gynecol Oncol. 2007;105(2):539–41.

    Article  PubMed  Google Scholar 

  66. Strayer SA, Yum MN, Sutton GP. Epithelioid hemangioendothelioma of the clitoris: a case report with immunohistochemical and ultrastructural findings. Int J Gynecol Pathol. 1992;11(3):234–9.

    Article  CAS  PubMed  Google Scholar 

  67. Guirquis A, Kanbour-Shakir A, Kelley J. Epithelioid angiosarcoma of the mons after chemoradiation for vulvar cancer. Int J Gynecol Pathol. 2007;26(3):265–8.

    Article  Google Scholar 

  68. Sanz C, Moreno F, Armas A, Casado A, Castillo MC. Groin angiosarcoma following radiotherapy for vulvar cancer. Gynecol Oncol. 2005;97(2):677–80.

    Article  PubMed  Google Scholar 

  69. Huey GR, Stehman FB, Roth LM, Ehrlich CE. Lymphangiosarcoma of the edematous thigh after radiation therapy for carcinoma of the vulva. Gynecol Oncol. 1985;20(3):394–401.

    Article  CAS  PubMed  Google Scholar 

  70. Leborgne F, Falconi LM. Lymphangiosarcoma of the anterior abdominal wall: a case report. Cancer. 1980;46(5):1228–30.

    Article  CAS  PubMed  Google Scholar 

  71. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266(5192):1865–9.

    Article  CAS  PubMed  Google Scholar 

  72. Mohammed AZ, Nwana EJ, Manasseh AN. Changing patterns of Kaposi’s sarcoma in Nigerians. Trop Doct. 2005;35(3):168–9.

    Article  CAS  PubMed  Google Scholar 

  73. Russell Jones R, Orchard G, Zelger B, Wilson JE. Immunostaining for CD31 and CD34 in Kaposi sarcoma. J Clin Pathol. 1995;48(11):1011–16.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  74. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi’s sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15(4):434–40.

    Article  PubMed  Google Scholar 

  75. Reis RM, Reis-Filho JS, Longatto Filho A, Tomarev S, Silva P, Lopes JM. Differential Prox-1 and CD31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. Pathol Res Pract. 2005;201(12):771–6.

    Article  CAS  PubMed  Google Scholar 

  76. Cheuk W, Wong KO, Wong CS, Dinkel JE, Ben-Dor D, Chan JK. Immunostaining for human herpesvirus 8 latent nuclear antigen-1 helps distinguish Kaposi sarcoma from its mimickers. Am J Clin Pathol. 2004;121(3):335–42.

    Article  PubMed  Google Scholar 

  77. Pantanowitz L, Pinkus GS, Dezube BJ, Tahan SR. HHV8 is not limited to Kaposi’s sarcoma. Mod Pathol. 2005;18(8):1148–50.

    Article  PubMed  Google Scholar 

  78. Long SR, Whitfeld MJ, Eades C, Koehler JE, Korn AP, Zaloudek CJ. Bacillary angiomatosis of the cervix and vulva in a patient with AIDS. Obstet Gynecol. 1996;88(4 Pt 2):709–11.

    Article  CAS  PubMed  Google Scholar 

  79. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50(5):970–81.

    Article  CAS  PubMed  Google Scholar 

  80. Deyrup AT, Tighiouart M, Montag AG, Weiss SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008;32(6):924–7.

    Article  PubMed  Google Scholar 

  81. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK. Cytokeratin expression in epithelioid vascular neoplasms. Hum Pathol. 1990;21(2):212–7.

    Article  CAS  PubMed  Google Scholar 

  82. Miettinen M, Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol. 2000;31(9):1062–7.

    Article  CAS  PubMed  Google Scholar 

  83. Mendlick MR, Nelson M, Pickering D, Johansson SL, Seemayer TA, Neff JR, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. Am J Surg Pathol. 2001;25(5):684–7.

    Article  CAS  PubMed  Google Scholar 

  84. Tanas MR, Sboner A, Oliveira AM, Erickson-Johnson MR, Hespelt J, Hanwright PJ, et al. Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Sci Transl Med. 2011;3(98):98ra82.

    Google Scholar 

  85. Errani C, Zhang L, Sung YS, Hajdu M, Singer S, Maki RG, et al. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer. 2011;50(8):644–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  86. Antonescu CR, Le Loarer F, Mosquera JM, Sboner A, Zhang L, Chen CL, et al. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer. 2013;52(8):775–84.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  87. Manner J, Radlwimmer B, Hohenberger P, Mossinger K, Kuffer S, Sauer C, et al. MYC high-level gene amplification in a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol. 2010;176(1):34–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  88. Mentzel T, Schildhaus HU, Palmedo G, Buttner R, Kutzner H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 2012;25(1):75–85.

    Article  CAS  PubMed  Google Scholar 

  89. Shon W, Sukov WR, Jenkins SM, Folpe AL. MYC amplification and overexpression in primary cutaneous angiosarcoma: a fluorescence in-situ hybridization and immunohistochemical study. Mod Pathol. 2014;27(4):509–15.

    Article  CAS  PubMed  Google Scholar 

  90. Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer. 2011;50(1):25–33.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  91. Santos LD, Krivanek MJ, Chan F, Killingsworth M. Pseudoangiosarcomatous squamous cell carcinoma of the vulva. Pathology. 2006;38(6):581–4.

    Article  PubMed  Google Scholar 

  92. Horn LC, Liebert UG, Edelmann J, Hockel M, Einenkel J. Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma – report of a case and review of the literature. Int J Gynecol Pathol. 2008;27(2):288–91.

    PubMed  Google Scholar 

  93. Bell D, Kane PB, Liang S, Conway C, Tornos C. Vulvar varices: an uncommon entity in surgical pathology. Int J Gynecol Pathol. 2007;26(1):99–101.

    Article  PubMed  Google Scholar 

  94. Cohen-Sacher B, Berger MB, Fenner DE, Burney RE, Haefner HK. Vulvar varicosities mimicking a hernia: case report. J Low Genit Tract Dis. 2012;16(4):464–7.

    Article  PubMed  Google Scholar 

  95. Vin F. Vulvar varices. J Mal Vasc. 1990;15(4):409–9.

    Google Scholar 

  96. Leung SW, Leung PL, Yuen PM, Rogers MS. Isolated vulvar varicosity in the non-pregnant state: a case report with review of treatment options. Aust N Z J Obstet Gynaecol. 2005;45(3):254–6.

    Article  PubMed  Google Scholar 

  97. Scultetus AH, Villavicencio JL, Gillespie DL, Kao TC, Rich NM. The pelvic venous syndromes: analysis of our experience with 57 patients. J Vasc Surg. 2002;36(5):881–8.

    Article  PubMed  Google Scholar 

  98. Ninia JG, Goldberg TL. Treatment of vulvar varicosities by injection-compression sclerotherapy and pelvic supporter. Obstet Gynecol. 1996;87(5 Pt 1):786–8.

    Article  CAS  PubMed  Google Scholar 

  99. Handfield-Jones SE, Prendiville WJ, Norman S. Vulval lymphangiectasia. Genitourin Med. 1989;65(5):335–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  100. Mu XC, Tran TA, Dupree M, Carlson JA. Acquired vulvar lymphangioma mimicking genital warts. A case report and review of the literature. J Cutan Pathol. 1999;26(3):150–4.

    Article  CAS  PubMed  Google Scholar 

  101. Pedica F, Ligorio C, Tonelli P, Bartolini S, Baccarini P. Lymphangiogenesis in Crohn’s disease: an immunohistochemical study using monoclonal antibody D2-40. Virchows Arch. 2008;452(1):57–63.

    Article  CAS  PubMed  Google Scholar 

  102. Heatley RV, Bolton PM, Hughes EL, Owen EW. Mesenteric lymphatic obstruction in Crohn’s disease. Digestion. 1980;20(5):307–13.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Mai P. Hoang M.D.

  2. Departments of Pathology and Dermatology, Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC, USA

    Omar P. Sangueza M.D.

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  1. Mai P. Hoang M.D.
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  2. Omar P. Sangueza M.D.
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Correspondence to Mai P. Hoang M.D. .

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Editors and Affiliations

  1. Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Mai P. Hoang

  2. Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA

    Maria Angelica Selim

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Hoang, M.P., Sangueza, O.P. (2015). Vascular Lesions of the Vulva. In: Hoang, M., Selim, M. (eds) Vulvar Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1807-2_14

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